Protein kinase C-ζ activity but not level is decreased in Alzheimer's disease microvessels

Neuroscience Letters

Volumn 254, Issue 1, 1998, Pages 29-32

  Moore, Pete ^a   White, Jay ^a   Christiansen, Victoria ^a   Grammas, Paula ^a  

^a UNIVERSITY OF OKLAHOMA   (United States)

Author keywords

Alzheimer's disease; Microvasculature; Protein kinase C

Indexed keywords

PROTEIN KINASE C;

ALZHEIMER DISEASE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME BLOOD LEVEL; HUMAN; HUMAN TISSUE; MICROVASCULATURE; PRIORITY JOURNAL;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BLOTTING, WESTERN; BRAIN; DENSITOMETRY; ENZYME ACTIVATION; HUMANS; ISOENZYMES; MICROCIRCULATION; MOLECULAR WEIGHT; PRECIPITIN TESTS; PROTEIN KINASE C;

EID: 0032544347     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00653-3     Document Type: Article

References (19)

1. Caporaso, G.L., Gandy, S.E., Buxbaum, J.D., Ramabhadran, T.V. and Greengard, P., Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein, Proc. Natl. Acad. Sci. USA, 89 (1992) 3055-3059.
2. Cashman, R.E. and Grammas, P., cAMP-dependent protein kinase in cerebral microvessels in aging and Alzheimer's disease, Mol. Chem. Neuropathol., 26 (1995) 247-258.
3. Cole, G., Dobkins, K.R., Hansen, LA., Terry, R.D. and Saitoh, T., Decreased levels of protein kinase C in Alzheimer brain, Brain Res., 452 (1988) 165-174.
4. Davda, R.K., Chandler, L.J. and Guzman, N.J., Protein kinase C modulates receptor-independent activation of endothelial nitric oxide synthase, Eur. J. Pharmacol., 266 (1944) 237-244.
5. Dekker, L.V. and Parker, P.J., Protein kinase C - a question of specificity, Trends Biochem. Sci., 19 (1994) 73-77.
6. Dorheim, M.A., Tracey, W.R., Pollock, J.S. and Grammas, P., Nitric oxide synthase activity is elevated in brain microvessels in Alzheimer's disease, Biochem. Biophys. Res. Commun., 205 (1994) 659-665.
7. Grammas, P., Moore, P., Botchlet, T., Hanson-Painton, O., Cooper, D., Ball, M. and Roher, A., Cerebral microvessels in Alzheimer's have reduced protein kinase C activity, Neurobiol. Aging, 16 (1995) 563-569.
8. Grammas, P., Roher, A.E. and Ball, M.J., Alzheimer's Disease: Basic Mechanisms, Diagnosis, and Therapeutic Strategies, Wiley, New York, 1991, pp. 129-136.
9. Greenwood, A.F., Powers, R.E. and Jope, R.S., Phosphoinositide hydrolysis, G alpha q, phospholipase C, and protein kinase C in post mortem human brain: effects of post mortem interval, subject age, and Alzheimer's disease, Neuroscience, 69 (1995) 125-138.
10. Hanson-Painton, O., Morgenstern, K., Cooper, D.R., Moore, P., Botchlet, T. and Grammas, P., Protein kinase C in rat cerebral microvessels, Mol. Chem. Neuropathol., 20 (1993) 245-261.
11. Johshita, H., Asano, T., Matsui, T. and Koide, T., Frontiers in Cerebral Vascular Biology: Transport and its Regulation, Plenum Press, New York, 1993, pp. 61-64.
12. Masliah, E., Cole, G.M., Hansen, L.A., Mallory, M., Albright, T., Terry, R.D. and Saitoh, T., Protein kinase C alteration is an early biochemical marker in Alzheimer's disease, J. Neurosci., 11 (1991) 2759-2767.
13. 2+-independent protein kinase C changes in the brain of patients with Alzheimer's disease, J. Neurochem., 67 (1996) 317-323.
14. Miller, B.W., Baier, L.D. and Morrison, A.R., Overexpression of protein kinase C-zeta isoform increases cyclooxygenase-2 and inducible nitric oxide synthase, Am. J. Physiol., 273 (1997) C130-C136.
15. Mirra, S.S., Hart, M.N. and Terry, R.D., Making a diagnosis of Alzheimer's disease. A primer for practicing pathologists, Arch. Pathol. Lab. Med., 117 (1993) 132-144.
16. Newton, A.C., Regulation of protein kinase C, Curr. Opin. Cell Biol., 9 (1997) 161-167.
17. Nishizuka, Y., Protein kinase C and lipid signaling for sustained cellular responses, FASEB J., 9 (1995) 484-496.
18. Wang, H.-Y., Pisano, M.R. and Friedman, E., Attenuated protein kinase C activity and translocation in Alzheimer's disease, Neurobiol. Aging, 15 (1994) 293-298.
19. 2 integrin gene expression is mediated by protein kinase C-ζ, J. Cell Biol., 134 (1996) 1301-1311.