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Volumn 54, Issue 8, 1998, Pages 1563-1572

Microbiological transformations 40. Use of fungal epoxide hydrolases for the synthesis of enantiopure alkyl epoxides

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL EPOXIDE; EPOXIDE; EPOXIDE HYDROLASE; MICROBIAL ENZYME; UNCLASSIFIED DRUG;

EID: 0032546059     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(97)10394-5     Document Type: Article
Times cited : (37)

References (34)
  • 13
    • 0010699937 scopus 로고    scopus 로고
    • Formerly named Beauveria sulfurescens.
    • 13 Formerly named Beauveria sulfurescens.
  • 16
    • 0010702691 scopus 로고    scopus 로고
    • A complete description of this screening will be published elsewhere
    • 16 A complete description of this screening will be published elsewhere.
  • 19
    • 0010742083 scopus 로고    scopus 로고
    • note
    • 19 In order to keep homogeneity throughout this manuscript, the oxirane ring is numbered with the convention that carbon atom C(1) is bearing the "bigger" substituent, and this convention is kept for the diols, i.e. in this case for 2 and 2a, C(1) is the carbon atom bearing the propyl group.
  • 20
    • 0010656496 scopus 로고    scopus 로고
    • note
    • 20 Because of the very low rate of hydrolysis of (±)-2 using C. globosum (entry 11), and of the low E value obtained with the other fungi (entry 12-14), the kinetic resolution aimed to obtain the optically pure epoxide (R)-2 was not performed.
  • 23
    • 33750247077 scopus 로고    scopus 로고
    • 23 Recently, using a new ligand for the Sharpless asymmetric dihydroxylation, the ee of the diol 4a have been increased to 85%. Becker, H.; Sharpless, K.B. Angew. Chem. Int. Ed. Engl. 1996, 35, 448.
    • (1996) Angew. Chem. Int. Ed. Engl. , vol.35 , pp. 448
    • Becker, H.1    Sharpless, K.B.2
  • 24
    • 0010657650 scopus 로고    scopus 로고
    • The difference between the analytical and the isolated yield for this bioconversion step arises from the high volatility of this product, as previously mentioned
    • 24 The difference between the analytical and the isolated yield for this bioconversion step arises from the high volatility of this product, as previously mentioned.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.