Dopamine receptor D4 gene is associated with delusional symptomatology in mood disorders

Psychiatry Research

Volumn 80, Issue 2, 1998, Pages 129-136

  Serretti, Alessandro ^a   Macciardi, Fabio ^a   Cusin, Cristina ^a   Lattuada, Enrico ^a   Lilli, Roberta ^a   Smeraldi, Enrico ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Bipolar disorder; Delusion; DRD4; Symptomatology; Unipolar disorder

Indexed keywords

DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR; DOPAMINE 2 RECEPTOR; DRD4 PROTEIN, HUMAN;

ADULT; ARTICLE; DELUSION; DEPRESSION; DOPAMINERGIC SYSTEM; DOPAMINERGIC TRANSMISSION; FEMALE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MANIC DEPRESSIVE PSYCHOSIS; MENTAL DISEASE; PRIORITY JOURNAL; RECEPTOR GENE; SYMPTOMATOLOGY; ALLELE; BIPOLAR DISORDER; GENETICS; MOOD DISORDER;

ADULT; ALLELES; BIPOLAR DISORDER; DELUSIONS; DEPRESSIVE DISORDER; FEMALE; GENOTYPE; HUMANS; MALE; MOOD DISORDERS; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4;

EID: 0032541194     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1781(98)00056-0     Document Type: Article

References (62)

1. Adamson, M.D., Kennedy, J., Petronis, A., Dean, M., Virkkunen, M., Linnoila, M., Goldman, D., 1995. DRD4 dopamine receptor genotype and CSF monoamine metabolites in Finnish alcoholics and controls. American Journal of Medical Genetics 60, 199-205.
2. American Psychiatric Association, 1994. Diagnostic and Statistical Manual of Mental Disorders, 4th ed. APA, Washington DC, 1994.
3. 4 receptor variants. Journal of Neurochemistry 65, 1157-1165.
4. 4 receptor locus do not contribute to the genetic susceptibility to schizophrenia in a large Swedish kindred. American Journal of Medical Genetics 48, 218-222.
5. Bech, P., Malt, U., Dencker, S., Ahlfors, U., Elgen, K., Lewander, T., Lundell, A., Simpson, G., Lingjaerde, O., 1993. Scales for assessment of diagnosis and severity of mental disorders. Acta Psychiatrica Scandinavica 87, 37-40.
6. 4 dopamine receptor and measures of Novelty Seeking. Nature Genetics 12, 81-84.
7. 4 receptors in schizophrenia. Psychiatry Research 51, 215-230.
8. Cannon, T., Marco, E., 1994. Structural brain abnormalities as indicators of vulnerability to schizophrenia. Schizophrenia Bulletin 20, 89-102.
9. 4 receptor gene in psychotic patients. Biological Psychiatry 34, 459-464.
10. Cichon, S., Nöthen, M.M., Lanezik, M., Rietschel, M., Korner, J., Erdmann, J., Propping, P., 1993. Association study of the repeat polymorphism in exon 3 of the dopamine recpetor gene in schizophrenia. Psychiatric Genetics 3, 162-163.
11. Claridge, G., 1994. Single indicator of risk for schizophrenia: probable fact or likely myth? Schizophrenia Bulletin 20, 151-168.
12. Cloninger, C., 1994. Turning point in the design of linkage studies of schizophrenia. American Journal of Medical Genetics 54, 83-92.
13. Cohen, J., 1988. Statistical Power Analysis for the Behavioral Sciences. Lawrence Erlbaum Associates, Publishers, Hillsdale, New Jersey.
14. Comings, D., 1997. Polygenic inheritance in psychiatric disorders. In: Blum, K., Noble, E. (Eds.), Handbook of Psychiatric Genetics. CRC Press, Boca Raton, Fla., pp. 235-260.
15. Coryell, W., Winokur, G., Shea, T., Maser, J., Endicott, J., Akiskal, H., 1994. The long-term stability of depressive subtypes. American Journal of Psychiatry 151, 199-204.
16. Csernansky, J., Newcomer, J., 1994. Are there neurochemical indicators of risk for schizophrenia? Schizophrenia Bulletin 20, 75-88.
17. 4 receptor gene shows no evidence of association with schizophrenia. American Journal of Medical Genetics 54, 256-258.
18. 4 dopamine receptor genes on chromosome 11. American Journal of Psychiatry 151, 102-106.
19. 4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking. Nature Genetics 12, 78-80.
20. Elliott, J., 1992. Peripheral markers in anxiety and depression. Molecular Aspects of Medicine 13, 173-190.
21. Endicott, J., Spitzer, R., 1978. A diagnostic interview: the Schedule for Affective Disorders and Schizophrenia. Archives of General Psychiatry 35, 837-844.
22. Frankel, W., Schork, N., 1996. Who's afraid of epistasis? Nature Genetics 14, 371-373.
23. Ginsburg, B., Werick, T., Escobar, J., Kugelmass, S., 1996. Molecular genetics of psychopathologies: a search for simple answers to complex problems. Behavior Genetics 26, 325-333.
24. Hamilton, M., 1967. Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology 6, 278-296.
25. Johnson, J., Horwath, E., Weissman, M., 1991. The validity of major depression with psychotic features based on a community study. Archives of General Psychiatry 48, 1075-1081.
26. 4 receptor gene polymorphisms. American Journal of Psychiatry 154, 697-699.
27. 4 receptor (D4DR) exon III seven repeat allele in opioid dependent subjects. Molecular Psychiatry 2, 251-254.
28. Koyama, T., Yamashita, I., 1992. Biological markers of depression: WHO multi-center studies and future perspective. Progress in Neuro-Psychopharmacology and Biological Psychiatry 16, 791-796.
29. Lahiri, D., Nurnberger, J.J., 1991. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acid Research 19, 5444.
30. 4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder. Molecular Psychiatry 1, 121-124.
31. Levinson, D., 1997. Pragmatics and statistics in psychiatric genetics. American Journal of Medical Genetics 74, 220-222.
32. 4 (DRD4) gene. Human Molecular Genetics 2, 767-773.
33. 4 receptor variants and bipolar affective disorder. American Journal of Medical Genetics 54, 259-263.
34. Little, KY., 1988. Amphetamine, but not methylphenidate, predicts antidepressant response. Journal of Clinical Pharmacology 8, 177-183.
35. 4 dopamine receptor gene variant in an Italian schizophrenia kindred. Archives of General Psychiatry 51, 288-293.
36. Macciardi, F., Verga, M., Kennedy, J., Petronis, A., Bersani, G., Pancheri, P., Smeraldi, E., 1994b. An association study between schizophrenia and the dopamine receptor genes DRD3 and DRD4 using haplotype relative risk. Human Heredity 44, 328-336.
37. 4 receptor gene. Psychiatry Research 53, 77-86.
38. 4 receptor and transporter gene polymorphisms and mood disorders. Journal of Affective Disorders 40, 7-13.
39. McGuffin, P., Farmer, A., Harvey, I., 1991. A polydiagnostic application of operational criteria in studies of psychotic illness. Development and reliability of the OPCRIT system. Archives of General Psychiatry 48, 764-770.
40. 4 dopamine receptors in postmortem striatum from patients with schizophrenia. Journal of Neuroscience 15, 2186-2191.
41. 4 receptor gene loci in four Japanese pedigrees. Psychiatry Research 52, 149-157.
42. 4 receptor (D4DR) exon III polymorphism and novelty seeking in Japanese subjects. American Journal of Medical Genetics 74, 501-503.
43. 4 receptor gene and schizophrenia. American Journal of Medical Genetics 60, 452-455.
44. Risch, N., 1990. Linkage strategies for genetically complex traits: I. Multilocus models. American Journal of Medical Genetics 46, 222-228.
45. 4 receptor exon III alleles and variation of novelty seeking in alcoholics. American Journal of Medical Genetics 74, 483-487.
46. 4 receptors elevated in schizophrenia. Nature 365, 441-445.
47. 4 receptor variant, D4GLYCINE194, in Africans, but not in Caucasians: no association with schizophrenia. American Journal of Medical Genetics 54, 384-390.
48. Serretti, A., Macciardi, F., Smeraldi, E., 1996. Identification of symptomatologic patterns common to major psychoses: proposal for a phenotype definition. American Journal of Medical Genetics 67, 393-400.
49. Serretti, A., Macciardi, F., Verga, M., Di Bella, D., Bertelli, S., Nobile, M., Novelli, E., Pedrini, S., Catalano, M. Smeraldi, E., submitted. Association of the DRD4 gene with major psychoses.
50. 4 and psychopathology. Schizophrenia Bulletin, in press.
51. 4 receptor gene and schizophrenia. American Journal of Medical Genetics 54, 8-11.
52. 4 dopamine receptor (DRD4) coding region variants and TH microsatellite in the old order Amish family (OOA110). Psychiatric Genetics 4, 95-99.
53. Siris, S., 1991. Diagnosis of secondary depression in schizophrenia. Implications for DSM-IV. Schizophrenia Bulletin 17, 75-98.
54. 4 receptor variants in unrelated schizophrenic cases and controls. American Journal of Medical Genetics 48, 90-93.
55. 3H]raclopride binding in postmortem caudate nucleus of subjects with schizophrenia or major depression. Brain Research 681, 109-116.
56. Taylor, A.E., Saint-Cyr, J.A., 1990. Depression in Parkinson's disease: reconciling physiological and psychological perspectives. Neuropsychiatric Practical Opinions 2, 92-98.
57. Tsuang, M., Faraone, S., 1990. The Genetics of Mood Disorders. The Johns Hopkins University Press, Baltimore.
58. 4 receptor with high affinity for the antipsychotic clozapine. Nature 350, 610-614.
59. 4 receptor variants in the human population. Nature 358, 149-152.
60. 4 receptor (D4DR) exon III seven repeat alleles in Baltimore longitudinal study of aging participants. Molecular Psychiatry 2, 417-419.
61. Willner, P., 1983. Dopamine and depression: a review of recent evidence. Brain Research Review 6, 211-246.
62. Willner, P., 1995. Dopaminergic mechanisms in depression and mania. In: Bloom, F., Kupfer, D. (Eds.), Psychopharmacology, the Fourth Generation of Progress. Raven Press, New York, pp. 921-931.