Phthalimidomethyl as a drug pro-moiety. Probing its reactivity

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 8, 1998, Pages 955-958

  Iley, Jim ^a   Calheiros, Teresa ^b   Moreira, Rui ^b  

^a OPEN UNIVERSITY   (United Kingdom)

^b RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONYL DERIVATIVE; PHTHALIMIDE DERIVATIVE; PHTHALIMIDOMETHYL; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; HYDROLYSIS;

HYDROLYSIS; INDICATORS AND REAGENTS; KINETICS; MOLECULAR STRUCTURE; PHTHALIMIDES; PRODRUGS; SACCHARIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032554692     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00135-8     Document Type: Article

References (17)

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4. 4 (pH 5.90) eluant; retention times at a flow rate of 1ml/min: 6, 3.8 min; N-hydroxymethylphthalimide, 5.7 min; phthalimide, 7.5 min.
5. 2O), 7.65-7.97 (4H, m). Found (calc.) C, 48.5 (48.6); H, 2.71 (2.70); N, 12.4 (12.6)%.
6. 5. Esters 1c (Jansen, A.B.A.; Russel, T.J.; J.Chem.Soc., 1965, 2127) and 1d-g and 1i,j (Iley, J.; Moreira, R.; Rosa, E.; J.Chem.Soc Perkin 2; 1991, 563) gave satisfactory elemental analyses and spectral data
7. 5. Esters 1c (Jansen, A.B.A.; Russel, T.J.; J.Chem.Soc., 1965, 2127) and 1d-g and 1i,j (Iley, J.; Moreira, R.; Rosa, E.; J.Chem.Soc Perkin 2; 1991, 563) gave satisfactory elemental analyses and spectral data
8. 2O), 7.78-7.82 (4H, m). Found (calc.) C, 62.3 (62.8); H, 4.67 (4.71); N, 7.10 (7.33)%.
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12. -].
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