Synthesis and structure-activity relationships of adenosine analogs as inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase. Modifications at positions 5' and 8

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 24, 1998, Pages 3505-3510

  Aronov, Alex M ^a   Gelb, Michael H ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 N (3 METHYL 2 BUTENYL)ADENOSINE; 6 N BENZYLADENOSINE; 8 (2 THIENYL)ADENOSINE; ADENOSINE DERIVATIVE; ANTIPROTOZOAL AGENT; ENZYME INHIBITOR; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; LEISHMANIA MEXICANA; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ADENOSINE; ANIMALS; ENZYME INHIBITORS; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; LEISHMANIA MEXICANA; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOSOMA;

LEISHMANIA MEXICANA;

EID: 0032534852     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00635-0     Document Type: Article

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17. 17. Qualitative docking of compound 12c was done using Insight II software (Molecular Simulations, Inc., San Diego, CA).