Synthesis and in vitro cytotoxicity of lipophilic platinum(II) complexes

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 12, 1998, Pages 1525-1530

  Kokotos, George ^a   Theodorou, Vassiliki ^a   Constantinou Kokotou, Violetta ^b   Gibbons, William A ^b   Roussakis, Christos ^b  

^a UNIVERSITY OF ATHENS   (Greece)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; DICHLORO BIS(2 AMINOHEXADECANOL)PLATINUM; DICHLORO(1,3 HEPATADECANEDIAMINE)PLATINUM; PLATINUM COMPLEX; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PROTON NUCLEAR MAGNETIC RESONANCE;

ANTINEOPLASTIC AGENTS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; ORGANOPLATINUM COMPOUNDS; SPECTROPHOTOMETRY, INFRARED; TUMOR CELLS, CULTURED;

EID: 0032537531     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00256-X     Document Type: Article

References (24)

1. 1. Comess, K. M.; Lippard, S. J. In Molecular Aspects of Anticancer Drug-DNA Interactions; Neidle, S., Waring, M., Eds.; MacMillan: London, 1993; p 134.
2. 2. Pasini, A.; Zunino, F. Angew. Chem. Int. Ed. Engl. 1987, 26, 615.
3. 3. Krakoff, I. H. Cancer Treat. Rep. 1979, 63, 1523.
4. 4. Von Hoff, D. D.; Schilsky, R.; Reichert, C. M.; Reddick, R. L.; Rozencweig, M.; Young, R. C.; Muggia, F. M. Cancer Treat. Rep. 1979, 63, 1527.
5. 5. Eastman, A.; Schulte, N.; Sheibani, N.; Sorenson, C. M. In Platinum and Other Coordination Complexes in Cancer Chemotherapy; Nicolini, M., Ed.; Martinus Nijhoff: Boston, 1988; p 178.
6. 6. Kokotos, G.; Theodorou, V.; Tzougraki, C.; Deforce, D. L. D; Van den Eeckhout, E. G. Bioorg. Med. Chem. Lett. 1997, 7, 2165.
7. 7. Nishizuka, Y. Science 1992, 258, 607.
8. 8. Merrill, A. H. Jr; Nimkar, S.; Menaldino, D.; Hannun, Y. A.; Loomis, C.; Bell, R. M.; Tyagi, S. R.; Lambeth J. D.; Stevens, V. L.; Hunter, R.; Liotta, D. C. Biochemistry 1989, 28, 3138.
9. 9. Kothapalli, R.; Lui, E. M. K.; Guthrie, N.; Chambers, A. F.; Carroll, K. K. Biochem. Pharm. 1994, 47, 1909.
10. 10. Souchard, J.-P.; Cros, T.; Johnson, N. P. J. Med. Chem. 1991, 34, 863.
11. 11. Colombo, A.; Di Gioia, R.; Pasini, A.; Dasdia, T.; Zunino, F. Inorg. Chim. Acta 1986, 125, L1.
12. 12. Kokotos, G.; Martin, V.; Constantinou-Kokotou, V.; Gibbons, W. A. Amino Acids 1996, 11, 329.
13. 13. Gibbons, W. A.; Hughes, R. A.; Charalambous, M.; Christodoulou, M.; Szeto, A.; Aulabaugh, A. E.; Mascani, P.; Toth, I. Liebigs Ann. Chem. 1990, 1175.
14. 14. Kokotos, G.; Constantinou-Kokotou, V.; del Olmo Fernandez, E.; Toth, I.; Gibbons, W. A. Liebigs Ann. Chem. 1992, 961.
15. 2 (366.59): Calc C 72.08, H 11.55, N 7.64 %; Found C 71.91, H 11.51, N 7.32 %.
16. 2O (352.43): Calc C 57.94, H 11.73, N 7.95 %; Found C 57.91, H 11.77, N 7.93 %.
17. 17. The flask has to be kept under aluminium foil. Heating up to 40 °C accelerates the reaction. However, increase of temperature has to be avoided in the case of 2-aminohexadecanol.
18. 2O (540.48): Calc C 35.56, H 7.09, N 5.18 %; Found C 35.82, H 6.70, N 5.08 %.
19. 19. Theodorou, V.; Photaki, I.; Hadjiliadis, N.; Gellert, R. W.; Bau, R. Inorg. Chim. Acta 1982, 60, 1.
20. -1) ∼ 22 (DMF).
21. 21. Theodorou, V.; Hadjiliadis, N. Polyhedron 1985, 4 1283.
22. 22. Mosmann, T. J. Immunol. Methods 1983, 65, 55.
23. 23. Geran, R. J.; Greenbeg, N. H.; McDonald, H. M.; Schumacher, A. M.; Abbot, B. J. Cancer Chemother. Rep. 1972, 3, 1.
24. 24. Roussakis, C.; Gratas, C.; Audouin, A. F.; Le Boterff, J.; Dabouis, G.; Verbist, J. F. Anticancer Research 1991, 11, 2239.