Effects of NMDA and non-NMDA receptor antagonists on the medullary inspiratory neuronal activity during spontaneous augmented breaths in anesthetized rats

Brain Research

Volumn 781, Issue 1-2, 1998, Pages 194-201

  Takeda, Mamoru ^a   Matsumoto, Shigeji ^a  

^a NIPPON DENTAL UNIVERSITY   (Japan)

Author keywords

AP 5; CNQX; Excitatory amino acid; Inspiratory neuron; Iontophoresis; NMDA; Non NMDA; Spontaneous augmented breath

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PENTOBARBITAL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREATHING PATTERN; CELL TYPE; CONTROLLED STUDY; DIAPHRAGM; ELECTROMYOGRAM; MALE; MEDULLA OBLONGATA; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; RESPIRATORY NERVE CELL;

2-AMINO-5-PHOSPHONOVALERATE; 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ANESTHETICS; ANIMALS; EXCITATORY AMINO ACID ANTAGONISTS; IONTOPHORESIS; MALE; MEDULLA OBLONGATA; NEURONS; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; RESPIRATION;

EID: 0032545737     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)01249-3     Document Type: Article

References (25)

1. Bianchi A.L., Denavit-Saubié M., Champagnat J. Central control of breathing in mammals: neuronal circuitry, membrane properties, and neurotransmitter. Physiol. Rev. 75:1995;1-45.
2. Bonham A.C., Coles S.K., McCrimmon D.R. Pulmonary stretch receptor afferents activate excitatory amino acid receptors in the nucleus tractus solitarius in rats. J. Physiol. (London). 464:1993;725-745.
3. Bonham A.C. Neurotransmitter in the CNS control of breathing. Respir. Physiol. 101:1995;219-230.
4. Bartlett D. Jr. Origin and regulation of spontaneous deep breaths. Respir. Physiol. 12:1971;230-238.
5. Cherniack N.S., von Euler C., Glogowska M., Homma I. Characteristics and rate of occurrence of spontaneous and provoked augmented breaths. Acta Physiol. Scand. 111:1981;349-360.
6. Davies A., Roumy M. The effect of transient stimulation of lung irritant receptors on the pattern of breathing in rabbits. J. Physiol. (London). 324:1982;389-401.
7. Ezure K., Manabe M., Yamada H. Distribution of medullary respiratory neurons in the rat. Brain Res. 455:1988;262-270.
8. Faber D.S., Funch P.G., Korn H. Evidence that receptors mediating central synaptic potentials extend beyond the postsynaptic density. Proc. Natl. Acad. Sci. U.S.A. 82:1985;3504-3508.
9. Foutz A.S., Champagnat J., Denabit-Saubié M. Respiratory effects of the N-methyl-D-aspartate (NMDA) antagonist, MK-801, in intact and vagotomized chronic cats. Eur. J. Pharmacol. 154:1988;179-184.
10. Glogowska M., Richardson P.S., Widdicombe J.G., Winning A.J. The role of the vagus nerves, peripheral chemoreceptors and other afferent pathways in the genesis of augmented breaths in cats and rabbits. Respir. Physiol. 16:1972;179-196.
11. Hidebran J.N., Goerke J., Clements J.A. Surfactant release in excited rat lung is stimulated by air inflation. J. Appl. Physiol. 51:1981;905-910.
12. Mayer M.L., Westbrook G.L. The physiology of amino acids in the vertebrate central nervous system. Prog. Neurobiol. 28:1987;197-276.
13. Matsumoto S., Takeda M., Saiki C., Takahashi T., Ojima K. Effects of vagal and carotid chemoreceptor afferents on the frequency and pattern of spontaneous augmented breaths in rabbits. Lung. 175:1997;163-173.
14. Mizusawa A., Ogawa H., Kikuchi Y., Hida W., Kurosawa H., Okabe S., Takishima T., Shirato K. In vivo release of glutamate in nucleus tractus solitarii of the rat during hypoxia. J. Physiol. (London). 478:1994;55-65.
15. Monteau R., Gauthier P., Rega P., Hilaire G. Effects of N-methyl-D-aspartate NMDA antagonist MK-801 on breathing pattern in rat. Neurosci. Lett. 109:1990;134-139.
16. Nowak L., Bregestovski P., Ascher P., Herbet A., Prochiantz A. Magnesium gates glutamate-activated channels in mouse central neurons. Nature. 307:1984;462-465.
17. Orem J., Trotter R.H.J. Medullary respiratory neuronal activity during augmented breaths in intact anesthetized cats. J. Appl. Physiol. 74:1993;761-769.
18. G. Paxinos, C. Watson, The Rat Brain in Stereotaxic Coordinates, Academic Press, Sydney, 1986.
19. Pierrefiche O., Schmid K., Foutz A.S., Denavit-Saubié M. Endogenous activation of NMDA and non-NMDA glutamate receptors on respiratory neurons in cat medulla. Neuropharmacology. 30:1991;429-440.
20. Pierrefiche O., Foutz A.S., Champagnat J., Denavit-Saubié M. NMDA and non-NMDA receptors may play distinct roles in timing mechanisms and transmission in the feline respiratory network. J. Physiol. (London). 474:1994;509-523.
21. Reynolds L.B. Jr. Characteristics of an inspiration-augmenting reflex in anesthetized cats. J. Appl. Physiol. 17:1982;683-688.
22. M.H.T. Roberts, T. Gould, Iontophoresis in the mammalian central nervous system, in: D.I. Wallis (Ed.), Electrophysiology, A Practical Approach, IRL Press, New York, 1993, pp. 239-263.
23. A receptors shape the discharge pattern of bulbar respiratory neurons. Brain Res. 71:1996;150-160.
24. Srinivasan M., Goiny M., Pantalco T., Lagercrantz H., Brodin E., Runold M., Yamamoto Y. Enhanced in vivo release of substance P in the nucleus tractus solitarii during hypoxia in the rabbit: role of peripheral input. Brain. Res. 546:1991;211-216.
25. Takeda M., Matsumoto S. Discharge patterns of dorsal and ventral respiratory group neurons during spontaneous augmented breaths observed in pentobarbital anesthetized rats. Brain Res. 749:1997;95-100.