Neonatal vitamin K administration and childhood cancer in the north of England: Retrospective case-control study

British Medical Journal

Volumn 316, Issue 7126, 1998, Pages 189-193

  Parker, L ^a   Cole, M ^a   Craft, A W ^a   Hey, E N ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PHYTOMENADIONE; VITAMIN K GROUP;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ARTICLE; CASE CONTROL STUDY; CHILD; CHILDHOOD CANCER; CONTROLLED STUDY; HUMAN; INTRAMUSCULAR DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MEDICAL RECORD; NEWBORN; NORMAL HUMAN; PRIORITY JOURNAL; PROPHYLAXIS; RETROSPECTIVE STUDY; UNITED KINGDOM;

EID: 0032539433     PISSN: 09598146     EISSN: None     Source Type: Journal    
DOI: 10.1136/bmj.316.7126.189     Document Type: Article

References (27)

1. Klebanoff MA, Read JS, Mills JL, Shiono PH. The risk of childhood cancer after neonatal exposure to vitamin K. N Engl J Med 1993;329:905-8.
2. Ekelund H, Finnström O, Gunnarskog J, Källén B, Larsson Y. Administration of vitamin K to newborn infants and childhood cancer. BMJ 1993;307:89-91.
3. Olsen JH, Hetz H, Blinkenberg K, Verder H. Vitamin K regimens and incidence of childhood cancer in Denmark. BMJ 1994;308:895-6.
4. Von Kries R, Göbel U, Hachmeister A, Kaletsch U, Michaelis J. Vitamin K and childhood cancer: a populanon based case-control study in Lower Saxony, Germany. BMJ 1996;313:199-203.
5. Ansell P, Bull D, Roman E. Childhood leukaemia and intramuscular vitamin K: findings from a case-control study. BMJ 1996;313:204-5.
6. Zipursky A. Vitamin K at birth [editorial]. BMJ 1996;313:179-80.
7. Golding J, Paterson M, Kinlen LJ. Factors associated with childhood cancer in a national cohort study. Br J Cancer 1990;62:304-8.
8. Golding J, Greenwood R, Birmingham K, Mott M. Childhood cancer, intramuscular vitamin K, and pethidine given during labour. BMJ 1992;305:241-6.
9. Draper G. The geographical epidemiology of chilhood leukaemia and non-Hodgkin lymphomas in Great Britain 1966-83. London: HMSO, 1991.
10. Craft AW, Ammenidine HA, Scott JES, Wagget J. The Northern Region Children's Malignant Disease Registry 1968-82. Incidence and survival. Br J Cancer 1987;56:853-8.
11. Breslow NE, Day NE. Statistical methods in cancer research. Vol I. The analysis of case-control studies. Lyons: IARC Scientific Publications, 1980:248-79. (Publication No 32.)
12. Breslow NE, Day NE. Statistical methods in cancer research. Vol II. The design and analysis of cohort studies Lyons: IARC Scientific Publications, 1987: 135-7. (Publication No 82.)
13. Greaves MF. Aetiology of acute leukaemia. Lancet 1997;349:344-9.
14. Draper G. Cancer. In: Botting B, ed. The health of our children. OPCS decennial supplement. London: HMSO, 1995:140. (OPCS series DS No 11.)
15. McNinch AW, Upton C, Samuels M, Shearer MJ, McCarthy P, Tripp JH, et al. Plasma concentrations after oral or intramuscular vitamin K1 in neonates. Arch Dis Child 1985;60:814-8.
16. Von Kries R, Hachmeister A, Göbel U. Repeated oral vitamin K prophylaxis in West Germany: acceptance and efficacy. BMJ 1995;310:1097-8.
17. Cornelissen M, von Kries R, Loughnan P, Schubiger G. Prevention of vitamin K deficiency bleeding: efficacy of different multiple oral dose schedules of vitamin K. Eur J Pediatr 1997;156:126-30.
18. Hansen KN, Ebbesen F. Neonatal vitamin K prophylaxis in Denmark: three years' experience with oral administration during the first three months of life compared with one oral administration at birth. Acta Paediatr 1996;85:1137-9.
19. Cornelissen M, Hirasing R. Vitamin K for neonates. BMJ 1994;309: 1441-2.
20. McNinch A. Vitamin K deficiency bleeding. London: Surveillance Unit of the Royal College of Paediatrics and Child Health, 1996.
21. Schubiger G, Tönz O, Grüter J, Shearer MJ. Vitamin K1 concentration in breast-fed neonates after oral or intramuscular administration of a single dose of a new mixed-micellar preparation of phylloquinone. J Pediatr Gastroenterol Nutr 1993;16:135-9.
22. Baenziger O, Kraegger CP, Fanconi S. Oral vitamin K prophylaxis for newborn infants: safe enough? Lancet 1996;348:1456.
23. Laughnan PM, McDougall PN. Does intramuscular vitamin K1 act as an unintended depot preparation ? J Paediatr Child Health 1996;32:251-4.
24. Greer FR, Marshall SP, Foley AL, Suttie JW. Improving the vitamin K status of breastfeeding infants with maternal vitamin K supplements. Pediatrics 1997;99:8-92.
25. Nishiguchi T, Saga K, Sumimoto K, Okada K, Terao T. Vitamin K prophylaxis to prevent neonatal vitamin K deficient intracranial haemorrhage in Shizuoka prefecture. Br J Obstet Gynaecol 1996;103:1078-84.
26. Department of Health and Social Services. Reports on Health and social subjects. No 32. Present day practice in infant feeding: third report. London: HMSO, 1988:35-6.
27. Roman E, Ansell P, Bull D. Leukaemia and non-Hodgkin's lymphoma in children and young adults: are prenatal and neonatal factors important determinants of disease? Br J Cancer 1997;76:406-15.