Induction of cytotoxic oxidative stress by D-alanine in brain tumor cells expressing Rhodotorula gracilis D-amino acid oxidase: A cancer gene therapy strategy

Human Gene Therapy

Volumn 9, Issue 2, 1998, Pages 185-193

  Stegman, Lauren D ^a   Zheng, Hong ^a   Neal, Eric R ^a   Ben Yoseph, Oded ^a   Pollegioni, Loredano ^b   Pilone, Mirella S ^b   Ross, Brian D ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID OXIDASE; COMPLEMENTARY DNA; GLUTATHIONE; HYDROGEN PEROXIDE;

ANIMAL CELL; ARTICLE; CANCER; CELL CLONE; CYTOTOXICITY; DNA TRANSFECTION; GENE THERAPY; GLIOMA CELL; NONHUMAN; OXIDATIVE STRESS; RAT; RHODOTORULA; TUMOR CELL;

ANIMALIA; MAMMALIA; RHODOSPORIDIUM TORULOIDES;

EID: 0032548411     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1998.9.2-185     Document Type: Article

References (6)

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3. BECKMAN, K.B., and AMES, B.N. (1997). Oxidative decay of DNA. J. Biol. Chem. 272, 19633-19636.
4. BEN-YOSEPH, O., and ROSS, B.D. (1994). Oxidation therapy: The use of a reactive oxygen species-generating enzyme system for tumour treatment. Br. J. Cancer 70, 1131-1135.
5. BEN-YOSEPH, O., BOXER, P.A., and ROSS, B.D. (1994a). Oxidative stress in the central nervous system: monitoring the metabolic response using the pentose phosphate pathway. Dev. Neurosci. 16, 328-336.
6. BEN-YOSEPH, O., KINGSLEY, P.B., CAMP, D.M., ROBINSON, T.E., and ROSS, B.D. (1994b). Measurement of pentose phosphate pathway activity by microdialysis in vivo and in a single incubation in vitro. Neurosci. Prot. 94-060-02, 1-13.