Synthesis and pharmacological activities of 13-dehydro derivatives of primary prostaglandins

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 12, 1998, Pages 1507-1510

  Tanami, Tohru ^a   Kameo, Kazuya ^a   Ono, Naoya ^a   Nakagawa, Takashi ^b   Annou, Shigesato ^b   Tsuboi, Mie ^b   Tani, Kousuke ^b   Okamoto, Sentaro ^b   Sato, Fumie ^b  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Agonists; Prostaglandins

Indexed keywords

13 DEHYDROPROSTAGLANDIN E1; 13 DEHYDROPROSTAGLANDIN E2; 13 DEHYDROPROSTAGLANDIN E3; 13 DEHYDROPROSTAGLANDIN F1 ALPHA; 13 DEHYDROPROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN DERIVATIVE; PROSTAGLANDIN E1 DERIVATIVE; PROSTAGLANDIN E2 DERIVATIVE; PROSTAGLANDIN F2 ALPHA DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; GUINEA PIG; INTESTINE CONTRACTION; NONHUMAN; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION INHIBITION; TRACHEA MUSCLE;

ANIMALS; GUINEA PIGS; HUMANS; ILEUM; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; MUSCLE CONTRACTION; PLATELET AGGREGATION INHIBITORS; PROSTAGLANDINS;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0032537622     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00247-9     Document Type: Article

References (24)

1. [1] Fried, J.; Lin, C. H. J. Med. Chem. 1973, 6, 429-430.
2. [2] Fried, J.; Sih, J. C. Tetrahedron Lett. 1973, 3899-3902.
3. [3] Jarabak, J.; Braithwaite, S. S. Arch. Biochem. Biophys. 1976, 177, 245-254.
4. [4] Gandolfi, C.; Pellegata, R.; Dradi, E.; Forgione, A.; Pella, E. Il Farmaco, Ed. Sc. 1976, 31, 763-766.
5. [5] Impicciatore, M.; Usardi, M. M.; Bertaccini, G. Pharmacol. Res. Comm. 1976, 8, 187-198.
6. [6] O-Yang, C.; Fried, J.; Tetrahedron Lett. 1983, 24, 2533-2536.
7. [7] Fried, J.; Barton, J. Proc. Natl. Acad Sci. U.S.A. 1977, 74, 2199-2203.
8. [8] Gandolfi, C. A.; Gryglewski, R. J. Pharmacol. Res. Comm. 1978, 10, 885-896.
9. [9] Fried, J.; Mitra, D. K.; Nagarajan, M.; Mehrotra, M. M. J. Med. Chem. 1980, 23, 234-237.
10. [10] Shibasaki, M.; Takahashi, A.; Aoki, T.; Sato, H.; Yamada, S.; Kudo, M.; Kogi, K.; Narita, S. Chem. Pharm. Bull. 1992, 40, 279-281.
11. [11] Skuballa, W.; Vorbrüggen, H. Adv. PG TX LT Res. 1985, 15, 271-273.
12. [12] Skuballa, W.; Schillinger, E.; Stürzebecher, C.-St.; Vorbrüggen, H. J. Med. Chem. 1986, 29, 313-315.
13. [13] Stürzebecher, S.; Haberey, M.; Müller, B.; Schillinger, E.; Schröder, G.; Skuballa, W.; Stock, G.; Vorbrüggen, H.; Witt, W. Prostaglandins 1986, 31, 95-109.
14. [14] Yoshino, T.; Okamoto, S.; Sato, F. J. Org. Chem. 1991, 56, 3205-3207.
15. [15] Knochel, P.; Yeah, M. C. P.; Berk, S. C.; Talbert, J. J. Org. Chem. 1988, 53, 2390-2392.
16. [16] Tujiyama, H.; Ono, N.; Yoshino, T.; Okamoto, S.; Sato, F. Tetrahedron Lett. 1990, 31, 4481-4484.
17. [17] Gandolfi, C.; Doria, G.; Gaio, P. Il Farmaco, Ed. Sc. 1972, 27, 1125-1129.
18. [18] Stork, G.; Isobe, M. J. Am. Chem. Soc. 1975, 97, 4745-4746.
19. [19] Born, G. V. R. Nature 1962, 194, 927-929.
20. [20] Main, I. H. M. Br. J. Pharmac. 1964, 22, 511-519.
21. [21] Franceschini, J.; Mizzotti, B.; Ceserani, R.; Mandelli, V.; Usardi M. M. Pharmacol. Res. Comm. 1977, 9, 899-908.
22. [22] Vane, J. R.; Williams, K. I. Br. J. Pharmac. 1973, 48, 629-639.
23. [23] Ceserani, R.; Marotta, F.; Usardi, M. M.; Orlando, N.; Gandolfi, C.; Bianco, S. Prostaglandins and Medicine 1979, 2, 459-466.
24. [24] Gandolfi, C.; Pellegata, R.; Ceserani, R.; Agresta, G.; Orsini, G.; Usardi, M. M. In Advances in Prostaglandins and Thromboxane Research, Samuelsson, B., Paoletti, R., Ed.; 13-Dehydroprostaglandins. New York: Raven Press, 1976; Vol. 1, pp. 209-214.