메뉴 건너뛰기




Volumn 282, Issue 2, 1998, Pages 301-315

Mapping the mAb 383C epitope to α2(187-199) of the Torpedo acetylcholine receptor on the three-dimensional model

Author keywords

3 D epitope mapping; Acetylcholine binding residues; Acetylcholine receptor; Anti acetylcholine receptor monoclonal antibody; mAb epitope mapping

Indexed keywords

ACETYLCHOLINE; ALPHA BUNGAROTOXIN; CARBACHOL; CHOLINERGIC RECEPTOR; EPITOPE; MONOCLONAL ANTIBODY; PROTEIN SUBUNIT; RECEPTOR SUBUNIT;

EID: 0032544333     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1998.2000     Document Type: Article
Times cited : (7)

References (44)
  • 2
    • 0028354441 scopus 로고
    • 2+ ATPase enzyme in the presence of terbium: A time resolved X-ray diffraction study
    • 2+ ATPase enzyme in the presence of terbium: a time resolved X-ray diffraction study. Biophys. J. 66, 1653-1664.
    • (1994) Biophys. J. , vol.66 , pp. 1653-1664
    • Asturias, F.J.1    Fischetti, R.F.2    Blasie, J.K.3
  • 3
    • 0029143458 scopus 로고
    • Three-dimensional location of the main immunogenic region of the acetylcholine receptor
    • Beroukhim, R. & Unwin, N. (1995). Three-dimensional location of the main immunogenic region of the acetylcholine receptor. Neuron, 15, 323-331.
    • (1995) Neuron , vol.15 , pp. 323-331
    • Beroukhim, R.1    Unwin, N.2
  • 5
    • 0031468619 scopus 로고    scopus 로고
    • Identification of amino acids contributing to high and low affinity d-tubocurarine sites in the Torpedo nicotinic acetylcholine receptor
    • Chiara, D. C. & Cohen, J. B. (1997). Identification of amino acids contributing to high and low affinity d-tubocurarine sites in the Torpedo nicotinic acetylcholine receptor. J. Biol. Chem. 272, 32940-32950.
    • (1997) J. Biol. Chem. , vol.272 , pp. 32940-32950
    • Chiara, D.C.1    Cohen, J.B.2
  • 6
    • 0026344986 scopus 로고
    • Structure of the agonist-binding site of the nicotinic acetylcholine receptor
    • Cohen, J. B., Sharp, S. D. & Liu, W. S. (1991). Structure of the agonist-binding site of the nicotinic acetylcholine receptor. J. Biol. Chem. 266, 23354-23364.
    • (1991) J. Biol. Chem. , vol.266 , pp. 23354-23364
    • Cohen, J.B.1    Sharp, S.D.2    Liu, W.S.3
  • 7
    • 0025719155 scopus 로고
    • Agonist binding site of Torpedo electric tissue nicotinic acetylcholine receptor. a negatively charged region of the δ subunit within 0.9 nm of the α subunit binding site disulfide
    • Czajkowski, C. & Karlin, A. (1991). Agonist binding site of Torpedo electric tissue nicotinic acetylcholine receptor. A negatively charged region of the δ subunit within 0.9 nm of the α subunit binding site disulfide. J. Biol. Chem. 266, 22603-22612.
    • (1991) J. Biol. Chem. , vol.266 , pp. 22603-22612
    • Czajkowski, C.1    Karlin, A.2
  • 8
    • 0028852622 scopus 로고
    • Structure of the nicotinic receptor acetylcholine-binding site. Identification of acidic residues in the δ subunit within 0.9 nm of the α subunit binding site disulfide
    • Czajkowski, C. & Karlin, A. (1995). Structure of the nicotinic receptor acetylcholine-binding site. Identification of acidic residues in the δ subunit within 0.9 nm of the α subunit binding site disulfide. J. Biol. Chem. 270, 3160-3164.
    • (1995) J. Biol. Chem. , vol.270 , pp. 3160-3164
    • Czajkowski, C.1    Karlin, A.2
  • 9
    • 0027208097 scopus 로고
    • Negatively charged amino acid residues in the nicotinic δ subunit that contribute to the binding of acetyl-choline
    • Czajkowski, C., Kaufman, C. & Karlin, A. (1993). Negatively charged amino acid residues in the nicotinic δ subunit that contribute to the binding of acetyl-choline. Proc. Natl Acad. Sci. USA, 90, 6285-6289.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 6285-6289
    • Czajkowski, C.1    Kaufman, C.2    Karlin, A.3
  • 10
    • 0024278367 scopus 로고
    • Amino acids of the Torpedo marmorata acetylcholine receptor α subunit labeled by a photoaffinity ligand for the acetylcholine binding site
    • Dennis, M., Giradat, J., Kotzyba-Hibert, F., Goeldner, M., Hirth, C., Chang, J.-Y., Lazure, C., Chrétien, M. & Changeux, J.-P. (1988). Amino acids of the Torpedo marmorata acetylcholine receptor α subunit labeled by a photoaffinity ligand for the acetylcholine binding site. Biochemistry, 27, 2346-2357.
    • (1988) Biochemistry , vol.27 , pp. 2346-2357
    • Dennis, M.1    Giradat, J.2    Kotzyba-Hibert, F.3    Goeldner, M.4    Hirth, C.5    Chang, J.-Y.6    Lazure, C.7    Chrétien, M.8    Changeux, J.-P.9
  • 11
    • 0014945329 scopus 로고
    • Reconstruction of three-dimensional images from electron micrographs of structures with helical symmetry
    • DeRosier, D. & Moore, P. B. (1970). Reconstruction of three-dimensional images from electron micrographs of structures with helical symmetry. J. Mol. Biol. 52, 355-369.
    • (1970) J. Mol. Biol. , vol.52 , pp. 355-369
    • Derosier, D.1    Moore, P.B.2
  • 12
    • 0000865027 scopus 로고
    • Solid-phase peptide synthesis
    • (Neurath, H. & Hill, R. L., eds), 3rd edit., Academic Press, New York
    • Erickson, B. W. & Merrifield, R. B. (1976). Solid-phase peptide synthesis. In The Proteins (Neurath, H. & Hill, R. L., eds), 3rd edit., vol. 2, pp. 255-527, Academic Press, New York.
    • (1976) The Proteins , vol.2 , pp. 255-527
    • Erickson, B.W.1    Merrifield, R.B.2
  • 13
    • 0023053515 scopus 로고
    • Location of terbium binding sites on acetylcholine receptor-enriched membranes
    • Fairclough, R. H., Miake-Lye, R. C., Stroud, R. M., Hodgson, K. O. & Doniach, S. (1986). Location of terbium binding sites on acetylcholine receptor-enriched membranes. J. Mol. Biol. 189, 673-680.
    • (1986) J. Mol. Biol. , vol.189 , pp. 673-680
    • Fairclough, R.H.1    Miake-Lye, R.C.2    Stroud, R.M.3    Hodgson, K.O.4    Doniach, S.5
  • 15
    • 0032544487 scopus 로고    scopus 로고
    • Differential surface accessibility of α(187-199) in the Torpedo acetylcholine receptor α subunits
    • Fairclough, R. H., Twaddle, G. M., Gudipati, E., Lin, M. Y. & Richman, D. P. (1998). Differential surface accessibility of α(187-199) in the Torpedo acetylcholine receptor α subunits. J. Mol. Biol. 282, 317-330.
    • (1998) J. Mol. Biol. , vol.282 , pp. 317-330
    • Fairclough, R.H.1    Twaddle, G.M.2    Gudipati, E.3    Lin, M.Y.4    Richman, D.P.5
  • 16
    • 0017539686 scopus 로고
    • Position sensitive X-ray detector
    • Gabriel, A. (1977). Position sensitive X-ray detector. Rev. Sci. Instrum. 48, 1303-1305.
    • (1977) Rev. Sci. Instrum. , vol.48 , pp. 1303-1305
    • Gabriel, A.1
  • 17
    • 0025346780 scopus 로고
    • Identification of a novel amino acid α-tyrosine 93 within the cholinergic ligand-binding sites of the acetylcholine receptor by photoaffinity labeling
    • Galzi, J.-L., Revah, F., Black, D., Goeldner, M., Hirth, C. & Changeux, J.-P. (1990). Identification of a novel amino acid α-tyrosine 93 within the cholinergic ligand-binding sites of the acetylcholine receptor by photoaffinity labeling. J. Biol. Chem. 265, 10430-10437.
    • (1990) J. Biol. Chem. , vol.265 , pp. 10430-10437
    • Galzi, J.-L.1    Revah, F.2    Black, D.3    Goeldner, M.4    Hirth, C.5    Changeux, J.-P.6
  • 18
    • 0000951677 scopus 로고
    • Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid
    • Geysen, H. M., Meloen, R. H. & Barteling, S. J. (1984). Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid. Proc. Natl Acad. Sci. USA, 81, 3998-4002.
    • (1984) Proc. Natl Acad. Sci. USA , vol.81 , pp. 3998-4002
    • Geysen, H.M.1    Meloen, R.H.2    Barteling, S.J.3
  • 19
    • 0000101418 scopus 로고
    • Anti-acetylcholine receptor antibodies directed against the α-bungarotoxin binding site induce a unique form of experimental myasthenia
    • Gomez, C. M. & Richman, D. P. (1983). Anti-acetylcholine receptor antibodies directed against the α-bungarotoxin binding site induce a unique form of experimental myasthenia. Proc. Natl Acad. Sci. USA, 80, 4089-4093.
    • (1983) Proc. Natl Acad. Sci. USA , vol.80 , pp. 4089-4093
    • Gomez, C.M.1    Richman, D.P.2
  • 20
    • 0039507411 scopus 로고
    • Structure of purple membrane from Halobacterium halobium: Recording, measurement and evaluation of electron micrographs at 3.5 Å resolution
    • Henderson, R., Baldwin, J. M., Downing, K. H., Lepault, J. & Zemlin, E. (1986). Structure of purple membrane from Halobacterium halobium: recording, measurement and evaluation of electron micrographs at 3.5 Å resolution. Ultramicroscopy, 19, 147-178.
    • (1986) Ultramicroscopy , vol.19 , pp. 147-178
    • Henderson, R.1    Baldwin, J.M.2    Downing, K.H.3    Lepault, J.4    Zemlin, E.5
  • 22
    • 0022975251 scopus 로고
    • Acetylcholine receptor binding site contains a disulfide cross-link between adjacent half-cystinyl residues
    • Kao, P. N. & Karlin, A. (1986). Acetylcholine receptor binding site contains a disulfide cross-link between adjacent half-cystinyl residues. J. Biol. Chem. 264, 8085-8088.
    • (1986) J. Biol. Chem. , vol.264 , pp. 8085-8088
    • Kao, P.N.1    Karlin, A.2
  • 23
    • 0021132711 scopus 로고
    • Identification of the α subunit half-cystine specfically labeled by an affinity reagent for the acetylcholine receptor binding site
    • Kao, P. N., Dwork, A. J., Kaldany, R.-R. J., Silver, M. L., Wideman, J., Stein, S. & Karlin, A. (1984). Identification of the α subunit half-cystine specfically labeled by an affinity reagent for the acetylcholine receptor binding site. J. Biol. Chem. 259, 11662-11665.
    • (1984) J. Biol. Chem. , vol.259 , pp. 11662-11665
    • Kao, P.N.1    Dwork, A.J.2    Kaldany, R.-R.J.3    Silver, M.L.4    Wideman, J.5    Stein, S.6    Karlin, A.7
  • 24
    • 0018781849 scopus 로고
    • Immunospecific identification and three-dimensional structure of a membrane-bound acetylcholine receptor from Torpedo californica
    • Klymkowsky, M. W. & Stroud, R. M. (1979). Immunospecific identification and three-dimensional structure of a membrane-bound acetylcholine receptor from Torpedo californica. J. Mol. Biol. 128, 319-334.
    • (1979) J. Mol. Biol. , vol.128 , pp. 319-334
    • Klymkowsky, M.W.1    Stroud, R.M.2
  • 25
    • 0019310282 scopus 로고
    • Protease effects on the structure of acetylcholine receptor membranes from Torpedo californica
    • Klymkowsky, M. W., Heuser, J. E. & Stroud, R. M. (1980). Protease effects on the structure of acetylcholine receptor membranes from Torpedo californica. J. Cell Biol. 85, 823-838.
    • (1980) J. Cell Biol. , vol.85 , pp. 823-838
    • Klymkowsky, M.W.1    Heuser, J.E.2    Stroud, R.M.3
  • 26
    • 0023375835 scopus 로고
    • Location of subunits within the acetylcholine receptor by electron image analysis of tubular crystals from Torpedo marmorata
    • Kubalek, E., Ralston, S., Lindstrom, J. & Unwin, N. (1987). Location of subunits within the acetylcholine receptor by electron image analysis of tubular crystals from Torpedo marmorata. J. Cell Biol. 105, 9-18.
    • (1987) J. Cell Biol. , vol.105 , pp. 9-18
    • Kubalek, E.1    Ralston, S.2    Lindstrom, J.3    Unwin, N.4
  • 27
    • 0014949207 scopus 로고
    • Cleavage of structure proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U. K. (1970). Cleavage of structure proteins during the assembly of the head of bacteriophage T4. Nature, 227, 680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 28
    • 0015229903 scopus 로고
    • Structure of oriented lipid bilayers
    • Levine, Y. K. & Wilkins, M. H. F. (1971). Structure of oriented lipid bilayers. Nature New Biol. 230, 69-72.
    • (1971) Nature New Biol. , vol.230 , pp. 69-72
    • Levine, Y.K.1    Wilkins, M.H.F.2
  • 29
    • 0018178434 scopus 로고
    • A modification of the Lowry procedure to simplify protein determination in membrane and lipo-protein samples
    • Markwell, M. A. K., Hass, S. M., Bieber, L. L. & Tolburt, N. E. (1978). A modification of the Lowry procedure to simplify protein determination in membrane and lipo-protein samples. Anal. Biochem. 87, 206-210.
    • (1978) Anal. Biochem. , vol.87 , pp. 206-210
    • Markwell, M.A.K.1    Hass, S.M.2    Bieber, L.L.3    Tolburt, N.E.4
  • 31
    • 0020729934 scopus 로고
    • Anomalous X-ray scattering from terbium-labeled parvalbumin in solution
    • Miake-Lye, R. C., Doniach, S. & Hodgson, K. O. (1983). Anomalous X-ray scattering from terbium-labeled parvalbumin in solution. Biophys. J. 41, 287-292.
    • (1983) Biophys. J. , vol.41 , pp. 287-292
    • Miake-Lye, R.C.1    Doniach, S.2    Hodgson, K.O.3
  • 32
    • 0025819979 scopus 로고
    • 3H]nicotine as an agonist photoaffinity label
    • 3H]nicotine as an agonist photoaffinity label. Biochemistry, 30, 6987-6997.
    • (1991) Biochemistry , vol.30 , pp. 6987-6997
    • Middleton, R.E.1    Cohen, J.B.2
  • 33
    • 0023180691 scopus 로고
    • Monoclonal antibodies as probes of the α-bungarotoxin and cholinergic binding regions of the acetylcholine receptor
    • Mihovilovic, M. & Richman, D. P. (1987). Monoclonal antibodies as probes of the α-bungarotoxin and cholinergic binding regions of the acetylcholine receptor. J. Biol. Chem. 262, 4978-4986.
    • (1987) J. Biol. Chem. , vol.262 , pp. 4978-4986
    • Mihovilovic, M.1    Richman, D.P.2
  • 34
    • 0030059067 scopus 로고    scopus 로고
    • X-ray diffraction analysis of cytochrome P450 2B4 reconsitituted into liposomes
    • Miller, J. P., Herbette, L. G. & White, R. E. (1996). X-ray diffraction analysis of cytochrome P450 2B4 reconsitituted into liposomes. Biochemistry, 35, 1466-1474.
    • (1996) Biochemistry , vol.35 , pp. 1466-1474
    • Miller, J.P.1    Herbette, L.G.2    White, R.E.3
  • 35
    • 0010526496 scopus 로고
    • Acetylcholine and local anesthetic binding to Torpedo nicotinic postsynaptic membranes after removal of nonreceptor peptides
    • Neubig, R. R., Krodel, E. K., Boyd, N. D. & Cohen, J. B. (1979). Acetylcholine and local anesthetic binding to Torpedo nicotinic postsynaptic membranes after removal of nonreceptor peptides. Proc. Natl Acad. Sci. USA, 76, 690-694.
    • (1979) Proc. Natl Acad. Sci. USA , vol.76 , pp. 690-694
    • Neubig, R.R.1    Krodel, E.K.2    Boyd, N.D.3    Cohen, J.B.4
  • 36
    • 0025308169 scopus 로고
    • d-Tubocurarine binding sites are located at α-γ and α-δ subunit interfaces of the nicotinic acetylcholine receptor
    • Pedersen, S. E. & Cohen, J. B. (1990). d-Tubocurarine binding sites are located at α-γ and α-δ subunit interfaces of the nicotinic acetylcholine receptor. Proc. Natl Acad. Sci. USA, 87, 2785-2789.
    • (1990) Proc. Natl Acad. Sci. USA , vol.87 , pp. 2785-2789
    • Pedersen, S.E.1    Cohen, J.B.2
  • 37
    • 0022972430 scopus 로고
    • Location of ligand-binding sites on the nicotinic acetylcholine receptor α-subunit
    • Pedersen, S. E., Dreyer, E. B. & Cohen, J. B. (1986). Location of ligand-binding sites on the nicotinic acetylcholine receptor α-subunit. J. Biol. Chem. 261, 13735-13743.
    • (1986) J. Biol. Chem. , vol.261 , pp. 13735-13743
    • Pedersen, S.E.1    Dreyer, E.B.2    Cohen, J.B.3
  • 38
    • 0017697580 scopus 로고
    • Structural studies of a membrane-bound acetylcholine receptor from Torpedo californica
    • Ross, M. J., Klymkowsky, M. W., Agard, D. A. & Stroud, R. M. (1977). Structural studies of a membrane-bound acetylcholine receptor from Torpedo californica. J. Mol. Biol. 116, 635-659.
    • (1977) J. Mol. Biol. , vol.116 , pp. 635-659
    • Ross, M.J.1    Klymkowsky, M.W.2    Agard, D.A.3    Stroud, R.M.4
  • 39
    • 0015607082 scopus 로고
    • A simple assay for the study of solubilized acetylcholine receptors
    • Schmidt, J. & Raftery, M. A. (1973). A simple assay for the study of solubilized acetylcholine receptors. Anal. Biochem. 52, 349-354.
    • (1973) Anal. Biochem. , vol.52 , pp. 349-354
    • Schmidt, J.1    Raftery, M.A.2
  • 40
    • 0018341282 scopus 로고
    • Structure determination of asymetric membrane profiles using an iterative Fourier method
    • Stroud, R. M. & Agard, D. A. (1979). Structure determination of asymetric membrane profiles using an iterative Fourier method. Biophys J. 25, 495-512.
    • (1979) Biophys J. , vol.25 , pp. 495-512
    • Stroud, R.M.1    Agard, D.A.2
  • 41
    • 0027506299 scopus 로고
    • Nicotinic acetylcholine receptor at 9 Å resolution
    • Unwin, N. (1993). Nicotinic acetylcholine receptor at 9 Å resolution. J. Mol. Biol. 229, 1101-1124.
    • (1993) J. Mol. Biol. , vol.229 , pp. 1101-1124
    • Unwin, N.1
  • 42
    • 0029984543 scopus 로고    scopus 로고
    • Projection structure of the nicotinic acetylcholine receptor: Distinctconformations of the α subunits
    • Unwin, N. (1996). Projection structure of the nicotinic acetylcholine receptor: distinctconformations of the α subunits. J. Mol. Biol. 257, 586-596.
    • (1996) J. Mol. Biol. , vol.257 , pp. 586-596
    • Unwin, N.1
  • 43
    • 0028268955 scopus 로고
    • Transverse distance between the membrane and the agonist binding sites on the Torpedo acetylcholine receptor: A fluorescence study
    • Valenzuela, C. F., Weign, P., Yguerabide, J. & Johnson, D. A. (1994). Transverse distance between the membrane and the agonist binding sites on the Torpedo acetylcholine receptor: a fluorescence study. Biophys. J. 66, 674-682.
    • (1994) Biophys. J. , vol.66 , pp. 674-682
    • Valenzuela, C.F.1    Weign, P.2    Yguerabide, J.3    Johnson, D.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.