The use of single cell gel electrophoresis and flow cytometry to identify antimutagens from commercial soybean by-products

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 402, Issue 1-2, 1998, Pages 211-218

  Plewa, Michael J ^a,b   Wagner, Elizabeth D ^b   Kirchoff, Lynn ^b   Repetny, Karen ^b   Adams, Lori C ^b   Rayburn, A Lane ^b  

^a 364 Environ/Agric Sci B ^*  (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

2 acetoxyacetylaminofluorene; A nticarcinogenesis; Agriculture; Anticarcinogen; Chemoprotection; Chinese hamster lung cell; Chinese hamster ovary cell; Comet assay; Crops

Indexed keywords

ANTIMUTAGENIC AGENT; N (2 FLUORENYL)ACETAMIDE; SOYBEAN PROTEIN;

ANIMAL CELL; CELL PROTECTION; CHINESE HAMSTER; CHO CELL; CONFERENCE PAPER; FLOW CYTOMETRY; GEL ELECTROPHORESIS; GENOTOXICITY; LUNG ALVEOLUS CELL; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIMUTAGENIC AGENTS; CELL LINE; CRICETINAE; CRICETULUS; ELECTROPHORESIS, AGAR GEL; FLOW CYTOMETRY; MUTATION; SOYBEANS;

EID: 0032543372     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(97)00299-6     Document Type: Conference Paper

References (12)

1. [1] R.A. Weinberg, The action of oncogenes in the cytoplasm and nucleus, Science 230 (1985) 770-776.
2. [2] S. Epstein, Losing the war against cancer: who's to blame and what to do about it, Int. J. Health Serv. 20 (1990) 53-71.
3. [3] T. Beardsley, A war not won, Sci. Am. 270 (1) (1994) 130-138.
4. [4] M.J. Messina, V. Persky, K. Setchell, D.R. Setchell, Soy intake and cancer risk; a review of the in vitro and in vivo data, Nutr. Cancer 21 (1994) 113-131.
5. [5] G. Olwig, Soy Stats: A reference guide, American Soybean Association, 1995, 39 pp.
6. [6] S. De Flora, A. Izzotti, C. Bennicelli, Mechanisms of antimutagenesis and anticarcinogenesis: role in primary prevention, in: G. Bronzetti, H. Hayatsu, S. De Flora, M.D. Waters, D.M. Shankel (Eds.), Antimutagenesis and Anticarcinogenesis Mechanisms III, Plenum, New York, 1993, pp. 1-16.
7. [7] M. Watanabe, A. Matsuoka, N. Yamazaki, M. Hayashi, T. Deguchi, T. Nohmi, T. Sofuni, New sublines of Chinese hamster CHL stably expressing human NAT1 or NAT2 N-acetyltransferases or Salmonella typhimurium O-acetyltransferase: comparison of the sensitivities to nitroarenes and aromatic amines using the in vitro micronucleus test, Cancer Res. 54 (1994) 1672-1677.
8. [8] K.R. Tindall, L.F. Stankowski Jr., Molecular analysis of spontaneous mutations at the gpt locus in Chinese hamster ovary (AS52) cells, Mutation Res. 220 (1989) 241-253.
9. [9] D.W. Fairbairn, P.L. Olive, K.L. O'Neill, The comet assay: a comprehensive review, Mutat. Res. 339 (1995) 37-59.
10. [10] F.J. Otto, H. Oldiges, W. Gohde, V.K. Jain, Flow cytometric measurement of nuclear DNA content variations as a potential in vivo mutagenicity test, Cytometry 2 (1981) 189-191.
11. [11] W.M. Grogan, J.M. Collins, Guide to flow cytometry methods, Marcel Dekker, New York, 1990, 228 pp.
12. [12] D.P. Biradar, A.L. Rayburn, Flow cytogenetic analysis of whole cell clastogenicity of herbicides found in groundwater, Arch. Environ. Contam. Toxicol. 28 (1995) 13-17.