Positron emission tomography analysis of [1-11C]acetate kinetics in short-term hibernating myocardium

Circulation

Volumn 97, Issue 10, 1998, Pages 1009-1016

  Schulz, Rainer ^b   Kappeler, Christian ^b   Coenen, Heinz ^b   Bockisch, Andreas ^b   Heusch, Gerd ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b NONE

Author keywords

Hibernation; Ischemia; Metabolism; Myocardial; Tomography

Indexed keywords

ACETIC ACID; ADRENALIN; ASPARTIC ACID; CARBON 11; CARBON DIOXIDE; LACTIC ACID; TRIPHENYLTETRAZOLIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CITRIC ACID CYCLE; CLEARANCE; CONTROLLED STUDY; FEMALE; HEART MUSCLE; HEART MUSCLE BLOOD FLOW; HEART MUSCLE ISCHEMIA; HEART MUSCLE METABOLISM; HEART MUSCLE NECROSIS; HEART MUSCLE OXYGEN CONSUMPTION; HIBERNATION; INOTROPISM; KINETICS; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SWINE;

EID: 0032539915     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.97.10.1009     Document Type: Article

References (53)

1. Brown M, Marshall DR, Sobel BE, Bergmann SR. Delineation of myocardial oxygen utilization with carbon-11-labeled acetate. Circulation. 1987;76:687-696.
2. Brown MA, Myears DW, Bergmann SR. Noninvasive assessment of canine myocardial oxidative metabolism with carbon-11 acetate and positron emission tomography. J Am Coll Cardiol. 1988;12:1054-1063.
3. 11C] acetate and dynamic positron emission tomography. Circulation. 1989;79:134-142.
4. 11C]acetate as a tracer for noninvasive assessment of oxidative metabolism with positron emission tomography in normal, ischemic, postischemic, and hyperemic canine myocardium. Circulation. 1990;81:1594-1605.
5. Buck A, Wolpers G, Hutchins G, Savas V, Mangner T, Nguyen N, Schwaiger M. Effect of carbon-11 acetate recirculation on estimates of myocardial oxygen consumption by PET. J Nucl Med. 1991;32:1950-1957.
6. Buxton DB, Schwaiger M, Nguyen A, Phelps ME, Schelbert HR. Radio-labeled acetate as a tracer of myocardial triarboxylic acid cycle flux. Circ Res. 1988;63:628-634.
7. 11C] acetate and dynamic positron tomography. Circulation. 1989;80:863-872.
8. Ng CK., Huang S-C, Schelbert HR, Buxton DB. Validation of a model for [1-11C]acetate as a tracer of cardiac oxidative metabolism. Am J Physiol. 1994;266:H1304-H1315.
9. Henes CG, Bergmann SR, Walsh MN, Sobel BE, Geltman EM. Assessment of myocardial oxidative metabolic reserve with positron emission tomography and carbon-11 acetate. J Nucl Med. 1989;30:1489-1499.
10. Walsh MN, Geltman EM, Brown MA, Henes CG, Weinheimer CJ, Sobel BE, Bergmann SR. Noninvasive estimation of regional myocardial oxygen consumption by positron emission tomography with carbon-11 acetate in patients with myocardial infarction. J Nucl Med. 1989;30:1798-1808.
11. Gropler RJ, Siegel BA, Sampathkumaran K, Pérez JE, Sobel BE, Bergmann SR, Geltman EM. Dependence of recovery of contractile function of maintenance of oxidative metabolism after myocardial infarction. J Am Coll Cardiol. 1992;19:989-997.
12. Krivokapich J, Huang S-C, Scheiben HR. Assessment of the effects of dobutamine on myocardial blood flow and oxidative metabolism in normal human subjects using nitrogen-13 ammonia and carbon-11 acetate. Am J Cardiol. 1993;71:1351-1356.
13. Kalff V, Hicks RJ, Hutchins G, Topol E, Schwaiger M. Use of carbon-11 acetate and dynamics positron emission tomography to assess regional myocardial oxygen consumption in patients with acute myocardial infarction receiving thrombolysis or coronary angioplasty. Am J Cardiol. 1993;71:529-535.
14. Czernin J, Porenta G, Brunken R, Krivokapich J, Chen K, Bennett R, Hage A, Fung C, Tillisch J, Phelps ME, Schelbert HR. Regional blood flow, oxidative metabolism, and glucose utilization in patients with recent myocardial infarction. Circulation. l993;88:884-895.
15. Vanoverschelde J-J, Wijns W, Depré C, Essamri B, Heyndrickx GR, Borgers M, Bol A, Melin JA. Mechanisms of chronic regional postischemic dysfunction in humans: new insights from the study of noninfarcted collateral-dependent myocardium. Circulation. 1993;87:1513-1523.
16. vom Dahl J, Herman WH, Hicks RJ, Ortiz-Alonso FJ, Lee KS, Allman KC, Wolfe ER Jr, Kalff V, Schwaiger M. Myocardial glucose uptake in patients with insulin-dependent diabetes mellitis assessed quantitatively by dynamic positron emission tomography. Circulation. 1993;88:395-404.
17. Janier MF, Adré-Fouet X, Landais P, Grégoire MC, Lavenne F, Amaya J, Mercier C, Machecourt J, Cinotti L. Perfusion-MVo2 mismatch during inotropic stress in CAD patients with normal contractile function. Am J Physiol. 1996;271::H59-H67.
18. 11C-accucc and positron emission tomography: threshold criteria of reversible dysfunction. Circulation. 1997;95:1417-1424.
19. Randle PJ, England PJ, Denton RM. Control of the tricarboxylate cycle and its interactions with glycolysis during acetate utilization in rat heart. Biochem J. 1970;117:677-695.
20. Russell RR, Taegtmeyer H. Changes in citric acid cycle flux and anaplerosis antedate in functional decline in isolated rat hearts utilizing acctoaceute. J Clin Invest. 1991;87:384-390.
21. Nuutinen EM, Peuhkurinen KJ, Pietiläinen EP, Hiltunen JK, Hassinen IE. Elimination and replenishment of tricarboxylic acid-cycle intermediates in myocardium. Biochem J. 1981;194:867-875.
22. 13C NMR. Magn Reson Med. 1993;30:262-266.
23. 13C NMR studies in perfused rat hearts J Biol Chem. 1983;258:13785-13794.
24. Wiesner RJ, Deussen A, Borst M, Schrader J, Grieshaber MK. Glutamate degradation in the ischemic dog heart: contribution to anaerobic energy production. J Mal Cell Cardiol. 1989;21:49-59.
25. Lewandowski ED. Nuclear magnetic resonance evaluation of metabolic and respiratory support of work load in intact rabbit hearts. Circ Res. 1992;70:576-583.
26. Peuhkurinen KJ, Takala TES, Nuutinen EM, Hassinen LE. Tricarboxylic acid cycle metabolites during ischemia in isolated perfused rat heart. Am J Physiol. 1983;244:H281-H288.
27. Schelbert HR. Positron emission tomography for the assessment of myocardial viability. Circulation. 1991;84(suppl I):I-122-I-131.
28. Bonow RO. The hibernating myocardium: implications for management of congestive heart failure. Am J Cardiol 1995;19:17A-25A.
29. Schulz R, Rose J, Martin C, Brodde OE, Heusch G. Development of short-term myocardial hibernation: its limitation by the severity of ischemia and inotropic stimulation. Circulation. 1993;88:684-695.
30. Heusch G, Rose J, Skyschally A, Post H, Schulz R. Calcium responsiveness in regional myocardial short-term hibernation and stunning in the in situ porcine heart: inotropic responses to postextrasystolic potentiation and intracoronary calcium. Circulation. 1996;93:1556-1566.
31. Theroux P, Ross Jr. J, Franklin D, Kemper WS, Sasayama S. Regional myocardial function in the conscious dog during acute coronary occlusion and responses to morphine, propranolol, nitroglycerin, and lidocaine. Circulation. 1976;53:302-314.
32. Bergmeyer HU, Bernt E, Möllering H, Pfleiderer G. L-Aspartat und L-Asparagin. In: Bergmeyer HU, ed. Methoden der enzymatischen Analyse. Weinheim, Germany: Verlag Chemie; 1970:1651-1655.
33. Bernt E, Bergmeyer HU. L-Glutamat: Bestimmung mit Glutamat-Dehydrogenase und NAD. In: Bergmeyer HU, ed. Methoden der enzymatischen Analyse. Weinheim, Germany: Verlag Chemie; 1970:1659-1663.
34. Pike VW, Eakins MN, Allan RM, Selwyn AP. Preparation of [1-11C] acetate: an agent fur the study of myocardial metabolism by positron emission tomography. Int J Appl Radiat Isot. 1982;33:505-512.
35. Skyschally A, Schulz R, Heusch G. Cordat II: A new program for data acquisition and on-line calculation of hemodynamic and regional myocardial dimension parameters. Comput Biol Med. 1993;23:359-367.
36. Horvath KA, Smith WJ, Laurence RG, Schoen FJ, Appleyard RF, Cohn LH. Recovery and viability of an acute myocardial infarct after transmyocardial laser revascularization. J Am Coll Cardiol. 1995;25:258-263.
37. Austin RE, Aldea GS, Coggins DL, Flynn AE, Hoffman JIE. Profound spatial heterogeneity of coronary reserve: discordance between patterns of resting and maximal myocardial blood flow. Circ Res. 1990;67:319-331.
38. Massie BM, Schwartz GG, Garcia J, Wisneski JA, Weiner MW, Owens T. Myocardial metabolism during increased work states in the porcine left ventricle in vivo. Circ Res. 1994;74:64-73.
39. Zhang J, Duncker DJ, Xu Y, Zhang Y, Path G, Merkle H, Hendrich K, From AHL, Bache RJ, Ugurbil K. Transmural bioenergetic response of normal myocardium to high workstates. Am J Physiol. 1995;268: H1891-H1905.
40. Guth BD, Wisneski JA, Neese RA, White FC, Heusch G, Mazer D, Gertz EW. Myocardial lactatc release during ischemia in swine: relation to regional blood flow. Circulation. 1990;81:1948-1958.
41. Safer B. The metabolic significance of the malate-aspartate cycle in heart. Circ Res. 1975;37:527-533.
42. LaNoue KF, Schoolwerth AC. Metabolite transport in mitochondria. Annu Rev Biochem. 1979;48:871-922.
43. 13C NMR spectra: metabolic flux, regulation, and compartmentation in hearts. Biophys. 1995;69:2090-2102.
44. Mudge GH Jr, Mills RM Jr, Taegtmeyer H, Gorlin R, Lesch M. Alterations of myocardial amino acid metabolism in chronic ischemic heart disease. J Clin Invest. 1976;58:1185-1192.
45. Felig P, Pozefsky T, Cahill ME. Alanine: key role in gluconeogenesis. Science. 1970;167:1003-1004.
46. 3 metabolism in rabbit myocardium. Cardiovasc Res. 1987;60:505-515.
47. Taegtmeyer H, Peterson MB, Ragavan VV, Ferguson AG, Lesch M. De novo alanine synthesis in isolated oxygen-deprived rabbit myocardium. J Biol Chem. 1977;252:5010-5018.
48. 13N)-glutamate in the normal human heart and in patients with coronary artery disease. Eur J Nucl Med. 1982;7:211-215.
49. Gropler RJ, Geltman EM, Sampathkumaran K, Perez JE, Schechtman KB, Conversano A, Sobel BE, Bergmann SR, Siegel BA. Comparison of carbon-11-acetate with fluorine-18-fiuorodeoxyglucose for delineating viable myocardium by positron emission tomography. J Am Coll Cardiol. 1993;22:1587-1597.
50. Rahimtoola SH. Hibernating myocardium has reduced blood flow at rest that increases with low-dose dobutamine. Circulation. 1996;94:3055-3061.
51. Vanoverschelde J-LJ, Wijns W, Borgers M, Heyndrickx GR, Depre C, Flameng W, Melin JA. Chronic myocardial hibernation in humans: from bedside to bench. Circulation. 1997;95:1961-1971.
52. Rahimtoola SH. A perspective on the three large multicenter randomized clinical trials of coronary bypass surgery for chronic stable angina. Circulotion. 1985;72(suppl V):V-123-V-135.
53. Ross J Jr. Myocardial perfusion-contraction matching: implications for coronary heart disease and hibernation. Circulation. 1991;83:1076-1083.