Mechanism of action of vitamin b12. Ultrafast radical clocks provide no evidence for radical intermediates in cyclopropane models for the methylmalonyl-coa to succinyl-coa carbon skeleton rearrangement

Journal of the American Chemical Society

Volumn 120, Issue 6, 1998, Pages 1133-1137

  He, Mu ^a   Dowd, Paul ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 OXOACID COENZYME A TRANSFERASE; CYANOCOBALAMIN; FREE RADICAL; METHYLMALONYL COENZYME A MUTASE; TRANSFER FACTOR;

ARTICLE; CATALYSIS; DISSOCIATION; ELECTRON TRANSPORT; ENZYME ACTIVITY; ENZYME CHEMISTRY; ENZYME MECHANISM; OXIDATION; PROTON TRANSPORT; REACTION ANALYSIS; REDUCTION;

EID: 0032542576     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja971415w     Document Type: Article

References (8)

1. 12. In Handbook of Vitamins, 2nd ed.; Machlin, L. J., Ed.; Marcel Dekker: New York, 1991.
2. Review: Dowd, P. In Selective Hydrocarbon Activation; Davies, J. A., Watson, P. L., Greenberg, A., Liebman, J. F., Eds.; VCH Publishers: Weinheim, 1990; pp 265-301.
3. (a) Wollowitz, S.; Halpern, J. J. Am. Chem. Soc. 1988, 110, 3112-3120.
4. (b) Wollowitz, S.; Halpern, J. J. Am. Chem. Soc. 1984, 106, 8319-8321.
5. (c) Halpern, J. Science 1985, 227, 869-875.
6. (d) Davies, A. G.; Golding, B. T.; Hay-Motherwell, R. S.; Mwesigye-kibende, S.; Rao, D. N. R.; Symons, M. C. R. J. Chem. Soc., Chem. Commun. 1988, 378-380.
7. (e) Zhao, Y.; Such, P.; Retey, J. Angew. Chem., Int. Ed. Engl. 1992, 31, 215-216.
8. (f) Padmakumar, R.; Banerjee, R. J. Biochemistry 1995, 16, 9295-9300.