Characterization of muscarinic receptors mediating the contraction of the urinary detrusor muscle in cynomolgus monkeys and guinea pigs

Life Sciences

Volumn 62, Issue 13, 1998, Pages 1179-1186

  Lai, Fong M ^a   Cobuzzi, Agnes ^a   Spinelli, Walter ^a  

^a PFIZER INC   (United States)

Author keywords

4 diphenylacetoxy N methylpiperidine hydrochloride; Detrusor muscle; Guinea pig; Mecthoctramine; Monkey; Muscarinic receptor; Pirenzepin

Indexed keywords

4 DIPHENYLACETOXY 1 METHYLPIPERIDINE; ATROPINE; CARBACHOL; METHOCTRAMINE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; PIRENZEPINE;

ANIMAL TISSUE; ARTICLE; BLADDER CONTRACTION; CONTROLLED STUDY; DETRUSOR DYSSYNERGIA; DETRUSOR MUSCLE; DRUG POTENCY; DRUG RECEPTOR BINDING; GUINEA PIG; MONKEY; NONHUMAN; URINE INCONTINENCE;

ANIMALS; CARBACHOL; DIAMINES; FEMALE; GUINEA PIGS; MACACA FASCICULARIS; MALE; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PIPERIDINES; PIRENZEPINE; RECEPTOR, MUSCARINIC M2; RECEPTORS, MUSCARINIC; URINARY BLADDER;

ANIMALIA; CAVIA; CAVIA PORCELLUS; MACACA FASCICULARIS; SUS SCROFA;

EID: 0032549137     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(98)00044-7     Document Type: Article

References (21)

1. 1. E. C. HULME, N. J. M. BIRDSALL and N. J. BUCKLEY, Ann. Rev. Pharmacol. Toxicol. 30 633-673 (1990).
2. 2. M. P. CAULFIELD, Pharmacol. Therap. 58 319-379 (1993).
3. 3. R. HAMMER, C. P. BERRIE, N. J. M. BIRDSALL, A. S. V. BURGEN and E. C. HULME, Nature , 283 90-92 (1980).
4. 4. C. MELCHIORRE, P. ANGLI, G. LAMBRECHT, E. MUTSCHLER, M. T. PICCHIO and J. WESS, Eur. J. Pharmacol. 144 117-124 (1987).
5. 5. R. B. BARLOW, L. S. MCMILLEN and M.A. VEALE, Br. J. Pharmacol. 102 657-662 (1991).
6. 6. T. I. BONNER, N. J. BUCKLEY, A. C. YOUNG and M. R. BRANN. Science, 237 527-532 (1987).
7. 7. M. WAELBROECK, M. TASTENOY, J. TASTENOY and J. CHRISTOPHE, Mol. Pharmacol. 38 267-273 (1990).
8. 8. R. M. EGLEN, S. S. HEGDE, and N. WATSON, Pharmacol. Rev. 48 531-565 (1996).
9. 9. E. MONFERINI, E. GIRALDO and H. LADINSKY, Eur. J. Pharmacol. 147 453-485 (1988)
10. 10. S. BATRA, Eur. J. Pharmacol. 138 83-88 (1987)
11. 11. L. NILVEBRANT and B. SPARF B. Acta Pharmacol Toxicol. 53 304-313 (1988).
12. 12. M. R. RUGGIERI and G. R. LUTHIN, FASEB J. 4 4372 (1990)
13. 13. A. MAEDA, T. KUBO, M. MASAYOSHI and N. SHOSAKU, FEBS lett., 239 339-342 (1988).
14. 14. S. J. WANG, G. R. LUTHIN and M. R. RUGGIERI, J. Pharmacol. Exp. Ther. 273 959-966 (1995).
15. 15. P. A. LONGHURST, R. E. LEGGETT and J. A. K. BRISCOE, Br. J. Pharmacol. 116 2279-2285 (1995).
16. 16. L. NORONHA-BLOB, V. LOWE, A. PATTON, B. CANNING, D. COSTELLO and W. J. KINNIER, J. Pharmacol Exp. Ther. 249 843-851 (1989).
17. 17. O. ARUNLAKSHANA and H.O. SCHILD, Br. J. Pharmacol. Chemother. 14 48-58 (1959)
18. 18. R. F. FURCHGOTT, in: Catecholamines (ED. by H. and Muscholl), pp.283-335, Springer-Verlag, Berlin (1972)
19. 19. G.D.R. STEEL and J. H. TORRIE, Principles and Procedures of Statistics: A Biometrical Approach, 2nd ed. (McGraw-Hill, New York) 1980.
20. 20. M. DEL TACCA, R. DANESI, C. BLANDEZI and M. C. BERNARDINI. Pharmacol. 40 241-249 (1990)
21. 21. N. A. DOROFEEVA, S. A. SHELKOVNIKOV, L. A. STARSHINOVA, A. F. DANILOV, J. NEDOMA and S. TUCEK. Schmiedelbergs's Arch Pharmacol. 346 383-390 (1992)