Synthesis of 1,19-Aza-1,19-desoxy-avermectin B1a: The First Avermectin Macrolactam

Journal of Organic Chemistry

Volumn 63, Issue 8, 1998, Pages 2591-2596

  Meinke, Peter T ^a   Arison, Byron ^a   Chris Culberson, J ^a   Fisher, Michael H ^a   Mrozik, Helmut ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,19 AZA 1,19 DESOXYAVERMECTIN B; AVERMECTIN DERIVATIVE; UNCLASSIFIED DRUG;

AMINATION; ARTICLE; DRUG CONFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; MOLECULAR INTERACTION;

EID: 0032540465     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo972094+     Document Type: Article

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26. 7 performed in this laboratory indicated that 2,19-bis-epi-AVM was approximately 2 kcal/mol (not 5 kcal/mol) more stable than 19-epi-AVM, a value consistent with that determined for bis-epi macrolactam 12.