Studies on an immunosuppressive macrolactam, ascomycin: Synthesis of a C-33 hydroxyl derivative

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 8, 1998, Pages 935-938

  Kawai, Megumi ^a   Gunawardana, Indrani W K ^a   Mollison, Karl W ^a   Hsieh, Gin C ^a   Lane, Benjamin C ^a   Luly, Jay R ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCOMYCIN; TACROLIMUS;

ARTICLE; DRUG SOLUBILITY; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; MIXED LYMPHOCYTE REACTION; NUCLEAR MAGNETIC RESONANCE; X RAY CRYSTALLOGRAPHY;

EID: 0032554690     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00145-0     Document Type: Article

References (13)

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9. 9. Deprotection of C-24-TBDMS from 9 has led to a compound having a keto at C-31 position; C-31keto-C32-deoxy-ascomycin in good yield.
10. 3N. Despite our careful experimental procedure, a very small percentage of chloro substitution always occurred. However, no chloro substitutions were observed when DIPEA was used.
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