Critical point mutations for hepatitis C virus NS3 proteinase

Virology

Volumn 246, Issue 1, 1998, Pages 104-112

  Yamada, Kazunori ^a   Mori, Akiko ^a   Seki, Makoto ^a   Kimura, Junko ^a   Yuasa, Satoshi ^a   Matsuura, Yoshiharu ^b   Miyamura, Tatsuo ^b  

^a MITSUBISHI CHEMICAL CORPORATION   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ARGININE; CHIMERIC PROTEIN; COMPLEMENTARY DNA; GLYCINE; MALTOSE BINDING PROTEIN; PROLINE; PROTEIN A; PROTEINASE; THREONINE; VIRUS PROTEIN;

ARTICLE; ENZYME ACTIVE SITE; ESCHERICHIA COLI; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ESCHERICHIA; ESCHERICHIA COLI; HEPATITIS C VIRUS; RNA VIRUSES;

EID: 0032551240     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1998.9184     Document Type: Article

References (28)

1. Bazan, J. F., and Fletterick, R. J. (1990). Structural and catalytic models of trypsin-like viral proteases. Semin. Virol. 1, 311-322.
2. Bartenschlager, R., Ahlborn-Lakke, L., Mous, J., and Jacobsen, H. (1993). Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions. J. Virol. 67, 3835-3844.
3. Bartenschlager, R., Lohmann, V., Wilkinson, T., and Koch, J. O. (1995). Complex formation between the NS3 serine-type proteinase of the hepatitis C virus and NS4A and its importance for polyprotein maturation. J. Virol. 69, 7519-7528.
4. Bukh, J., Miller, R. H., and Purcell, R. H. (1995). Genetic heterogeneity of hepatitis C virus: Quasispecies and genotypes. Semin. Liver Dis. 15, 41-63.
5. Chambers, T. J., Hahn, C., Galler, R., and Rice, C. M. (1990). Flavivirus genome organization, expression, and replication. Annu. Rev. Microbiol. 44, 649-688.
6. Choo, Q.-L., Kuo, G., Weiner, A. J., Overby, L. R., Bradley, D. W., and Houghton, M. (1989). Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 244, 359-362.
7. Choo, Q.-L., Richman, K. H., Man, J. H., Berger, K., Lee, C., Dong, C., Gallegos, C., Coit, D., Medina-Selby, A., Barr, P. J., Weiner, A. J., Bradley, D. W., Kuo, G., and Houghton, M. (1991). Genetic organization and diversity of the hepatitis C virus. Proc. Natl. Acad. Sci. USA 88, 2451-2455.
8. Grakoui, A., McCourt, D. W., Wychowski, C., Feinstone, S. M., and Rice, C. M. (1993a). A second hepatitis C virus-encoded proteinase. Proc. Natl. Acad. Sci. USA 90, 10583-10587.
9. Grakoui, A., Wychowski, C., Lin, C., Feinstone, S. M., and Rice, C. M. (1993b). Expression and identification of hepatitis C virus polyprotein cleavage products. J. Virol. 67, 1385-1395.
10. Grakoui, A., McCourt, D. W., Wychowski, C., Feinstone, S. M., and Rice, C. M. (1993c). Characterization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sites. J. Virol. 67, 2832-2843.
11. Hijikata, M., Mizushima, H., Akagi, T., Mori, S., Kakiuchi, N., Kato, N., Tanaka, T., Kimura, K., and Shimotohno, K. (1993a). Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus. J. Virol. 67, 4665-4675.
12. Hijikata, M., Mizushima, H., Tanji, Y., Komoda, Y., Hirowatari, Y., Akagi, T., Kato, N., Kimura, K., and Shimotohno, K. (1993b). Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus. Proc. Natl. Acad. Sci. USA 90, 10773-10777.
13. Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K., and Pease, L. R. (1989). Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77, 51-59.
14. Kato, N., Hijikata, M., Ootsuyama, Y., Nakagawa, M., Ohkoshi, S., Sugimura, T., and Shimotohno, K. (1990). Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis. Proc. Natl. Acad. Sci. USA 87, 9524-9528.
15. Kim, J. L., Morgenstern, K. A., Lin, C., Fox, T., Dwyer, M. D., Landro, J. A., Chambers, S. P., Markland, W., Lepre, C. A., O'Malley, E. T., Harbeson, S. L., Rice, C. M., Murcko, M. A., Caron, P. R., and Thomson, J A. (1996). Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide. Cell 87, 343-355.
16. Kuo, G., Choo, Q.-L., Alter, H. J., Gitnick, G. L., Redecker, A. G., Purcell, R. H., Miyamura, T., Dienstag, J. L., Alter, M. J., Stevens, C. E., Tegtmeier, G. E., Bonino, F., Colombo, M., Lee, W.-S., Kuo, C., Berger, K., Shuster, J. R., Overby, L. R., Bradley, D. W., and Houghton, M. (1989). An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science 244, 362-364.
17. Love, R. A., Parge, H. E., Wickersham, J. A., Hostomsky, Z., Habuka, N., Moomaw, E. W., Adachi, T., and Hostomska, Z. (1996). The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site. Cell 87, 331-342.
18. Manabe, S., Fuke, I., Tanishita, O., Kaji, C., Gomi, Y., Yoshida, S., Mori, C., Takamizawa, A., Yoshida, I., and Okayama, H. (1994). Production of nonstructural proteins of hepatitis C virus requires a putative viral protease encoded by NS3. Virology 198, 636-644.
19. Matsuura, Y., and Miyamura, T. (1993). The molecular biology of hepatitis C virus. Semin. Virol. 4, 297-304.
20. Miller, R. H., and Purcell, R. H. (1990). Hepatitis C virus shares amino acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups. Proc. Natl. Acad. Sci. USA 87, 2057-2061.
21. Mori, A., Yamada, K., Kimura, J., Koide, T., Yuasa, S., Yamada, E., and Miyamura, T. (1996). Enzymatic characterization of purified NS3 serine proteinase of hepatitis C virus expressed in Escherichia coli. FEBS Lett. 378, 37-42.
22. Mori, A., Yuasa, S., Yamada, K., Nagami, Y., and Miyamura, T. (1997). The N-terminal region of NS3 serine proteinase of hepatitis C virus is important to maintain its enzymatic integrity. Biochem. Biophys. Res. Commun. 231, 738-742.
23. Rice, C. M. (1996). Flaviviridae: The viruses and their replication. In "Virology," pp. 931-960. In (B. N. Fields, D. M. Knipe, and P. M. Howley, (Eds.). Raven Press, New York.
24. Saito, I., Miyamura, T., Ohbayashi, A., Harada, H., Katayama, T., Kikuchi, S., Watanabe, T. Y., Koi, S., Onji, M., Ohta, Y. et al. (1990). Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc. Natl. Acad. Sci. USA 87, 6547-6549.
25. Takamizawa, A., Mori, C., Fuke, I., Manabe, S., Murakami, S., Fujita, J., Onishi, E., Andoh, T., Yoshida, I., and Okayama, H. (1991). Structure and organization of the hepatitis C virus genome isolated from human carriers. J. Virol. 65, 1105-1113.
26. Takeuchi, K., Kubo, Y., Boonmar, S., Watanabe, Y., Katayama, T., Choo, Q.-L., Kuo, G., Houghton, M., Saito, I., and Miyamura, T. (1990). The putative nucleocapsid and envelope protein genes of hepatitis C virus determined by comparison of the nucleotide sequences of two isolates derived from an experimentally infected chimpanzee and healthy human carriers. J Gen. Virol. 71, 3027-3033.
27. Tanji, Y., Hijikata, M., Hirowatari, Y., and Shimotohno, K. (1994). Identification of the domain required for frans-cleavage activity of hepatitis C virus serine proteinase. Gene 145, 215-219.
28. Tomei, L., Failla, C., Santolini, E., De Francesco, R., and La Monica, N. (1993). NS3 is a serine proteinase required for processing of hepatitis C virus polyprotein. J. Virol. 67, 4017-4026.