Heteroatom-substitution as a strategy for increasing the potency of competitive NMDA antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 4, 1998, Pages 389-394

  Ornstein, Paul L ^a   Arnold, Brian M ^a   Lunn, William H W ^a   Heinz, Lawrence J ^a   Leander, J David ^a   Lodge, David ^a   Schoepp, Darryle D ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (2H TETRAZOL 5 YLMETHYL) 2 PIPERIDINECARBOXYLIC ACID; ANTICONVULSIVE AGENT; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ARTICLE; BRAIN ISCHEMIA; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; HYDROGEN BOND; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; EXCITATORY AMINO ACID ANTAGONISTS; MICE; NEURONS; PIPECOLIC ACIDS; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; SPINAL CORD; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLES;

EID: 0032539509     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00038-9     Document Type: Article

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