Genomic organization and expression of the human β-synuclein gene (SNCB)

Genomics

Volumn 54, Issue 1, 1998, Pages 173-175

  Lavedan, Christian ^a,b   Leroy, Elisabeth ^a   Torres, Rosarelis ^a   Dehejia, Anindya ^a   Dutra, Amalia ^a   Buchholtz, Stephanie ^a   Nussbaum, Robert L ^a   Polymeropoulos, Mihael H ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b JOHNS HOPKINS BAYVIEW MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOLIPASE;

ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; GENE STRUCTURE; HUMAN; HUMAN CELL; NERVE CELL DEGENERATION; NUCLEOTIDE SEQUENCE; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY; SUBSTANTIA NIGRA;

EID: 0032533677     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1998.5556     Document Type: Article

References (11)

1. Jakes R., Spillantini M. G., Goedert M. Identification of two distinct synucleins from human brain. FEBS Lett. 345:1994;27-32.
2. Jenco J. M., Rawlingson A., Daniels B., Morris A. J. Regulation of phospholipase D2: Selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins. Biochemistry. 37:1998;4901-4909.
3. Kozak M. An analysis of vertebrate mRNA sequences: Intimations of translational control. J. Cell Biol. 115:1991;887-903.
4. Kruger R., Kuhn W., Muller T., Woitalla D., Graeber M., Kosel S., Przuntek H., Epplen J. T., Schols L., Riess O. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat. Genet. 18:1998;106-108.
5. Lavedan C., Leroy E., Dehejia A., Buchholtz S., Dutra A., Nussbaum R. L., Polymeropoulos M. H. Identification, localization and characterization of the human γ-synuclein gene. Hum. Genet. 103:1998;106-112.
6. Maroteaux L., Campanelli J. T., Scheller R. H. Synuclein: A neuron-specific protein localized to the nucleus and presynaptic nerve terminal. J. Neurosci. 8:1988;2804-2815.
7. Nakajo S., Tsukada K., Omata K., Nakamura Y., Nakaya K. A new brain-specific 14-kDa protein is a phosphoprotein. Its complete amino acid sequence and evidence for phosphorylation. Eur. J. Biochem. 217:1993;1057-1063.
8. Parkinson, J. 1817, An Essay on the Shaking Palsy.
9. Polymeropoulos M. H., Lavedan C., Leroy E., Ide S. E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos E. S., Chandrasekharappa S., Athanassiadou A., Papapetropoulos T., Johnson W. G., Lazzarini A. M., Duvoisin R. C., Di Iorio G., Golbe L. I., Nussbaum R. L. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science. 276:1997;2045-2047.
10. Schapira A. H. Nuclear and mitochondrial genetics in Parkinson's disease. J. Med. Genet. 32:1995;411-414.
11. Spillantini M. G., Divane A., Goedert M. Assignment of human alpha-synuclein (SNCA) and beta-synuclein (SNCB) genes to chromosomes 4q21 and 5q35. Genomics. 27:1995;379-381.