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4 and Swern oxidation. 2b / 2c could be prepared from 2a via addition of a Grignard reagent and oxidation or via reaction of a Weinreb derivative of the protected mandelic acid and a Grignard reagent.
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36
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0010381377
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note
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21) Preparation of 5a-e; reaction of 1,3-dichloroacetone with the appropriate sodium alkoxide.
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37
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0010336129
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note
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22) Preparation of 7; treatment of pyruvic aldehyde dimethyl acetal with benzyl alcohol and p-TSA.
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