Induction of p21 during ceramide-mediated apoptosis in human hepatocarcinoma cells

Cancer Letters

Volumn 129, Issue 2, 1998, Pages 215-222

  Oh, Won Jong ^a,b   Kim, Won Ho ^a   Kang, Kyung Hwa ^a   Kim, Tae Yun ^a,b   Kim, Mie Young ^a   Choi, Kyung Hee ^a  

^a Chung Ang University   (South Korea)

^b Samsung Medical Center   (South Korea)

Author keywords

Apoptosis; Ceramide; Hepatocarcinoma; p21; p53

Indexed keywords

CERAMIDE; PROTEIN P21; PROTEIN P53;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; GENE INDUCTION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

APOPTOSIS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL DIVISION; CELL SURVIVAL; CERAMIDES; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DNA FRAGMENTATION; GENE EXPRESSION REGULATION; HUMANS; LIVER NEOPLASMS; PHOSPHORYLATION; RETINOBLASTOMA PROTEIN; TIME FACTORS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0032547111     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(98)00105-0     Document Type: Article

References (33)

1. Wiegmann K., Schutze S., Machleidt T., Witte D., Kronke M. Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling. Cell. 78:1994;1005-1015.
2. Tepper C.G., Jayadev S., Liu B., Bielawska A., Wolff R., Yonehara S., Hannun Y.A., Seldin M.F. Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity. Proc. Natl. Acad. Sci. USA. 92:1995;8443-8447.
3. Mathias S., Younes A., Kan C.-C., Orlow I., Joseph C., Kolesnick R.N. Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1β Science. 259:1993;519-522.
4. Haimovitz-Friedman A., Kan C., Ehleiter D., Persaud R., McLoughlin M., Fuks Z., Kolesnick R.N. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. J. Exp. Med. 180:1994;525-535.
5. Obeid L.M., Hannun Y.A. Ceramide: a stress signal and mediator of growth suppression and apoptosis. J. Cell. Biochem. 58:1995;191-198.
6. Hannun Y.A. Functions of ceramide in coordinating cellular responses to stress. Science. 274:1996;1855-1859.
7. Okazaki T., Bell R.M., Hannun Y.A. Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation. J. Biol. Chem. 264:1989;19076-19080.
8. Wiesner D.A., Dawson G. Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway. J. Neurochem. 66:1996;1418-1425.
9. Nickels J.T., Broach J.R. A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae. Genes Dev. 10:1996;382-394.
10. Obeid L.M., Linardic C.M., Karolak L.A., Hannun Y.A. Programmed cell death induced by ceramide. Science. 259:1993;1769-1771.
11. Gomez-Munoz A., Martin A., O'Brien L., Brindley D.N. Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts. J. Biol. Chem. 269:1994;8937-8943.
12. Meikrantz W., Schlegel R. Apoptosis and the cell cycle. J. Cell. Biochem. 58:1995;160-174.
13. King K.L., Cidlowski J.A. Cell cycle and apoptosis: common pathways to life and death. J. Cell. Biochem. 58:1995;175-180.
14. Xiong Y., Hannon G.J., Zhang H., Casso D., Kobayashi R., Beach D. p21 is a universal inhibitor of cyclin kinases. Nature. 366:1993;701-704.
15. El-Deiry W.S., Harper J.W., O'Connor P.M., Velculescu V.E., Canman C.E.et al. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res. 54:1994;1169-1174.
16. Harper J.W., Adami G.R., Wei N., Keyomarsi K., Elledge S.J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 75:1993;805-816.
17. El-Deiry W.S., Tokino T., Velculescu V.E., Levy D.B., Parsons R., Trent J.M., Lin D., Mercer W.E., Kinzler K.W., Vogelstein B. WAF1, a potential mediator of p53 tumor suppression. Cell. 75:1993;817-825.
18. Kuerbitz S.J., Plunkett B.S., Walsh W.V., Kastan M.B. Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc. Natl. Acad. Sci. USA. 89:1992;7491-7495.
19. Michieli P., Chedid M., Lin D., Pierce J.H., Mercer W.E., Givol D. Induction of WAF1/CIP1 by a p53-independent pathway. Cancer Res. 54:1994;3391-3395.
20. Steinman R.A., Hoffman B., Iro A., Guillouf C., Liebermann D.A., El-Houseini M.E. Induction of p21 (WAF-1/CIP1) during differentiation. Oncogene. 9:1994;3389-3396.
21. Jiang H., Lin J., Su Z.-z., Collart F.R., Huberman E., Fisher P.B. Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53. Oncogene. 9:1994;3397-3406.
22. Shao Z.-M., Dawson M.I., Li X.S., Rishi A.K., Sheikh M.S., Han Q.-X., Ordonez J.V., Shroot B., Fontana J.A. p53 independent G0/G1 arrest and apoptosis induced by novel retinoid in human breast cancer cells. Oncogene. 11:1995;493-504.
23. Gartenhaus R.B., Wang P., Hoffmann P. Induction of the WAF1/CIP1 protein and apoptosis in human T-cell leukemia virus type I-transformed lymphocytes after treatment with adriamycin by using a p53-independent pathway. Proc. Natl. Acad. Sci. USA. 93:1996;265-268.
24. Kano A., Watanabe Y., Takeda N., Aizawa S.-i., Akaike T. Analysis of IFN-γ-induced cell cycle arrest and cell death in hepatocytes. J. Biochem. 121:1997;677-683.
25. T. Maniatis, E.F. Fritch, T. Sambrock, Molecular Cloning: A Laboratory Manual, 1989, pp. 1.38-1.39, 6.28-6.29 and 11.23-11.27.
26. Jayadev S., Liu B., Bielawska A.E., Lee J.Y., Nazaire F., Pushkareva M.Y., Obeid L.M., Hannun Y.A. Role for ceramide in cell cycle arrest. J. Biol. Chem. 270:1995;2047-2052.
27. DiGiuseppe J.A., Redston M.S., Yeo C.J., Kern S.E., Hruban R.H. p53-independent expression of the cyclin-dependent kinase inhibitor p21 in pancreatic carcinoma. Am. J. Pathol. 147:1995;884-888.
28. Marchetti A., Doglioni C., Barbareschi M., Buttitta F., Pellegrini S., Bertacca G., Chella A., Merlo G., Angeletti C.A., Palma P.D., Bevilacqua G. p21 RNA and protein expression in non-small cell lung carcinomas: evidence of p53-independent expression and association with tumoral differentiation. Oncogene. 12:1996;1319-1324.
29. Hartwell L.H., Kastan M.B. Cell cycle control and cancer. Science. 266:1994;1821-1828.
30. Dbaibo G.S., Pushkareva M.Y., Jayadev S., Schwarz J.K., Horowitz J.M., Obeid L.M., Hannun Y.A. Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest. Proc. Natl. Acad. Sci. USA. 92:1995;1347-1351.
31. Polyak K., Waldman T., He T.-C., Kinzler K.W., Vogelstein B. Genetic determinants of p53-induced apoptosis and growth arrest. Genes Dev. 10:1996;1945-1952.
32. Dou Q.P., An B., Will P.L. Induction of a retinoblastoma phosphatase activity by anticancer drugs accompanies p53-independent G1 arrest and apoptosis. Proc. Natl. Acad. Sci. USA. 92:1995;9019-9023.
33. Puisieux A., Galvin K., Troalen F., Bressac B., Marcais C., Galun E., Ponchel F., Yakicier C., Ji J., Ozturk M. Retinoblastoma and p53 tumor suppressor genes in human hepatoma cell lines. FASEB J. 7:1993;1407-1413.