Insertion of two independent enhancers in the long terminal repeat of a self-inactivating vector results in high-titer retroviral vectors with tissue-specific expression

Human Gene Therapy

Volumn 9, Issue 17, 1998, Pages 2459-2468

  Fassati, Ariberto ^a,b,h   Bardoni, Alessandra ^a,c,d   Sironi, Manuela ^d   Wells, Dominic J ^e   Bresolin, Nereo ^d   Scarlato, Guglielmo ^d   Hatanaka, Masakazu ^f   Yamaoka, Shoji ^g   Dickson, George ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c SCIENTIFIC INSTITUTE   (Italy)

^d FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^e IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^f SHIONOGI AND CO LTD   (Japan)

^g KYOTO UNIVERSITY   (Japan)

^h Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE KINASE; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; CELL CLONE; CONTROLLED STUDY; ENHANCER REGION; EXPRESSION VECTOR; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS; LONG TERMINAL REPEAT; MOUSE; MURINE LEUKEMIA VIRUS; MUSCLE REGENERATION; MYOBLAST; MYOTUBE; NONHUMAN; PROMOTER REGION; RETROVIRUS; SKELETAL MUSCLE; TISSUE SPECIFICITY; TRANSACTIVATION;

3T3 CELLS; ANIMALS; BASE SEQUENCE; CELL LINE; DNA PRIMERS; ENHANCER ELEMENTS (GENETICS); GENE PRODUCTS, TAX; GENES, REPORTER; GENETIC COMPLEMENTATION TEST; GENETIC VECTORS; HUMAN T-LYMPHOTROPIC VIRUS 1; KANAMYCIN KINASE; LAC OPERON; LUCIFERASES; MICE; MICE, NUDE; PLASMIDS; REPETITIVE SEQUENCES, NUCLEIC ACID; RETROVIRIDAE;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN T-LYMPHOTROPIC VIRUS 1; MURINAE; MURINE LEUKEMIA VIRUS; UNIDENTIFIED RETROVIRUS;

EID: 0032553649     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430349850019300     Document Type: Article

References (41)

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