Quaternary substituted PDE4 inhibitors I: The synthesis and in vitro evaluation of a novel series of oxindoles

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 2, 1998, Pages 175-178

  Hulme, Christopher ^b   Poli, Gregory B ^a   Huang, Fu Chih ^a   Souness, John E ^b   Djuric, Stevan W ^a  

^a SANOFI   (France)

^b Rhone Poulenc Rorer Ctrl Research   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

OXINDOLE DERIVATIVE; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; DRUG CONFORMATION; DRUG SYNTHESIS; ENZYME ACTIVITY; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; INDOLES; PHOSPHODIESTERASE INHIBITORS; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032548476     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)10206-2     Document Type: Article

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