Synthesis and pharmacological evaluation of benzofuran-acetamides as 'antineophobic' mitochondrial DBI receptor complex ligands

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 16, 1998, Pages 2099-2102

  Liao, Yi ^a,d   Kozikowski, Alan P ^b   Guidotti, Alessandro ^b,c   Costa, Erminio ^b  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^d MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ACETAMIDE DERIVATIVE; BENZOFURAN DERIVATIVE; DIAZEPAM BINDING INHIBITOR;

ANIMAL CELL; ARTICLE; CHANNEL GATING; DRUG POTENCY; DRUG RECEPTOR BINDING; LIGAND BINDING; MENTAL DISEASE; NONHUMAN; RAT;

ACETAMIDES; ANIMALS; BENZOFURANS; BINDING, COMPETITIVE; CEREBELLUM; DRUG DESIGN; INDICATORS AND REAGENTS; INDOLEACETIC ACIDS; KINETICS; LIGANDS; MITOCHONDRIA; MOLECULAR STRUCTURE; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0032544136     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00374-6     Document Type: Article

References (18)

1. 1. Villiger, J. W., Neuropharmacology 1985, 24, 95.
2. 2. Jung-Testas, I.; Hu, Z.; Baulieu, E. E. Endocrinol. 1989, 125, 2083.
3. 3. Costa, E.; Guidotti, A. Life Sci. 1991, 49, 325.
4. 4. Mossotti, M.; Slobodyansky, E.; Konkel, D.; Costa, E.; Guidotti, A. Endocrinol. 1991, 129, 591.
5. 5. (a) Spengel, R.; Werner, P.; Seeburg, P. H. J. Biol. Chem. 1989, 264, 20415;
6. (b) McEnery, M. W.; Snowman, A. M.; Trifletti, R. R.; Snyder, S. H. Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 3170.
7. 6. Kozikowski, A. P.; Ma, D.; Brewer, J.; Sun, S.; Costa, E.; Romeo, E.; Guidotti, A. J. Med. Chem. 1993, 36, 2908.
8. 7. Puia, G.; Santi, M. R.; Vicini, S.; Pritchett, D. B.; Seeburg, P. H.; Costa, E. Proc. Natl. Acad. Sci. U.S.A. 1989, 86, 7275.
9. 8. Benavides, J. J.; Guilloux, F.; Allam, D. E.; Uzan, A.; Mizoule, J.; Renault, C.; Dubroeucq, C.; Gueremy, C.; Le Fur, G. Life Sci. 1984, 34, 2613.
10. 9. Romeo, E.; Auta, J.; Kozikowski, A. P.; Ma, D.; Papadopoulos, V.; Puia, G.; Costa, E.; Guidotti, A. J. Pharmacol. Exp. Ther. 1992, 262, 971-978.
11. 10. (a) Casterllino, A. J.; Rapopart, H. J. Org. Chem. 1984, 4399;
12. (b) Mooradian, A.; Dupont, P. E. Tetrahedron Lett. 1967, 2871;
13. (c) Sheradsky T. Tetrahedron Lett. 1966, 5225.
14. 11. Bumgardner, C. L.; Lilly, R. L. Chem. Ind. 1962, 559.
15. 12. Nicoletti, F.; Wroblewski, J. T.; Novelli, A.; Alho, H.; Guidotti, A; Costa, E. J. Neurosci. 1986, 6, 1905.
16. 13. Bylund, D. B.; Yamamura, H. I. In Methods in Neurotransmitter Receptor Analysis; Yamamura, H. L; Enna, S. J.; Kuhar, M. J., Eds.; Raven Press: New York, 1990; pp 1-35.
17. 14. Hughes, J.; Boden, P.; Costall, B.; Domeney, A.; Kelly, E.; Horwell, D. C.; Hunter, J. C.; Pinnock, R. D.; Woodruff, G. N. Proc. Natl. Acad. Sci. U.S.A. 1990, 87, 6728.
18. 2F) C, H, N (within ±0.3% of the theoretical value).