Benzylimidazolines as h5-HT(1B/1D) serotonin receptor ligands: A structure-affinity investigation

Journal of Medicinal Chemistry

Volumn 41, Issue 13, 1998, Pages 2243-2251

  Law, Ho ^a   Dukat, Malgorzata ^a   Teitler, Milt ^b   Lee, David K H ^c   Mazzocco, Lucia ^c   Kamboj, Raj ^c   Rampersad, Vik ^c   Prisinzano, Thomas ^a   Glennon, Richard A ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b ALBANY MEDICAL COLLEGE   (United States)

^c NPS Pharmaceutical Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 TERT BUTYL 2 METHYLBENZYL)IMIDAZOLINE; 2 (4 TERT BUTYLBENZYL) 2 IMIDAZOLINE; ANTIMIGRAINE AGENT; OXYMETAZOLINE; SEROTONIN 1B RECEPTOR; SEROTONIN 1D RECEPTOR; SUMATRIPTAN; UNCLASSIFIED DRUG; ALPHA ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP; DRUG DERIVATIVE; HTR1B PROTEIN, HUMAN; LIGAND; SEROTONIN AGONIST; SEROTONIN RECEPTOR;

ANIMAL TISSUE; ARTICLE; CONFORMATIONAL TRANSITION; DOSE RESPONSE; DRUG RECEPTOR BINDING; DRUG SPECIFICITY; MIGRAINE; NONHUMAN; RABBIT; RECEPTOR AFFINITY; RECEPTOR UPREGULATION; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMISTRY; CHO CELL; DRUG ANTAGONISM; DRUG EFFECT; HAMSTER; HUMAN; IN VITRO STUDY; MALE; METABOLISM; MUSCLE ISOMETRIC CONTRACTION; PHYSIOLOGY; SAPHENOUS VEIN; SYNTHESIS; VASCULAR SMOOTH MUSCLE;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; CHO CELLS; CRICETINAE; CYCLIC AMP; HUMANS; ISOMETRIC CONTRACTION; LIGANDS; MALE; MUSCLE, SMOOTH, VASCULAR; OXYMETAZOLINE; RABBITS; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTOR, SEROTONIN, 5-HT1D; RECEPTORS, ADRENERGIC, ALPHA; RECEPTORS, SEROTONIN; SAPHENOUS VEIN; SEROTONIN AGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032543298     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970513p     Document Type: Article

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