Merrifield MicroTube(TM) reactors for solid phase synthesis

Tetrahedron Letters

Volumn 39, Issue 47, 1998, Pages 8581-8584

  Li, Rongshi ^a   Xiao, Xiao Yi ^a   Czarnik, Anthony W ^a  

^a IRORI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORIDE ION; CHLOROMETHYL METHYL ETHER; POLYPROPYLENE; POLYSTYRENE;

ARTICLE; ELECTRODE; POTENTIOMETRY; RADIOFREQUENCY; REACTOR; SYNTHESIS; TUBE;

EID: 0032548131     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)01963-7     Document Type: Article

References (16)

1. th ACS National Meeting, ORGN 291, September 7-11, 1997, Las Vegas, NV., and at the CHI Third Annual High-Throughput Organic Synthesis, March 5-6, 1998, Loews Coronado Bay Resort, Coronado, CA.
2. 2. DeWitt, S. H.; Czarnik, A. W. Editors, A Practical Guide to Combinatorial Chemistry, ACS Books, Washington, 1997.
3. 3. Gordon, E. M.; Barrett, R. W.; Dower, W. J.; Fodor, S. P. A.; Gallop, M. A. J. Med. Chem. 1994, 37, 1385.
4. 4. Gordon, E. M.; Gallop, M. A.; Patel, D. V. Acc. Chem. Res. 1996, 29, 144.
5. 5. Thompson, L. A.; Ellman, J. A. Chem. Rev. 1996, 96, 555.
6. 6. Xiao, X-Y.; Zhao, C.; Potash, H.; Nova, M. P. Angew. Chem. Int. Ed. Engl. 1997, 36, 780.
7. 7. Nicolaou, K. C.; Xiao, X-Y.; Parandoosh, Z.; Senyei, A.; Nova, M. P. Angew. Chem. Int. Ed. Engl. 1995, 34, 2289.
8. 8. Moran, E. J.; Sarshar, S.; Cargill, J. F.; Shahbaz, M. M.; Lio, A.; Mjalli, A. M. M.; Armstrong, R. W. J. Am. Chem. Soc. 1995, 117, 10787.
9. 9. Feinberg, R. S.; Merrifield, R. B. Tetrahedron, 1974, 30, 3209.
10. -] sample measurements). Typical Merrifield MicroTube™ reactors have a loading of 30 μmol ± 10% RSD (Relative Standard Deviation).
11. 11. Sparrow, J. T. Tetrahedron Lett. 1975, 52, 4637.
12. 12. Wright, M. E.; Toplikar, E. G.; Svejda, S. A. Macromolecules, 1991, 24, 5879.
13. 13. Gisin, B. F. Helv. Chim. Acta, 1973, 56, 1476.
14. 14. Backes, B. J.; Ellman, J. A. J. Am. Chem. Soc. 1994, 116, 11171.
15. 15. Chen, C.; Randall, L. A. A.; Miller, R. B.; Jones, A. D.; Kurth, M. J. J. Am. Chem. Soc. 1994, 116, 2661.
16. 16. Nicolaou, K. C.; Vourloumis, D.; Li, T.; Pastor, J.; Winssinger, N.; He, Y.; Ninkovic, S.; Sarabia, F.; Vallberg, H.; Roschangar, F.; King, N. P.; Finlay, R. V.; Giannakakou, P.; VerdierPinard, P.; Hamel, E. Angew. Chem. Int. Ed. Engl. 1997, 36, 2097.