The effects of strychnine, bicuculline, and ketamine on 'immersion- inhibited' dorsal horn convergent neurons in intact and spinalized rats

Brain Research

Volumn 784, Issue 1-2, 1998, Pages 63-70

  McGaraughty, Steve ^a   Henry, James L ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Bicuculline; Convergent neuron; Dorsal horn; Ketamine; Noxious immersion; Paw; Rat; Strychnine

Indexed keywords

BICUCULLINE; KETAMINE; STRYCHNINE;

AFTERDISCHARGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; MALE; NERVE STIMULATION; NEUROCHEMISTRY; NEUROPATHOLOGY; NEUROPHYSIOLOGY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SPINAL CORD DORSAL HORN; WATER IMMERSION;

ANIMALS; BICUCULLINE; DECEREBRATE STATE; EXCITATORY AMINO ACID ANTAGONISTS; EXTRACELLULAR SPACE; GABA ANTAGONISTS; GLYCINE AGENTS; KETAMINE; MALE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; RECEPTORS, N-METHYL-D-ASPARTATE; STRYCHNINE;

EID: 0032536333     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)01153-0     Document Type: Article

References (39)

1. Albin R.L., Hollongsworth Z., Sakurai S.Y., Gilman S. Inhibitory and excitatory amino acid neurotransmitter binding sites in cynomolgus monkey (Macaca fascicularis) cervical spinal cord. Brain Res. 604:1993;354-357.
2. Basbaum A.I. Distribution of glycine receptor immuno-reactivity in the spinal cord of the rat. J. Comp. Neurol. 278:1988;330-336.
3. Bouhassira D., Gall O., Chitour D., Le Bars D. Dorsal horn convergent neurones: negative feedback triggered by spatial summation of nociceptive afferents. Pain. 62:1995;195-200.
4. Brown A.G., Koerber H.R., Noble R. An intracellular study of spinocervical tract cell responses to natural stimuli and single hair afferent fibres in cats. J. Physiol. 382:1987;354-551.
5. Chung J.M., Kenshalo D.R., Gerhart K.D., Willis W.D. Excitation of primate spinothalamic neurons by cutaneous C-fiber volleys. J. Neurophysiol. 42:1979;1354-1369.
6. Conseiller C., Benoist J.M., Hamann K.F., Mailard M.C., Besson J.M. Effects of ketamine on cell response to cutaneous stimulations in laminae IV and V in the cat's dorsal horn. Eur. J. Pharmacol. 18:1972;346-352.
7. Fitzgerald M. The contralateral input to the dorsal horn of the spinal cord. Brain Res. 236:1982;275-287.
8. Game C.J., Lodge D. The pharmacology of the inhibition of dorsal horn neurones by impulses in myelinated cutaneous afferents in the cat. Exp. Brain Res. 23:1975;75-84.
9. Gerhart K.D., Yezierski R.P., Giesler G.J., Willis W.D. Inhibitory receptive fields of primate spinothalamic tract cells. J. Neurophysiol. 46:1981;1309-1325.
10. Hillman P., Wall P.D. Inhibitory and excitatory factors influencing the receptive fields of lamina 5 spinal cord cells. Exp. Brain Res. 9:1969;284-306.
11. Hongo T., Jankowska E., Lundberg A. Post synaptic excitation and inhibition from primary afferents in neurones of the spinocervical tract. J. Physiol. (Lond.). 199:1968;569-592.
12. King A.E., Lopez-Garcia J.A. Intracellular analysis of cutaneous afferent-induced excitation and inhibition in rat dorsal horn neurones in vitro. J. Neurosci. Meth. 52:1994;61-68.
13. Kitahata L.M., Traub A., Kosaka Y. Lamina-specific suppression of dorsal horn unit activity by ketamine hydrochloride. Anesthesiology. 38:1973;4-11.
14. Le Bars D., Dickenson A.H., Besson J.-M. Diffuse noxious inhibitory controls (DNIC). I. Effects on dorsal horn convergent neurons in the rat Pain. 6:1979;283-304.
15. D. Le Bars, A.H. Dickenson, J.-M. Besson, L. Villanueva, Aspects of sensory processing through convergent neurons, in: T.L. Yaksh (Ed.), Spinal Afferent Processing, Plenum Press, New York, 1986, pp. 467-504.
16. Le Bars D., Villanueva L. Electrophysiological evidence for the activation of descending inhibitory controls by nociceptive afferent pathways. Prog. Brain Res. 77:1988;275-300.
17. A antagonists reduce the inhibition of primate spinothalamic tract neurons produced by stimulation in the periaqueductal gray. Brain Res. 654:1994;286-302.
18. McGaraughty S., Henry J.L. Effects of noxious hindpaw immersion on evoked and spontaneous firing of contralateral convergent dorsal horn neurons in both intact and spinalized rats. Brain Res. Bull. 43:1997;263-267.
19. McGaraughty S., Henry J.L. Relationship between mechano-receptive fields of dorsal horn convergent neurons and the response to noxious immersion of the ipsilateral hindpaw in rats. Pain. 70:1997;133-140.
20. McMahon S.B., Lewin G.R., Wall P.D. Central excitability triggered by noxious inputs. Curr. Opin. Neurobiol. 3:1993;602-610.
21. Mitchell K., Spike R.C., Todd A.J. An immunocytochemical study of glycine receptors and GABA in laminae I-III of rat spinal dorsal horn. J. Neurosci. 13:1993;2371-2381.
22. Nagasaka H., Nagasaka I., Sato I., Matsumoto N., Matsumoto I., Hori T. The effects of ketamine on the excitation and inhibition of dorsal horn WDR neuronal activity induced by bradykinin injection into the femoral artery in cats after spinal cord transection. Anesthesiology. 78:1993;722-732.
23. Ness T.J., Gebhart G.F. Interactions between visceral and cutaneous nociception in the rat. I. Noxious cutaneous stimuli inhibit visceral nociceptive neurons and reflexes J. Neurophysiol. 66:1991;20-28.
24. Okuda T. Comparison of direct and indirect depressant actions of ketamine on dorsal horn cells in rabbits. Neuropharmacology. 25:1986;433-440.
25. Peng Y.B., Lin Q., Willis W.D. Effects of GABA and glycine receptor antagonists on the activity and PAG-induced inhibition of rat dorsal horn neurons. Brain Res. 736:1996;189-201.
26. D.D. Price (Ed.), Psychological and Neural Mechanisms of Pain, Raven Press, New York, 1988.
27. Sandkuhler J., Stelzer B., Fu Q.G. Characteristics of propriospinal modulation of nociceptive lumbar spinal dorsal horn neurons in the cat. Neuroscience. 54:1993;957-967.
28. Sivilotti L., Nistri A. GABA receptor mechanisms in the central nervous systems. Prog. Neurobiol. 36:1991;35-92.
29. Schneider S.P., Perl E.R. Selective excitation of neurones in the mammalian spinal dorsal horn by aspartate and glutamate in vitro: correlation with location and excitatory input. Brain Res. 360:1985;339-343.
30. Schneider S.P., Perl E.R. Comparison of primary afferent and glutamate excitation of neurons in the mammalian spinal dorsal horn. J. Neurosci. 8:1988;2062-2073.
31. Sorkin L.S., McAdoo D.J., Willis W.D. Raphe magnus stimulation-induced antinociception in the cat is associated with release of amino acids as well as serotonin in the lumbar dorsal horn. Brain Res. 618:1993;95-108.
32. Sotgiu M.L., Biella G., Riva L. Poststimulus afterdischarges of spinal WDR and NS units in rats with chronic nerve constriction. Neuroreport. 6:1995;1021-1024.
33. Todd A.J. An electron microscope study of glycine-like immunoreactivity in laminae I-III of the spinal dorsal horn of the rat. Neuroscience. 39:1990;387-394.
34. Tomlinson R.W.W., Gray B.G., Dostrovsky J.O. Inhibition of rat spinal cord dorsal horn neurons by non-segmental noxious cutaneous stimuli. Brain Res. 279:1983;291-294.
35. Traub A. Local, segmental, and supraspinal interaction with a dorsolateral spinal cutaneous afferent system. Exp. Neurol. 10:1964;357-374.
36. Van Den Pol A.N., Gores T. Glycine and glycine receptor immuno-reactivity in brain and spinal cord. J. Neurosci. 8:1988;472-492.
37. W.D. Willis (Ed.), The Pain System, Karger, New York, 1985.
38. W.D. Willis, R.E. Coggeshall (Eds.), Sensory Mechanisms of the Spinal Cord, Plenum Press, New York, 1991.
39. Zarbin M.A., Walmsley J.K., Kuhar M.J. Glycine receptor: light microscopic autoradiographic localization with strychnine. J. Neurosci. 1:1981;532-547.