X-ray powder diffraction determination of the relative amount of crystalline acetaminophen in solid dispersions with polyvinylpyrrolidone

International Journal of Pharmaceutics

Volumn 163, Issue 1-2, 1998, Pages 219-224

  De Villiers, Melgardt M ^a,b   Wurster, Dale Eric ^b   Van Der Watt, Jakkie G ^a   Ketkar, Amol ^b  

^a NORTH WEST UNIVERSITY   (South Africa)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Acetaminophen; Crystallinity; Polyvinylpyrrolidone; Solid dispersions; X Ray diffraction

Indexed keywords

PARACETAMOL; POVIDONE;

ANALYTIC METHOD; ARTICLE; CRYSTALLIZATION; DISPERSION; DRUG DETERMINATION; DRUG MIXTURE; FREEZE DRYING; NONHUMAN; PRIORITY JOURNAL; SOLUBILITY; X RAY DIFFRACTION;

EID: 0032542788     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(97)00367-0     Document Type: Article

References (14)

1. Bernabei M.T., Forni F., Coppi G., Iannucelli V., Cameroni R. Crystallinity and equivalence of chloramphenicol palmitate. Farmaco Ed. Pratt. 38:1983;391-402.
2. Black D.B., Lovering E.G. Estimation of the degree of crystallinity in digoxin by X-ray and infrared methods. J. Pharm. Pharmacol. 29:1977;634-687.
3. Chow A.H., Grant D.W. Modification of acetaminophen crystals. Part 3. Influence of initial supersaturation during solution phase growth on crystal properties in the presence and absence of p-acetooxyacetanilide. Int. J. Pharm. 51:1988;123-133.
4. Chow A.H., Grant D.W. Influence of crystallization conditions on the physical properties of acetaminophen crystals: evaluation by multiple linear regression. Int. J. Pharm. 51:1989;115-127.
5. Gubskaya A.V., Lisnyak Y.V., Blagoy Y.P. Effect of grinding on physico-chemical properties of drugs. Part 1. Theophylline: evaluation of particle sizes and degree of crystallinity, relation to dissolution parameters. Drug Dev. Ind. Pharm. 21:1995;1953-1964.
6. Horn D., Dittert W. Chromatographic study of interaction between polyvinylpyrrolidone and drugs. J. Pharm. Sci. 71:1982;1021-1026.
7. Imaizini H., Nambu N., Nagai T. Stability and several physical properties of amorphous and crystalline forms of indomethacin. Chem. Pharm. Bull. 28:1980;2565-2569.
8. Junginger H. Phase transformations as a result of mechanical processing. 3. Communication:phase transformation of sulfanilamide by grinding. Dtsch. Apoth. Ztg. 117:1977;456-459.
9. Lin M.-C., Duncan-Hewitt W.C. Deformation kinetics of acetaminophen crystals. Int. J. Pharm. 106:1994;187-200.
10. Lipman E.C., Summers M.P. The effect of polyvinylpyrrolidone on the dissolution rate of paracetamol. J. Pharm. Pharmacol. 32:1980;21P.
11. Ryan J.A. Compressed pellet X-ray diffraction monitoring for optimization of crystallinity in lyophilized solids: imipenem: cilastitin sodium case. J. Pharm. Sci. 75:1986;805-807.
12. Shefter E., Cheng K.C. Drug-polyvinylpyrrolidone (PVP) dispersion. Differential scanning calorimetry study. Int. J. Pharm. 6:1980;179-182.
13. Suryanarayanan R., Mitchell A.G. Evaluation of two concepts of crystallinity using calcium gluceptate as a model compound. Int. J. Pharm. 24:1985;1-17.
14. Wade, A., Weller, P.J. (Eds.), 1994. Handbook of Pharmaceutical Excipients. American Pharmaceutical Association, Washington, pp. 392-399.