Endothiopeptide inhibitors of HIV-1 protease

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 6, 1998, Pages 699-704

  Yao, Shao ^a   Zutshi, Reena ^a   Chmielewski, Jean ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; PROTEINASE; PROTEINASE INHIBITOR;

ANTIVIRAL ACTIVITY; ARTICLE; COMPETITIVE INHIBITION; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION ANALYSIS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HIV PROTEASE INHIBITORS; HIV-1; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR MIMICRY; OLIGOPEPTIDES; THIOAMIDES;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0032539888     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00100-0     Document Type: Article

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44. 4, and evaporated in vacuo to yield the desired product. Further purification was performed if necessary.
45. 8S 783.4115: (3) δ 9.25 (br, 1H), 7.70 (br, 1H), 7.30-6.90 (m, 14H), 5.40-5.05 (br, 3H), 4.88-4.50 (br, 3H), 3.78 (s, 3H), 2.92 (m, 4H), 2.20 (m, 1H), 1.99 (m, 1H), 1.43 (s, 9H), 1.40 (m, 6H), 0.96 (m, 12H), HRMS obtained 783.4066; (4) δ 8.62 (br, 1H) 7.25-7.06 (m, 11H), 7.01 (br, 1H), 6.85 (br, 1H), 6.79 (br, 1H), 6.67 (br, 1H), 5.19 (br, 1H), 4.93 (br, 1H), 4.79 (br, 1H) 4.66 (br, 1H), 4.51 (m, 1H), 4.28 (m, 1H). 3.73(s, 3H), 3.37 (m, 1H), 3.21 (m, 1H), 3.01 (m, 2H), 2.34 (m, 1H) 2.20 (m, 1H), 1.38 (s, 9H), 1.35-1.25 (m, 6H), 0.97-0.91 (m, 12H), HRMS obtained 783.4122; (5) δ 8.20-7.50 (br, 1H), 7.25-6.90 (m, 14H), 6.63 (br, 1H), 5.33 (m, 1H), 5.00 (m, 1H), 4.60-4.10 (m, 4H), 3.75 (s, 3H), 3.30-2.90 (m, 4H), 2.25-2.00 (m. 2H), 1.40 (s, 9H), 1.35-1.20 (m, 6H), 1.00-0.80 (m, 12H), HRMS obtained 783.4094; (6) δ 9.62 (br, 1H), 7.90 (br, 1H), 7.52 (br, 1H), 7.25 (m, 11H), 6.70 (m, 2H), 5.75 (br, 1H), 5.29 (m, 1H), 4.80 (m, 2H), 4.58 (m, 1H), 4.37 (m, 1H), 3.74 (s, 3H), 3.20-2.85 (m, 4H), 2.35 (m, 1H), 2.20 (m, 1H), 1.46 (s, 9H), 1.30 (m, 6H), 0.95 (m, 12H), HRMS obtained 783.4106; (7) δ 8.50 (br, 1H), 7.25-6.65 (m, 15H) 5.25-4.50 (m-br, 5H), 4.30 (m, 1H), 3.78 (s, 3H), 3.05 (m-br, 2H), 2.81 (m-br, 2H), 2.37 (m-br, 2H), 1.45 (s, 9H), 1.40-1.15 (m, 6H), 1.00 (m, 12H), HRMS obtained 783.4104.
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