Cytotoxic T-cell responses to HIV-1 reverse transcriptase, integrase and protease

AIDS

Volumn 12, Issue 12, 1998, Pages 1427-1436

  Haas, Gaby ^b   Samri, Assia ^a   Gomard, Elisabeth ^c   Hosmalin, Anne ^a   Duntze, Joerg ^a   Bouley, Jean Marc ^a   Ihlenfeldt, Hans Georg ^d   Katlama, Christine ^a   Autran, Brigitte ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

^c INSTITUT COCHIN   (France)

^d UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

AIDS; Cytotoxic T cells; HIV; Human T cells; Integrase; Protease; Reverse transcriptase

Indexed keywords

CD4 ANTIGEN; INTEGRASE; PROTEINASE; RNA DIRECTED DNA POLYMERASE;

ANTIGENICITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOGENICITY; MAJOR CLINICAL STUDY; MEMORY CELL; NONHUMAN; PRIORITY JOURNAL;

COHORT STUDIES; EPITOPES; GENE PRODUCTS, POL; HIV INTEGRASE; HIV PROTEASE; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; IMMUNODOMINANT EPITOPES; IMMUNOLOGIC MEMORY; PEPTIDES; T-LYMPHOCYTES, CYTOTOXIC; VACCINES, SYNTHETIC; VACCINIA VIRUS;

EID: 0032552120     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199812000-00004     Document Type: Article

References (40)

1. Koup RA, Safrit JT, Cao Y, et al.: Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J Virol 1994, 68:4650-4655.
2. Rinaldo C, Huang XL, Fan Z, et al.: High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term non progressors J Virol 1995, 69:5838-5842.
3. Rivière Y, McChesney MB, Porrot F, et al.: Gag-specific cytotoxic responses to HIV type 1 are associated with a decreased risk of progression to AIDS-related complex or AIDS. AIDS Res Hum Retrovirus 1995, 8:903-907.
4. Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P: Identification of RANTES, MIP-1a, and MIP-1β as the major HIV-suppressive factors produced by CD8+ T cells. Science 1995, 270:1811-1815.
5. Plata F, Autran B, Martins LP, et al.: AIDS-virus specific cytotoxic T-lymphocytes in lung disorders. Nature 1987, 328:348-352.
6. Koenig S, Earl SP, Pawell D, et al.: Group-specific, MHC class-1-restricted cytotoxic responses to HIV-1 envelope proteins by cloned peripheral blood T cells from an HIV-1 infected individual. Proc Natl Acad Sci USA 1988, 8:8638-8642.
7. Walker BD, Flexner C, Paradis TJ, et al: HIV-1 reverse transcriptase is a target for cytotoxic T lymphocytes in infected individuals. Science 1988, 240:64-66.
8. Lamhamedi-Cherradi S, Culmann-Penciolelli B, Guy B, et al.: Qualitative and quantitative analysis of human cytotoxic T lymphocyte responses to HIV. AIDS 1992, 6:1249-1258.
9. Hadida F, Haas G, Zimmermann N, et al.: Cytotoxic T lymphocytes from lymphoid organs recognize an optimal HLA-A2 and -B52 restricted nonapeptide and several epitopes in the C-terminal region of HIV-1 Nef. J Immunol 1995, 154:4174-4186.
10. Phillips RE, Rowland-Jones S, Nixon D, et al.: Human immunodeficiency virus variants that escape cytotoxic T-cell recognition. Nature 1991, 354:453-459.
11. Meyerhans A, Dadaglio G, Vartanian JP, et al.: In vivo persistence of A HIV-1-encoded HLA-B27-restricted cytotoxic T lymphocyte epitope despite specific in vitro reactivity. Eur J Immunol 1991, 21:2637-2640.
12. Haas G, Plikat U, Debré P, et al.: Dynamics of cytotoxic T lymphocytes specific for HIV-1 Nef and viral variation in vivo. J Immunol 1996, 157:4212-4221.
13. Lightfoote MM, Coligan JE, Folks TM, Fauci AS, Martin MA, Venkatesan S: Structural characterization of reverse transcriptase and endonuclease polypeptides of the acquired immunodeficiency syndrome retrovirus. J Virol 1986, 60:771-775.
14. Lamhamedi-Cherradi S, Culmann-Penciolelli B, Guy B, et al.: Different patterns of HIV-1-specific cytotoxic T lymphocyte activity after primary infection. AIDS 1995, 9:421-426.
15. Walker BD, Flexner C, Birch-Limberger K, et al.: Long term culture and fine specificity of human cytotoxic T cell clones reactive with human immunodeficiency virus type 1. Proc Natl Acad Sci USA 1989, 86:9514-9517.
16. Van der Burg S, Klein M, Pontesilli O, et al.: HIV-1 reverse transcriptase-specific CTL against conserved epitopes do not protect against progression to AIDS. J Immunol 1997, 159:3648-3654.
17. Jung M, Agul H, Candotti D, Ingrand D, Katlama C, Huraux JM: Susceptibility of HIV-1 isolates to zidovudine: correlation between widely applicable culture test and PCR analysis. J Acquir Immune Defic Syndr 1992, 5:359-364.
18. Larder BA: Interactions between drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase. J Gen Virol 1994, 75:951-957.
19. Myers G, Korber B, Hahn B, et al.: Human Retroviruses and AIDS. Los Alamos: Los Alamos National Laboratory, 1995.
20. Rammensee HG, Friede T, Stevanovic S: MHC ligands and peptide motifs: first listing. Immunogenetics 1995, 41:178-228.
21. Jung G, Beck-Sickinger AG: Multiple peptide synthesis methods and their application. Angew Chem (Int Ed) 1992, 31:367-383.
22. Hosmalin A, Clerici M, Houghton R, et al.: An epitope in human immunodeficiency virus 1 reverse transcriptase recognized by both mouse and human cytotoxic T lymphocytes. Proc Natl Acad Sci USA 1990, 87:2344-2348.
23. Hosmalin A, Kumar S, Barnd D, Volvovitz F, Miller L, Berzofsky JA: Immunizing with soluble protein-incubated spleen cells induces responses to the same class I-restricted CTL that recognize immunodominant epitopic peptides from P. falciparum and HIV-1. J Immunol 1992, 149:1311-1318.
24. Haas G, David R, Frank R, et al.: Identification of a major human immunodeficiency virus-1 reverse transcriptase epitope recognized by mouse CD4+ lymphocytes. Eur J Immunol 1991, 21:1371-1377.
25. Tsomides TJ, Aldovini A, Johnson RP, Walker BD, Young RA, Eisen HN: Naturally processed viral peptides recognized by cytotoxic T lymphocytes cells chronically infected by human immunodeficiency virus type 1. J Exp Med 1994, 180:1283-1293.
26. Kageyama S, Tsomides TJ, Sykulev Y, Eisen HN: Variations in the number of peptide-MHC class I complexes required to activate cytolytic T cell responses. J Immunol 1995, 154:567-576.
27. 3CSS induce in vivo B and T helper cell responses to HIV-1 reverse transcriptase. Immunobiol 1995, 195:61-76.
28. Kozal MJ, Shah N, Shen N, et al.: Extensive polymorphisms observed in HIV-1 clade B protease gene using high-density oligonucleotide arrays. Nature Med 1996, 2:753-759.
29. Joly P, Guillon JM, Mayaud C, et al.: Cell mediated suppression of HIV-specific cytotoxic T lymphocytes. J Immunol 1989, 143:2193-2201.
30. Carmichael A, Jin X, Sissons B, Borysiewicz L: Quantative analysis of the human immunodeficiency virus type 1 (HIV-1) specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: Differential CTL responses to HIV and Ebstein-Barr virus in late disease. J Exp Med 1993, 177:249-256.
31. Rinaldo CJ, Beltz LA, Huang XL, Gupta P, Fan Z, Torpey DR: Anti-HIV type 1 cytotoxic T-lymphocyte effector activity and disease progression in the first 8 years of HIV type 1 infection of homosexual men. AIDS Res Hum Retroviruses 1995, 11:481-489.
32. Klein MR, VanBaalen CA, Holwerda AM, et al.: Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics. J Exp Med 1995, 181:1365-1372.
33. Brander C, Walker BD: The HLA class I restricted CTL response in HIV-1 infection: systematic identification of optimal epitopes. In Human Retroviruses and AIDS Suppl IV. Los Alamos: Los Alamos National Laboratory; December 1996.
34. Harrer E, Harrer T, Barbosa P, et al.: Recognition of the highly conserved YMDD region in the human immunodeficiency virus type 1 reverse transcriptase. by HLA-A2-restricted cytotoxic T lymphocytes from an asymptomatic long-term nonprogressor. J Infect Dis 1996, 173:476-479.
35. Van der Burg SH, Klein MR, Van de Velde CJ, Kast WM, Miedema F, Melief CF: Induction of a primary human cytotoxic T-lymphocyte response against a novel conserved epitope in a functional sequence of HIV-1 reverse transcriptase. AIDS 1995, 9:121-127.
36. Rowland-Jones S, Sutton J, Ariyoshi, K et al.: HIV-specific cytotoxic T cells in HIV-exposed but uninfected Gambian women. Nature Med 1995, 1:59-64.
37. Sipsas NV, Kalams SA, Trocha A, et al.: Identification of type-specific cytotoxic T cell responses in homologous viral proteins in laboratory workers accidentally infected with the human immunodeficiency virus-1. J Clin Invest 1997, 99:752-762.
38. Kaslow RA, Carrington M, Apple R, et al.: Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection. Nature Med 1996, 2:405-411.
39. Nowak MA, May RM, Phillips RE, et al.: Antigenic oscillations and shifting immunodominance in HIV-1 infections. Nature 1995, 375:606-611.
40. Goulder PJR, Phillips RE, Colbert R, et al.: Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS. Nature Med 1997, 3:212-217.