A new route to cyclen, cyclam and homocyclen

Tetrahedron Letters

Volumn 39, Issue 38, 1998, Pages 6861-6864

  Hervé, Gwénaëlle ^a   Bernard, Hélène ^a   Le Bris, Nathalie ^a   Yaouanc, Jean Jacques ^a   Handel, Henri ^a   Toupet, Loïc ^b  

^a UNIVERSITÉ DE BRETAGNE OCCIDENTALE   (France)

^b UNIVERSITÉ DE RENNES 1   (France)

Author keywords

Bis aminals; Butanedione; Cyclization; Tetraazamacrocycles

Indexed keywords

2,3 BUTANEDIONE; AMINE; CYCLAM; MACROCYCLIC COMPOUND;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CYCLIZATION; STRUCTURE ANALYSIS; SYNTHESIS;

EID: 0032541690     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)01497-X     Document Type: Article

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19. 14. Typical procedure for the deprotection. Ethanol (10 mL) and 10% aqueous hydrochloric acid (20 mL) were added to 1 mmol. of protected macrocycle (4, 5, 6). The mixture was allowed to react two days at 60 °C. Then, solvents were evaporated and the residues were recristallized in EtOH to obtain the well-known macrocycles as tetrahydrochloride with yields > 90%.