Biotransformation of octane by E. coli Hb101[pGEc47] on defined medium: Octanoate production and product inhibition

Biotechnology and Bioengineering

Volumn 58, Issue 4, 1998, Pages 356-365

  Rothen, S A ^a,b   Sauer, M ^a,c   Sonnleitner, B ^a,d   Witholt, B ^a  

^a ETH ZURICH   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

^c UNIVERSITY OF VIENNA   (Austria)

^d Abteilung für Chemie   (Switzerland)

Author keywords

Batch and continuous cultivation; Bioconversion; Defined medium; Escherichia coli HB101 pGEc47 ; Linear inhibition kinetics; Model simulation; Octanoic acid; Transient experiments

Indexed keywords

BATCH CELL CULTURE; BIOMASS; COLIFORM BACTERIA; COMPUTER SIMULATION; CONTINUOUS CELL CULTURE; FATTY ACIDS; GLUCOSE; GROWTH KINETICS; PARAFFINS;

LINEAR INHIBITION KINETICS; OCTANE; OCTANOATE; OCTANOIC ACID;

BIOCONVERSION;

GLUCOSE; OCTANE; OCTANOIC ACID;

ARTICLE; BACTERIUM CULTURE; BIOMASS; BIOTRANSFORMATION; CULTURE MEDIUM; ESCHERICHIA COLI; GLUCOSE INTAKE; NONHUMAN;

BIOREACTORS; BIOTRANSFORMATION; CULTURE MEDIA; ESCHERICHIA COLI; GLUCOSE; KINETICS; MODELS, BIOLOGICAL; OCTANES; OCTANOIC ACIDS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0032550836     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19980520)58:4<356::AID-BIT2>3.0.CO;2-I     Document Type: Article

References (31)

1. Bhaskar, G. V., Rao-Bhumidimarri, S. M. 1991. Approximate analytical solutions for a biofilm reactor model with Monod kinetics and product inhibition. Can. J. Chem. Eng. 69; 544-547.
2. Borzani, W. 1995. Product inhibition during the feeding phase in fed-batch ethanol fermentation of sugarcane blackstrap molasses. Biotechnol. Lett. 17: 1295-1298.
3. Boyer, H. W., Roulland-Dussoix, D. 1969. A complementation analysis of the restriction and modification of DNA in Escherichia coli. J. Mol. Biol. 41: 459-472.
4. Chen, Q., Janssen, D. B., Witholt, B. 1995. Growth on octane alters the membrane lipid fatty acids of Pseudomonas oleovorans due to the induction of alkB and synthesis of octanol. J. Bacterol. 177: 6894-6901.
5. Eggink, G., Lageveen, R. G., Altenburg, B., Witholt, B. 1987. Controlled and functional expression of a P. oleovorans alkane utilizing system in Pseudomonas putida and Escherichia coli. J. Biol. Chem. 262: 17712-17718.
6. Favre-Bulle, O., Schouten, T., Kingma, J., Witholt, B. 1991. Bioconversion of n-octane to octanoic acid by a recombinant Escherichia coli cultured in a two-liquid phase bioreactor. Bio/Technology 9; 367-371.
7. Favre-Bulle, O., Weenink, E., Vos, T., Preusting, H., Witholt, B. 1993. Continuous bioconversion of n-octane to octanoic acid by recombinant Escherichia coli (alk+) growing in a two-liquid phase chemostat. Biotechnol. Bioeng. 41: 263-272.
8. Favre-Bulle, O., Witholt, B. 1992. Biooxidation of n-octane by a recombinant Escherichia coli in a two-liquid-phase system: Effect of medium components on cell growth and alkane oxidation activity. Enzyme Microb. Technol. 14: 931-937.
9. Fond, O., Jansen, N. B., Tsao, G. T. 1985. A model of acetic acid and 2,3-butanediol inhibition of the growth and metabolism of Klebsiella oxytoca, Biotechnol. Lett. 7: 727-732.
10. Gram, A. 1996. Biochemical engineering and industry. Abstract book. First European Symposium on Biochemical Engineering Sciences, Dublin, Ireland.
11. Gschaedler, A., Boudrant, J. 1994. Amino acid utilization during batch and continuous cultures of Escherichia coli on a semi-synthetic medium. J. Biotechnol. 37:235-251.
12. Hamamci, H., Ryu, D. D. Y. 1994. Production of L(+)-lactic acid using immobilized Rhizopus oryzae: Reactor performance based on kinetic model and simulation. Appl. Biochem. Biotechnol. 44: 125-133.
13. Hoeks, F. W. J. M. M., Muhle, J., Böhlen, L., Psenicka, I. 1996. Process integration aspects for the production of fine chemicals illustrated with the biotransformation of gamma butyrobetaine into L-carnitine. Chem. Eng. 61: 53-61.
14. Kuhn, R. Peretti, S., Ollis, D. 1993. Acid inhibition of immobilized cells: Quantitative comparison of model and experiment. Appl. Biochem. Biotechnol. 39/40: 401-413.
15. Lee, K. J., Rogers, P. L. 1983. The fermentation kinetics of ethanol production by Zymomonas mobilia. Chem. Eng. J. 27: B31-B38.
16. Locher, G., Sonnleitner, B., Fiechter, A. 1991. Automatic bioprocess control. 2. Implementation and practical experiences. J. Biotechnol. 19: 127-144.
17. Misset, O., Lenting, H. B. M., Labout, J. J. M., Bolle, R., Oomen, A. J. A. M., Mulleners, L. J. S. M. 1993. Application of lipases in household detergents, Fat-Sci. Technol. 95; 419-420.
18. Münch, T., Sonnleitner, B., Fiechter, A. 1992. The decisive role of the Saccharomyces cerevisiae cell cycle behavior for dynamic growth characterization. J. Biotechnol. 22: 329-352.
19. Nieboer, M., Kingma, J., Witholt, B. 1993. The alkane oxidation system of Pseudomonas oleovorans; Induction of the alk genes in Escherichia coli W3110[pGEc47] affects membrane biogenesis and results in overexpression of alkane hydroxylase in a distinct cytoplasmatic membrane subfraction. Mol. Microbiol. 8: 1039-1051.
20. Richter, K., Becker, U. 1985. Inhibition in alcoholic fermentation: i. Influence of ethanol concentration on the specific rate of ethanol formation in Saccharomyces cerevisiae. Acta Biotechnol. 5: 9-17.
21. Rohner, M., Meyer, H. P. 1995. Applications of modeling for bioprocess design and control in industrial production. Bioproc. Eng. 13: 69-78.
22. Rothen, S. A., Saner, M., Meenakshisundaram, S., Sonnleitner, B., and Fiechter, A. 1996. Glucose uptake kinetics of Saccharomyces cerevisiae monitored with a newly developed FIA. J. Biotechnol. 50: 1-12.
23. Seo, J. H., Bailey, J. E. 1985. Effects of recombinant plasmid content on growth properties and cloned gene product formation in Escherichia coli. Biotechnol. Bioeng. 27: 1668-1674.
24. Shukla, H., Chaplin, M. 1993. Noncompetitive inhibition of betagalactosidase. Enzyme Microb. Technol. 15: 297-299.
25. Sonnleitner, B., Fiechter, A. 1988. High performance bioreactors: A new generation. Anal. Chim. Acta 213: 199-205.
26. Sonnleitner, B., Locher, G., Fiechter, A. 1991. Automatic bioprocess control. 1. A general concept. J. Biotechnol. 19: 1-18.
27. Stefuca, V., Bales, V. 1990. Hydrolysis of sucrose by yeast invertase: Kinetic data analysis. Prog. Biotechnol. 6: 263-271.
28. van den Heuvel, J. C., Beeftink, H. H., Verschuren, P. G. 1988. Inhibition of the acidogenic population during waste-water waste disposal. Appl. Microbiol. Biotechnol. 29: 89-94.
29. Viegas, C. A., Sà-Correia, I. 1995. Toxicity of octanoic acid in Saccharomyces cerevisiae at temperatures between 8.5 and 30°C. Enz. Microb. Technol. 17: 826-831.
30. Wubbolts, M., Favre-Bulle, O., Witholt, B. 1996. Biosynthesis ofsynthons in two-liquid phase media. Biotechnol. Bioeng. 52: 301-308.
31. Yamane, T., Hibino, W., Ishihara, K., Kadotani, Y., Kominami, M. 1992. Fed-batch culture automated by uses of continuously measured cell concentration and culture volume. Biotechnol. Bioeng. 39: 550-555.