Spectroscopic investigation of the metal ligation and reactivity of the ferrous active sites of bleomycin and bleomycin derivatives

Journal of the American Chemical Society

Volumn 120, Issue 6, 1998, Pages 1249-1259

  Loeb, Kelly E ^a   Zaleski, Jeffrey M ^a   Hess, Cynthia D ^a   Hecht, Sidney M ^a   Solomon, Edward I ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BLEOMYCIN;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; DNA DEGRADATION; DNA STRAND BREAKAGE; DRUG MECHANISM; DRUG STRUCTURE; LIGAND BINDING; METAL BINDING; OXYGEN AFFINITY; SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 0032542563     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja971839q     Document Type: Article

References (4)

1. Stoddard, B. L.; Howell, P. L.; Ringe, D.; Petsko, G. A. Biochemistry 1990, 29, 8885-8893.
2. Baldwin, J. E.; Bradley, M. Chem. Rev. (Washington, D.C.) 1990, 90, 1079-1088.
3. Que, L., Jr. Iron Carriers and Iron Proteins; Loehr, T. M., Ed.; VCH Publishers: Inc.: New York, 1989; Physical Bioinorganic Chemistry Series, Vol. 5, pp 467-524.
4. Lipscomb, J. D.; Orville, A. M. Metal Ions in Biological Systems; Sigel, H., Sigel, A., Eds.; Marcel Dekker, Inc.: New York, 1992; Vol. 28, pp 243-298.