Mutations in the pore regions of the yeast K+ channel YKC1 affect gating by extracellular K+

EMBO Journal

Volumn 17, Issue 24, 1998, Pages 7190-7198

  Vergani, Paola ^a   Hamilton, David ^a   Jarvis, Simon ^a,b   Blatt, Michael R ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF KENT   (United Kingdom)

Author keywords

Ion permeation; Outward rectifier K+ channel; Potassium dependent gating; Saccharomyces cerevisiae; Site directed mutagenesis

Indexed keywords

CESIUM; POTASSIUM CHANNEL; POTASSIUM ION; RUBIDIUM ION; SODIUM ION;

ARTICLE; HYDROPHILICITY; KINETICS; MUTATION; NONHUMAN; POTASSIUM CELL LEVEL; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

CATIONS, MONOVALENT; ELECTRIC CONDUCTIVITY; ELECTROPHYSIOLOGY; ION CHANNEL GATING; KINETICS; METALS, ALKALI; MODELS, THEORETICAL; MUTAGENESIS, SITE-DIRECTED; POTASSIUM; POTASSIUM CHANNELS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES CEREVISIAE;

EID: 0032535114     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.24.7190     Document Type: Article

References (25)

1. +] - a tale of 2 inactivation mechanisms. Neuron, 15, 951-960.
2. + channel. Science, 271, 653-656.
3. + channel from the plasma membrane of Saccharomyces cerevisiae. J. Membr. Biol., 132, 183-199.
4. Blatt,M.R. (1991) Ion channel gating in plants: physiological implications and integration for stomatal function. J. Membr. Biol., 124, 95-112.
5. + outward rectifier in Vicia guard cells. J. Membr. Biol., 158, 241-256.
6. + channel suggest a subunit basis for ion permeation and gating. Biophys. J., 72, 708-719.
7. + channels. Proc. Natl Acad. Sci. USA, 88, 5092-5095.
8. Creighton,T.E. (1993) Proteins. Vol. 2. Freeman, NY.
9. + conduction and selectivity. Science, 280, 69-77.
10. Gibb,A.J. (1995) Patch-clamp recording. In Ashley,R.H. (ed.), Ion Channels: A Practical Approach. IRL Press at Oxford University Press, Oxford, UK, pp. 1-42.
11. Goldbeter,A. and Koshland,D.E. (1981) An amplified sensitivity arising from covalent modification in biological systems. Proc. Natl Acad. Sci. USA, 78, 6840-6844.
12. Goldstein,S.A.N. (1996) A structural vignette common to voltage sensors and conduction pores - canaliculi. Neuron, 16, 717-722.
13. Groves,J.D. and Tanner,M.J.A. (1992) Glycophorin-A facilitates the expression of human band-3-mediated anion transport in Xenopus oocytes. J. Biol. Chem., 267, 22163-22170.
14. Ketchum,K.A., Joiner,W.J., Sellers,A.J., Kaczmarek,L.K. and Goldstein,S.A.N. (1995) A new family of outwardly rectifying potassium channel proteins with 2 pore domains in tandem. Nature, 376, 690-695.
15. + at the potassium channel selectivity filter. Biophys. J., 74, 1840-1849.
16. Koshland,D.E., Goldbeter,A. and Stock,J.B. (1982) Amplification and adaptation in regulatory and sensory systems. Science, 217, 220-225.
17. + channel with 2 pore domains and novel gating properties. J. Biol. Chem., 271, 4183-1187.
18. + channel during gating. Neuron, 16, 859-867.
19. Lopez-Barneo,J., Hoshi,T., Heinemann,S.H. and Aldrich,R.W. (1993) Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels. Receptors Channels, I, 61-71.
20. + channel Ykcl. EMBO J., 16, 4817-4825.
21. MacKinnon,R. (1995) Pore loops - an emerging theme in ion-channel structure. Neuron, 14, 889-892.
22. Miosga,T., Witzel,A. and Zimmermann,F.K. (1994) Sequence and function analysis of a 9.46 kb fragment of Saccharomyces cerevisiae chromosome X. Yeast, 10, 965-973.
23. + channels. Biophys. J., 69, 2449-2457.
24. + channel. Proc. Natl Acad. Sci. USA, 89, 2466-2470.
25. Press,W., Flannerly,B., Teukolsky,S. and Vetterling,W. (1986) Numerical Recipies: The Art of Scientific Computing. Cambridge University Press, Cambridge, UK.