Novel synthesis of 4-oxo-1-isoquinolone derivatives utilizing inter- and intramolecular tandem carbopalladation-heterocyclic ring expansion

Tetrahedron Letters

Volumn 39, Issue 47, 1998, Pages 8677-8680

  Jeong, Ill Yun ^a   Nagao, Yoshimitsu ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Allenes; Aryl halides; Heck reactions; Ring transformations

Indexed keywords

HETEROCYCLIC COMPOUND; ISOQUINOLINE DERIVATIVE; PALLADIUM; POLYCYCLIC AROMATIC HYDROCARBON;

ARTICLE; CHEMICAL REACTION; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ANALYSIS; SYNTHESIS;

EID: 0032548124     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)01870-X     Document Type: Article

References (27)

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25. 4, and filtered. The filtrate was evaporated in vacua to afford the crude product, which was purified by flash column chromatography on silica gel with etner-hexane (1:3) to give 4-oxo-1-isoquinolone 2 (R = Et, Ar = p-MePh)(0.19 g, 90 % yield) as a pale yellow oil.
26. w = 0.085, GOF = 1.76
27. +).