Glibenclamide, an antagonist of ATP sensitive K+ channels, blocks free radical generation in the rat myocardium

Neuroscience Letters

Volumn 257, Issue 1, 1998, Pages 57-59

  Obata, Toshio ^a   Yamanaka, Yasumitsu ^a  

^a OITA UNIVERSITY   (Japan)

Author keywords

Allopurinol; Depolarization; Glibenclamide; Hydroxyl free radical; Potassium chloride

Indexed keywords

ALLOPURINOL; FREE RADICAL; GLIBENCLAMIDE; HYDROXYL RADICAL; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; HEART DEPOLARIZATION; HEART MUSCLE CELL; INTRACARDIAC DRUG ADMINISTRATION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ALLOPURINOL; ANIMALS; ENZYME INHIBITORS; FREE RADICALS; GENTISATES; GLYBURIDE; HEART; HYDROXYBENZOIC ACIDS; MALE; MICRODIALYSIS; MYOCARDIUM; PERFUSION; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHLORIDE; RATS; RATS, WISTAR; SODIUM SALICYLATE; SUCROSE;

EID: 0032553349     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00768-X     Document Type: Article

References (17)

1. Bulktey G.B. Free radical-mediated reperfusion injury: a selective review. Br. J. Cancer Suppl. 8:1987;66-73.
2. + channels protect the myocardium against ischemia/reperfusion damage. Circ. Res. 69:1991;571-581.
3. Floyd R.A., Watson J.J., Wong P.K. Sensitive assay of hydroxyl free radical formation utilizing high pressure liquid chromatography with electrochemical detection of phenol and salicylate hydroxylation products. J. Biochem. Biophys. Methods. 10:1984;221-235.
4. Grootveld M., Halliwell B. Aromatic hydroxylation as a potential measure of hydroxyl radical formation in vivo. Biochem. J. 237:1986;499-504.
5. Halliwell B., Kaur H., Ingleman-Sundberg M. Hydroxylation of salicylate as an assay for hydroxyl radicals: a cautionary note. Free Rad. Biol. Med. 10:1991;439-441.
6. Hearse D.J. Activation of ATP-sensitive potassium channels: a novel pharmacological approach to myocardial protection? Cardiovasc. Res. 30:1995;1-17.
7. Hoffmann P., Richards D., Heinroth-Hoffmann I., Mathias P., Wey H., Toraason M. Arachidonic acid disrupts calcium dynamics in neonatal rat cardiac myocytes. Cardiovasc. Res. 30:1995;889-898.
8. Malik K.U., Sehic E. Prostaglandins and the release of the adrenergic transmitter. Ann. N Y Acad. Sci. 604:1990;222-236.
9. McCord J.M. Oxygen-derived free radicals in postischemic tissue injury. N. Engl. J. Med. 312:1985;159-163.
10. Obata, T., Hosokawa, H. and Yamanaka, Y., In vivo monitoring of norepinephrine and OH generation on myocardial ischemic injury by dialysis technique, Am. J. Physiol., 266 (Heart Circ. Physiol., 35) (1994) H903-H908.
11. Obata T., Yamanaka Y. Intracranial microdialysis of salicylic acid to detect hydroxyl radical generation by monoamine oxidase inhibitor in the rat. Neurosci. Lett. 188:1995;13-16.
12. Obata T., Yamanaka Y. Cardiac microdialysis of salicylic acid to detect hydroxyl radical associated with sympathetic nerve stimulation. Biochem. Pharmacol. 51:1997;1411-1413.
13. Obata T., Yamanaka Y. Evidence of hydroxyl free radical generation by calcium overload in rat myocardium. J. Pharm. Pharmacol. 49:1997;787-790.
14. 2+ signaling by inorganic mercury in PC12 cells. Fed. Am. Soc. Exp. Biol. J. 15:1993;1507-1514.
15. + channels in early phase of reperfusion and its protective role against myocardial stunning. Circulation. 92:1995;2266-2275.
16. ATP channel by oxygen free radicals produced by xanthine oxidase reaction. Am. J. Physiol. 271:1996;H478-H489.
17. Wheatley A.M., Thandroyen F.T., Opie L.H. Catecholamine-induced myocardial cell damage: catecholamines or adrenochrome. J. Mol. Cell Cardiol. 17:1985;349-359.