Crosslinking the EcoRV restriction endonuclease across the DNA-binding site reveals transient intermediates and conformational changes of the enzyme during DNA binding and catalytic turnover

EMBO Journal

Volumn 17, Issue 22, 1998, Pages 6757-6766

  Schulze, Claudia ^a   Jeltsch, Albert ^a   Franke, Ingo ^a   Urbanke, Claus ^b   Pingoud, Alfred ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Protein DNA association; Protein DNA interaction; Restriction endonuclease; Restriction modification system; Specificity

Indexed keywords

BACTERIAL DNA; CIRCULAR DNA; RESTRICTION ENDONUCLEASE;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DNA CLEAVAGE; ENZYME ACTIVE SITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING;

BACTERIA (MICROORGANISMS); NEGIBACTERIA;

EID: 0032538889     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.22.6757     Document Type: Article

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