β-analogs of PLG (L-prolyl-L-leucyl-glycinamide): Ex-chiral pool syntheses and dopamine D2 receptor modulating effects

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 20, 1998, Pages 2885-2890

  Thomas, Christoph ^a   Ohnmacht, Ursula ^a   Niger, Martin ^b   Gmeiner, Peter ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE 2 RECEPTOR STIMULATING AGENT; PROLYLLEUCYLGLYCINAMIDE;

ARTICLE; CHIRALITY; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENANTIOMER; HUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZOTHIAZOLES; CATTLE; CELL MEMBRANE; DOPAMINE AGONISTS; MSH RELEASE-INHIBITING HORMONE; RECEPTORS, DOPAMINE D2; THIAZOLES; VISUAL CORTEX;

EID: 0032552918     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00507-1     Document Type: Article

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13. D=-4.8° (1.0, EtOH).
14. D=-0.7° (5.0, EtOH ).
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18. D=+10.4° (2.0, MeOH).
19. D=-3.0° (2.0, MeOH).
20. D=27.3 (1.35, MeOH).
21. 3).
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