Insulinresistens os slægtninge til patienter med NIDDM: Betydning af fysisk træningstilstand og muskelmetabolisme

Ugeskrift for Laeger

Volumn 160, Issue 4, 1998, Pages 410-415

  Nyholm, Birgit ^a   Mengel, Annette ^b   Nielsen, Søren ^b   Skjœrbœk, Christian B ^b   Møller, Niels ^b   Alberti, Karl George M M ^b   Schmitz, Ole E ^b  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; COMPARATIVE STUDY; FEMALE; FITNESS; GENETICS; GLUCOSE TOLERANCE TEST; HUMAN; INSULIN RESISTANCE; MALE; METABOLISM; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; OXYGEN CONSUMPTION; SKELETAL MUSCLE;

ADULT; DIABETES MELLITUS, TYPE 2; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN RESISTANCE; MALE; MIDDLE AGED; MUSCLE, SKELETAL; OXYGEN CONSUMPTION; PHYSICAL FITNESS;

EID: 0032545578     PISSN: 00415782     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. DeFronzo RA. The triumvirate: β-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 1988; 37:667-87.
2. Yki-Järvinen H. Pathogenesis of non-insulin-dependent diabetes mellitus. Lancet 1994; 343: 91-5.
3. Beck-Nielsen H, Groop L. Metabolic and genetic characterization of prediabetic states. J Clin Invest 1994; 94: 1714-21.
4. Eriksson J, Franssila-Kallunki A, Ekstrand A, Saloranta C, Widén E, Schalin C et al. Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus. N Engl J Med 1989; 321: 337-43.
5. Laws A, Stefanick ML, Reaven GM. Insulin resistance and hypertriglyceridemia in nondiabetic relatives of patients with non-insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1989; 69: 343-7.
6. Vaag A, Henriksen JE, Beck-Nielsen H. Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin- dependent diabetes mellitus. J Clin Invest 1992; 89: 782-8.
7. Warram JH, Martin BC, Krolewski AS, Soeldner JS, Kahn CR. Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Ann Intern Med 1990; 113: 909-15.
8. Lillioja S, Mott DM, Spraul M, Ferraro R, Foley JE, Ravussin E et al. Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. N Engl J Med 1993; 329: 1988-92.
9. Koivisto VA, Yki-Jarvinen H, DeFronzo RA. Physical training and insulin sensitivity. Diabetes Metab Rev 1986; 1: 445-81.
10. Mikines KJ, Sonne B, Farrell PA, Tronier B, Galbo H. Effect of physical exercise on sensitivity and responsiveness to insulin in humans. Am J Physiol 1988; 254: E248-59.
11. Helmrich SP, Ragland DR, Leung RW, Paffenbarger RS. Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus. N Engl J Med 1991; 325: 147-52.
12. Manson JE, Rimm EB, Stampfer MJ, Colditz GA, Willett WC, Krolewski AS et al. Physical activity and incidence of non-insulin-dependent diabetes mellitus in women. Lancet 1991; 338: 774-8.
13. Laakso M, Edelman SV, Brechtel G, Baron AD. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance. J Clin Invest 1990; 85: 1844-52.
14. Baron AD, Laakso M, Brechtel G, Edelman SV. Reduced capacity and affinity of skeletal muscle for insulin-mediated glucose uptake in non-insulin-dependent diabetic subjects. Effects of insulin therapy. J Clin Invest 1991; 87: 1186-94.
15. Åstrand I. Aerobic work capacity of men and women with special reference to age. Acta Physiol Scand Suppl 1960; 169: 49-92.
16. Finegood DT, Bergman RN, Vranic M. Estimation of endogenous glucose production during hyperinsulinemic-euglycemic glucose clamps, comparison of unlabelled and labelled exogenous glucose infusates. Diabetes 1987, 36: 914-24.
17. Andersen L, Dmesen B, Jørgensen PN, Poulsen F, Røder ME. Enzyme immunoassay for intact human insulin in serum or plasma. Clin Chem 1993; 39: 578-82.
18. Lillioja S, Young AA, Culter CL, Ivy JL, Abbot WGH, Zawadzki JK et al. Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man. J Clin Invest 1987; 80: 415-24.
19. Mårin P, Anderson B, Krotkiewski M, Björntorp P. Muscle fibre composition and capillary density in women and men with NIDDM. Diabetes Care 1994; 17: 382-6.
20. Banerji MA, Chaiken RL, Gordon D, Kral JG, Lebovitz HE. Does intra-abdominal adipose tissue in black men determine whether NIDDM is insulin-resistant or insulin-sensitive? Diabetes 1995, 44: 141-6.