Isocyanate-Based Dendritic Building Blocks: Combinatorial Tier Construction and Macromolecular-Property Modification

Angewandte Chemie - International Edition

Volumn 37, Issue 3, 1998, Pages 307-310

  Newkome, George R ^a   Weis, Claus D ^a   Moorefield, Charles N ^a   Baker, Gregory R ^a   Childs, Bradley J ^a   Epperson, Jon ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Combinatorial synthesis; Dendrimers; Isocyanates

Indexed keywords

EID: 0032536396     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-3773(19980216)37:3<307::AID-ANIE307>3.0.CO;2-L     Document Type: Article

References (38)

1. G. R. Newkome, C. N. Moorefield, F. Vögtle, Dendritic Molecules: Concepts, Syntheses, Perspectives, VCH Weinheim, 1996;
2. C. N. Moorefield, G. R. Newkome, Adv. Dendritic Macromol. 1994, 1, 1;
3. J. Issberner, R. Moors, F. Vögtle, Angew. Chem. 1994, 106, 2507;
4. Angew. Chem. Int. Ed. Engl. 1994, 33, 2413;
5. J. M. J. Fréchet, C. J. Hawker, K. L. Wooley, J. Macromol. Sci. Part A 1994, 31, 1627;
6. J. M. J. Fréchet, Science 1994, 263, 1710;
7. D. A. Tomalia, A. M. Naylor, W. A. Goddard, III, Angew. Chem. 1990, 102, 119;
8. Angew. Chem. Int. Ed. Engl. 1990, 29, 138;
9. B. I. Voit, Acta Polymer 1995, 46, 87;
10. N. Ardoin, D. Astruc, Bull. Soc. Chim. Fr. 1996, 132, 875.
11. S. Stevelmans, J. C. M. van Hest, J. F. G. A. Jansen, D. A. F. J. van Boxtel, E. M. M. de Brabander-van den Berg, E. W. Meijer, J. Am. Chem. Soc. 1996, 118, 7398;
12. G. R. Newkome, Z.-q. Yao, G. R. Baker, V. K. Gupta, J. Org. Chem. 1985, 50, 2003.
13. G. R. Newkomc, R. Güther, C. N. Moorefield, F. Cardullo, L. Echegoyen, E. Pérez-Cordero, H. Luftmann, Angew. Chem. 1995, 107, 2159;
14. Angew. Chem. Int. Ed. Engl. 1995, 34, 2023.
15. S. A. Kuzdzal, C, A. Monnig, G. R. Newkome, C. N. Moorefield, J. Chem. Soc. Chem. Commun. 1994, 2139; J. Am. Chem. Soc. 1997, 119, 2255.
16. S. A. Kuzdzal, C, A. Monnig, G. R. Newkome, C. N. Moorefield, J. Chem. Soc. Chem. Commun. 1994, 2139; J. Am. Chem. Soc. 1997, 119, 2255.
17. G. R. Newkome, C N. Moorefield, J. M. Keith, G. R. Baker, G. H. Escamilla, Angew. Chem. 1994, 106, 701; Angew. Client. Int. Ed. Engl. 1994, 33, 666; R. F. Barth, A. H. Soloway, Mol. Chem. Neuropathol. 1994, 21, 139; R. F. Barth, D. M. Adam's, A. H. Soloway, F. Alam, M. V. Darby, Bioconjugate Chem. 1994, 5, 58.
18. G. R. Newkome, C N. Moorefield, J. M. Keith, G. R. Baker, G. H. Escamilla, Angew. Chem. 1994, 106, 701; Angew. Client. Int. Ed. Engl. 1994, 33, 666; R. F. Barth, A. H. Soloway, Mol. Chem. Neuropathol. 1994, 21, 139; R. F. Barth, D. M. Adam's, A. H. Soloway, F. Alam, M. V. Darby, Bioconjugate Chem. 1994, 5, 58.
19. G. R. Newkome, C N. Moorefield, J. M. Keith, G. R. Baker, G. H. Escamilla, Angew. Chem. 1994, 106, 701; Angew. Client. Int. Ed. Engl. 1994, 33, 666; R. F. Barth, A. H. Soloway, Mol. Chem. Neuropathol. 1994, 21, 139; R. F. Barth, D. M. Adam's, A. H. Soloway, F. Alam, M. V. Darby, Bioconjugate Chem. 1994, 5, 58.
20. G. R. Newkome, C N. Moorefield, J. M. Keith, G. R. Baker, G. H. Escamilla, Angew. Chem. 1994, 106, 701; Angew. Client. Int. Ed. Engl. 1994, 33, 666; R. F. Barth, A. H. Soloway, Mol. Chem. Neuropathol. 1994, 21, 139; R. F. Barth, D. M. Adam's, A. H. Soloway, F. Alam, M. V. Darby, Bioconjugate Chem. 1994, 5, 58.
21. R. J. Duan, L. L. Miller, D. A. Tomalia, J. Am. Chem. Soc. 1995. 117, 10783.
22. G. R. Newkome, C. D. Weis, C. N. Moorefield, F. R. Fronczek, Tetrahedron Lett. 1997, 38, 7053: G. R. Newkome, C. D. Weis, U.S. Patent 5 703 271 (December 30, 1997).
23. G. R. Newkome, C. D. Weis, C. N. Moorefield, F. R. Fronczek, Tetrahedron Lett. 1997, 38, 7053: G. R. Newkome, C. D. Weis, U.S. Patent 5 703 271 (December 30, 1997).
24. G. R. Newkome, C. D. Weis, B. J. Childs, Designed Monomers Polym. 1997, in press.
25. X.-D. Xiang, X. Sun, G. Briceño, Y. Lou, K.-A. Wang, H. Chang, W. G. Wallace-Freedman, S.-W. Chen, P. G. Schultz, Science 1995, 265, 1783.
26. T. Carell, E. A. Wintner, A. J. Sutherland, J. Rebek, Jr., Y. M. Dunayevskiy, P. Vouros, Chem. Biol. 1995, 2, 171; L. Bourel, X. Willard, I. Pop, R. Bandelle, D. Horvath, B. Déprey, P. Melnyk, A. Tartar, L'Actual. Chem. 1995(12), 33; M. Cardno, M. Bradley, Tetrahedron Lett. 1996, 37, 135.
27. T. Carell, E. A. Wintner, A. J. Sutherland, J. Rebek, Jr., Y. M. Dunayevskiy, P. Vouros, Chem. Biol. 1995, 2, 171; L. Bourel, X. Willard, I. Pop, R. Bandelle, D. Horvath, B. Déprey, P. Melnyk, A. Tartar, L'Actual. Chem. 1995(12), 33; M. Cardno, M. Bradley, Tetrahedron Lett. 1996, 37, 135.
28. T. Carell, E. A. Wintner, A. J. Sutherland, J. Rebek, Jr., Y. M. Dunayevskiy, P. Vouros, Chem. Biol. 1995, 2, 171; L. Bourel, X. Willard, I. Pop, R. Bandelle, D. Horvath, B. Déprey, P. Melnyk, A. Tartar, L'Actual. Chem. 1995(12), 33; M. Cardno, M. Bradley, Tetrahedron Lett. 1996, 37, 135.
29. M. Goodman, V. Jubian, B. Linton, A. D. Hamilton, J. Am. Chem. Soc. 1995, 117, 11610.
30. R. M. Kim, M. Manna, S. M. Hutchins, P. R. Griffin, N. A. Yates, A. M. Bernick, K. T. Chapman, Proc. Natl. Acad. Sci. USA 1996, 93, 10012.
31. V. Swali, N. J. Wells, G. J. Langley, M. Bradley, J. Org. Chem. 1997, 62, 4902.
32. D. Seebach, R. E. Marti, T. Hintermann, Helv. Chim. Acta 1996, 79, 1710.
33. Commercially available poly(propylene imine) dendrimers were generously provided by DSM. The preparation and characterization was reported: E. M. M. de Brabander-van den Berg, E. W. Meijer, Angew. Chem. 1993, 105, 1370; Angew. Chem. Int. Ed. Engl. 1993, 32, 1308; C. Wörner, R. Mülhaupt, Angew. Chem. 1993, 105, 1367; Angew. Chem. Int. Ed. Engl. 1993, 32, 1306.
34. Commercially available poly(propylene imine) dendrimers were generously provided by DSM. The preparation and characterization was reported: E. M. M. de Brabander-van den Berg, E. W. Meijer, Angew. Chem. 1993, 105, 1370; Angew. Chem. Int. Ed. Engl. 1993, 32, 1308; C. Wörner, R. Mülhaupt, Angew. Chem. 1993, 105, 1367; Angew. Chem. Int. Ed. Engl. 1993, 32, 1306.
35. Commercially available poly(propylene imine) dendrimers were generously provided by DSM. The preparation and characterization was reported: E. M. M. de Brabander-van den Berg, E. W. Meijer, Angew. Chem. 1993, 105, 1370; Angew. Chem. Int. Ed. Engl. 1993, 32, 1308; C. Wörner, R. Mülhaupt, Angew. Chem. 1993, 105, 1367; Angew. Chem. Int. Ed. Engl. 1993, 32, 1306.
36. Commercially available poly(propylene imine) dendrimers were generously provided by DSM. The preparation and characterization was reported: E. M. M. de Brabander-van den Berg, E. W. Meijer, Angew. Chem. 1993, 105, 1370; Angew. Chem. Int. Ed. Engl. 1993, 32, 1308; C. Wörner, R. Mülhaupt, Angew. Chem. 1993, 105, 1367; Angew. Chem. Int. Ed. Engl. 1993, 32, 1306.
37. I. Gitsov, J. M. J. Fréchet, J. Am. Chem. Soc. 1996, 118, 3785; Macromolecules 1993, 26, 6536.
38. I. Gitsov, J. M. J. Fréchet, J. Am. Chem. Soc. 1996, 118, 3785; Macromolecules 1993, 26, 6536.