Stereoselective synthesis of 4,5-disubstituted pyrrolidin-2-ones by cuprate addition to chiral non racemic α,β-unsaturated-γ-lactams

Tetrahedron Letters

Volumn 39, Issue 8, 1998, Pages 845-848

  Baussanne, Isabelle ^a   Royer, Jacques ^a  

^a CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CUPRATE; GAMMA LACTAM DERIVATIVE; PROLINE DERIVATIVE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; NONHUMAN; STEREOCHEMISTRY;

EID: 0032546137     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)10746-8     Document Type: Article

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26. 4 and concentrated in vacuo. The residue was then purified by flash chromatography on silica gel 60.
27. 11- All new compounds gave satisfactory spectroscopic and analytical (or HRMS) data.
28. 3, 62.5 MHz) δ (ppm) : 178.7, 69.6, 66.5, 36.7, 36.1, 34.9, 29.1, 22.4, 19.6, 13.7.