Zinc, thymic endocrine activity and mitogen responsiveness (PHA) in piglets exposed to maternal aflatoxicosis B1 and G1

Veterinary Immunology and Immunopathology

Volumn 62, Issue 3, 1998, Pages 245-260

  Mocchegiani, Eugenio ^a   Corradi, Attilio ^b   Santarelli, Lory ^a   Tibaldi, Alberto ^a   Deangelis, Elena ^b   Borghetti, Paolo ^b   Bonomi, Alberto ^b   Fabris, Nicola ^a   Cabassi, Enrico ^b  

^a Immunology Center   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

Author keywords

Aflatoxins; Mitogen responsiveness; Piglets; Thymulin; Zinc

Indexed keywords

AFLATOXIN B1; AFLATOXIN G1; MITOGENIC AGENT; PHYTOHEMAGGLUTININ; THYMULIN; ZINC;

AFLATOXICOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; FOOD CONTAMINATION; IMMUNOREACTIVITY; IMMUNOTOXICITY; LYMPHOCYTE PROLIFERATION; NEWBORN; NONHUMAN; PRENATAL DRUG EXPOSURE; SWINE; THYMUS; ZINC DEFICIENCY;

AFLATOXIN B1; AFLATOXINS; ANIMALS; BODY WEIGHT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; LYMPHOCYTE ACTIVATION; MALE; MATERNAL-FETAL EXCHANGE; MILK; MYCOTOXICOSIS; ORGAN SIZE; PHYTOHEMAGGLUTININS; PREGNANCY; SWINE; SWINE DISEASES; T-LYMPHOCYTES; THYMIC FACTOR, CIRCULATING; THYMUS GLAND; ZINC;

ANIMALIA; SUS SCROFA;

EID: 0032537077     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-2427(98)00073-7     Document Type: Article

References (33)

1. Bach M.A., Beaurain G. Respective influence of extrinsic and intrinsic factors on age-related decrease of thymic secretion. J. Immunol. 122:1979;1056-1058.
2. Bach J.F., Dardenne M., Pleau J.M., Bach M.A. Isolation, biochemical characteristics and biological activity of a circulating thymic hormone in the mouse and in the human. Ann. N.Y. Acad. Sci. 249:1975;186-193.
3. 1 by mammalian pulmonary tissues. Toxicol. Lett. 75:1995;119-125.
4. Cagne W.E., Dungworth P.L., Moulton J. Pathologic effect of aflatoxin in pigs. J. Pathol. Vet. 5:1968;370-384.
5. Casey C.E. The content of some trace elements in infant milk foods and supplements available in New Zealand. New Zealand Med. J. 85:1977;275-280.
6. Chandra R.K. Trace elements and immune response. Immunol. Today. 4:1983;322-325.
7. Dardenne M., Pleau J.M., Nabama B., Lefancier P., Denien M., Choay J., Bach J.F. Contribution of zinc and other metals to the biological activity of the serum thymic factor. Proc. Natl. Acad. Sci. U.S.A. 79:1982;5370-5373.
8. Dimitri R.A., Gabal M.A. Immunosuppressant activity of aflatoxin ingestion in rabbits measured by response to Mycobacterium bovis antigen: I. Cell mediated immune response measured by skin test reaction. Vet. Hum. Toxicol. 38:1996;333-336.
9. Elshourbagy N.A., Guzelizen P.S. Separation, purification, and characterization of a novel form of hepatic cytochrome P-450 from rats treated with pregnenolone-16 alpha-carbonitrile. J. Biol. Chem. 255:1980;1279-1285.
10. Fabris N., Mocchegiani E. Zinc, human diseases and aging. A review. Aging Clin. Exp. Res. 7:1995;77-93.
11. Fabris N., Mocchegiani E., Amadio L., Zannotti M., Licastro F., Franceschi C. Thymic hormone deficiency in normal aging and Down's syndrome: is there a primary failure of the thymus? Lancet. 1:1984;983-986.
12. Fernandez F.J., Khan H.L. Clinical methods for atomic absorption spectroscopy. Clin. Chem. Newlett. 3:1971;24-28.
13. 1 metabolism in human liver. Proc. Natl. Acad. Sci. U.S.A. 87:1990;8306-8310.
14. Gastinel L.N., Dardenne M., Pleau J.M., Bach J.F. Studies on the zinc binding site to the serum thymic factor. Biochem. Biophys. Acta. 797:1984;147-155.
15. Gregory J.F., Manley D. High performance liquid chromatographic determination of aflatoxins in animal tissues and products. J. Assoc. Off. Anal. Chem. 64:1981;144-151.
16. Griffiths B.B., Rea W.J., Johnson A.R., Ross G.H. Mitogenic effect of mycotoxins on T4 lymphocytes. Microbios. 86:1996;127-134.
17. Harvey R.B., Huff W.E., Kubena L.F., Corrier D.E., Phillips T.D. Progression of aflatoxicosis in growing barrows. Am. J. Vet. Res. 49:1988;482-487.
18. Hill G.M., Miller E.R. Effect of dietary zinc levels on the growth and development of the gilts. J. Anim. Sci. 57:1983;106-113.
19. Keen, C.L., Hurley, L.S., 1989. Zinc and reproduction: effects of deficiency on fetal and postnatal development. In: Mills, C.F. (Ed.), Zinc in Human Biology. Springer-Verlag, London, pp. 183-220.
20. Marin M.L., Murtha J., Dong W., Petska J.J. Effects of mycotoxins on cytokine production and proliferation in EL-4 thymoma cells. J. Toxicol. Environ. Health. 48:1996;379-396.
21. Martin S.J., Mazdai G., Strain J.J., Cotter F., Hanningam B.M. Programmed cell-death (apoptosis) in lymphoid and myeloid cell lines during zinc deficiency. Clin. Exp. Immunol. 8:1991;338-343.
22. ++-mediated endonuclease activation. Science. 242:1988;256-259.
23. McLean M., Dutton M.F. Cellular interactions and metabolism of aflatoxin: an update. Pharmacol. Ther. 65:1995;163-192.
24. Miller D.M., Stuart B.P., Crowell W.A. Experimental aflatoxicosis in swine: morphological and clinical pathological results. Can. J. Comp. Med. 45:1981;343-351.
25. Mills, C.F. (Ed.), 1989. Zinc in Human Biology. Springer-Verlag, London, U.K.
26. 1 on chicken peritoneal macrophages in vitro. Vet. Immunol. Immunopathol. 31:1992;61-76.
27. Panangala V.S., Giambrone J.J., Diener U.L., Davis N.D., Hoerr F.J., Mitra A., Schultz R.D., Wilt G.R. Effects of aflatoxins on the growth performance and immune responses of weanling swine. Am. J. Vet. Res. 47:1986;2062-2067.
28. Prasad A.S. Clinical, endocrinological and biochemical effect of zinc-deficiency. Clin. Endocrinol. Metab. 14:1985;567-589.
29. 1 resistance influences chicken T-cell and thymocyte proliferation. Dev. Comp. Immunol. 15:1991;383-391.
30. 1. Eur. J. Vet. Pathol. 1:1995;117-121.
31. Tizard, I., 1992. Veterinary Immunology, 4th edn. W.B. Saunders, Philadelphia, U.S.A.
32. Wogan, G.N., 1977. Aflatoxins. In: Rodricks, J.V., Hesseltine, C.W., Mehlman, M.A. (Eds.), Mycotoxins in Human and Animal Health. Park Forest South, III. Pathotox, pp. 29-31.
33. Xu, Z.M., Bray, T.M., 1991. Effect of dietary Zn deficiency induced free radical production on the stability of microsomial cytochrome P-450 enzyme system in rats. In: Momcilovic, B. (Ed.), TEMA 7, IMI, Zagreb, (Section 17), pp. 25-26.