Novel synthesis of aliphatic nitriles from amidines

Tetrahedron Letters

Volumn 39, Issue 21, 1998, Pages 3551-3554

  Caldarelli, Marina ^a   Biasoli, Giovanni ^a   Cozzi, Paolo ^a   Mongelli, Nicola ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAMIDINE DERIVATIVE; ACETIC ANHYDRIDE; ACID ANHYDRIDE; ALIPHATIC COMPOUND; AMIDINE; BENZAMIDINE DERIVATIVE; DISTAMYCIN A; GLUTARIC ACID DERIVATIVE; NITRILE; SUCCINIC ANHYDRIDE; TALLIMUSTINE;

ARTICLE; CHEMICAL MODIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SYNTHESIS;

EID: 0032554955     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)00546-2     Document Type: Article

References (10)

1. Boyd, G. V. The Chemistry of Amidines and Imidates Vol.2, Edited by S. Patai and Zvi Rappoport, John Wiley & Sons, N.Y., 1991, pp. 340-345.
2. Graefe, J. Z. Chem. 1975, 15, 301.
3. Barnikow, G.; Ebeling, H. Z. Chem. 1971, 11, 103.
4. Cozzi, P.; Beria, I.; Caldarelli, M.; Geroni, M. C.; Pesenti, E. Patent WO9728123.
5. Pezzoni, G.; Grandi, M.; Biasoli, G.; Capolongo, L.; Ballinari, D.; Giuliani, F. C.; Barbieri, B.; Pastori, A.; Pesenti, E.; Mongelli, N.; Spreafico, F. Br.J.Cancer, 1991, 64, 1047.
6. (a) Arcamone, F.; Orezzi, P. G.; Barbieri, W.; Nicolella, V.; Penco, S. Gazz.Chim.Ital. 1967, 97, 1097.
7. (b) Penco, S.; Redaelli, S. Arcamone, F. Gazz.Chim.Ital. 1967, 97, 1110.
8. The reaction was followed via GLC.
9. Cozzi, P.; Beria, I.; Biasoli, G.; Caldarelli, M.; Capolongo, L.; Geroni, M. C.; Mongelli, N. Bioorg.Med.Chem.Lett. 1997, 7, 2979.
10. Cossy, J.; Schmitt, A.; Cirquin, C.; Buisson, D.; Belotti, D. Bioorg.Med.Chem.Lett. 1997, 7, 1699.