Synthesis of α,α-disubstituted-α-amino acids by double nucleophilic addition to cyanohydrins

Tetrahedron Letters

Volumn 39, Issue 29, 1998, Pages 5147-5150

  Charette, André B ^a   Gagnon, Alexandre ^a   Janes, Marc ^a   Mellon, Christophe ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BROMIDE; METHYLAMINE; NITRILE;

ALKYLATION; AMINO ACID ANALYSIS; AMINO ACID SEQUENCE; AMINO ACID SYNTHESIS; ARTICLE; CHELATION; OXIDATION; STEREOCHEMISTRY;

EID: 0032537710     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)00983-6     Document Type: Article

References (20)

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14. 3, 5h).
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18. 4 was added followed by the second Grignard reagent. The mixture was warmed to 25 °C and stirred overnight. A standard work-up afforded the crude amine which was purified by flash chromatography.
19. 2, >90%.
20. 4.