Antiinflammatory 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones: Novel inhibitors of COX-2

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 10, 1998, Pages 1181-1186

  Lazer, Edward S ^a   Sorcek, Ronald ^a   Cywin, Charles L ^a   Thome, Diane ^a   Possanza, Genus J ^a   Graham, Anne G ^a   Churchill, Laurie ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 BENZYL 4 SULFONYL 4H ISOQUINOLINE 1,3 DIONE; ANTIINFLAMMATORY AGENT; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; INFLAMMATION; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; EDEMA; ISOENZYMES; ISOQUINOLINES; KINETICS; MEMBRANE PROTEINS; MICROSOMES; MOLECULAR STRUCTURE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0032546519     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00184-X     Document Type: Article

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