The MEK inhibitor PD 098059 inhibits prolactin-induced Nb2 cell mitogenesis but not milk product synthesis in cultured mouse mammary tissues

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1448, Issue 1, 1998, Pages 126-134

  Yu, T X ^a   Rillema, J A ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

MAP kinase pathway; Map Erk kinase kinase; Mouse mammary gland; Nb2 cell; Prolactin

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; GROWTH INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; PROLACTIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BREAST; BREAST MILK; CULTURE MEDIUM; DRUG CONCENTRATION; FEMALE; IMMUNOPRECIPITATION; MAMMARY GLAND; MILK PRODUCTION; MITOGENESIS; MOUSE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROLACTIN SECRETING CELL;

ANIMALS; CELL DIVISION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FEMALE; FLAVONOIDS; LACTATION; MAMMARY GLANDS, ANIMAL; MAP KINASE KINASE 1; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PROLACTIN; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION;

EID: 0032547967     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4889(98)00116-5     Document Type: Article

References (28)

1. Berridge M.J. Biochim. Biophys. Acta. 907:1987;33-45.
2. Nishizuka Y. J. Natl. Cancer Inst. 76:1986;363-370.
3. Rillema J.A., Waters S.B., Tarrant T.M. Proc. Soc. Exp. Biol. Med. 192:1989;140-144.
4. Guy G.R., Gordon J., Walker L., Micheal R.H., Brown G. Biochem. Biophys. Res. Commun. 135:1986;146-153.
5. Camarillo I.G., Linebaugh B.E., Rillema J.A. Proc. Soc. Exp. Biol. Med. 215:1997;198-202.
6. Rillema J.A., Tarrant T.M., Linebaugh B.E. Biochim. Biophys. Acta. 1014:1989;78-82.
7. Das R., Vonderhaar B.K. Breast Cancer Res. Treat. 40:1996;41-49.
8. Ali S., Pelligrini I., Kelly P.A. J. Biol. Chem. 266:1991;20110-20117.
9. Got P.W., Noble R.L., Beer C.T. Biochem. Cell. Biol. 64:1985;659-666.
10. Clevenger C.V., Torigoe T., Reed J.C. J. Biol. Chem. 269:1994;5559-5565.
11. Rillema J.A., Campbell G.S., Lawson D.M., Carter-Su C. Endocrinology. 131:1992;973-975.
12. Campbell G.S., Argetsinger L.S., Ihle N.J., Kelly P.A., Rillema J.A., Carter-Su C. Proc. Natl. Acad. Sci. U.S.A. 91:1994;5232-5236.
13. DaSilva L., Howard O.M.Z., Rui H., Kirken R.A., Farrar W.L. J. Biol. Chem. 269:1994;18267-18270.
14. Camarillo I.G., Rillema J.A. Proc. Soc. Exp. Biol. Med. 216:1997;98-103.
15. Hang J., Rillema J.A. Biochim. Biophys. Acta. 1358:1997;209-214.
16. Carey G.B., Liberti J.P. Arch. Biochem. Biophys. 316:1995;179-189.
17. Cheng M., Teri G. J. Biol. Chem. 271:1996;8951-8958.
18. Dudley D.T., Pang L., Decker S.J., Brides A.J., Saltiel A.R. Proc. Natl. Acad. Sci. U.S.A. 92:1995;7686-7689.
19. Pang L., Sawada T., Decker S.J., Saltiel A.R. J. Biol. Chem. 270:1995;13585-13588.
20. Parrizas M., Saltiel A.R., LeRoith D. J. Biol. Chem. 272:1997;154-161.
21. Rillema J.A., Yu T.X. Am. J. Physiol. 271:1996;E879-E882.
22. Rillema J.A. Endocrinology. 92:1973;1673-1679.
23. Alessi D.R., Cuenda A., Cohen P., Dudley D.T., Saltiel A.R. J. Biol. Chem. 270:1995;27489-27494.
24. Lazar D.F., Wiese R.J., Brady M.J., Mastick C.C., Waters S.B., Yamauchi K., Pessin J.E., Cuatrecasas P., Saltiel A.R. J. Biol. Chem. 270:1995;20801-20807.
25. Rillema J.A., Rowady D.L. Proc. Soc. Exp. Biol. Med. 215:1997;366-369.
26. J.A. Rillema, R.N. Etindi, J.P. Ofenstein, S.B. Waters, Raven Press, 1988, pp. 2217-2234.
27. Lawson D.M., Sensui N., Haisenleder D.J., Gala R.R. Life Sci. 31:1982;3063.
28. Bligh E.G., Dyer W.J. Can. J. Biochem. Physiol. 37:1959;911-917.