A new potent antifungal agent from Actinoplanes sp.

Tetrahedron Letters

Volumn 39, Issue 42, 1998, Pages 7649-7652

  Chu, Min ^a   Truumees, Imbi ^a   Mierzwa, Ronald ^a   Terracciano, Joseph ^a   Patel, Mahesh ^a   Das, Pradip R ^a   Puar, Mohindar S ^a   Chan, Tse Ming ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; SCH 56036; UNCLASSIFIED DRUG; XANTHONE DERIVATIVE;

ANTIFUNGAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG ISOLATION; DRUG STRUCTURE; FERMENTATION; FUNGUS CULTURE; NUCLEAR OVERHAUSER EFFECT; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 0032532801     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)01696-7     Document Type: Article

References (7)

1. 1. Greene, S. I. Treatment of Fungal Infectious in the Human Immunodeficiency Virus - Infected Individual. In Antifungal Drug Therapy, Jacobs, P. H.; Nall, L. editors; Marcel Dekker: New York, 1990, Chapter 23, p 237-246.
2. 2. Chu, M.; Truumees, I.; Mierzwa, R.; Terracciano, J.; Patel, M.; Loebenberg, D.; Kaminski, J.; Das, P.; Puar, M. S. J. Nat. Prod. 1997, 60, 525-528.
3. 3. The producing organism, Actinoplanes sp. SCC2314, was deposited in the collection of the American Type Culture Collection (ATCC) in Rockville, MD, where it has been assigned accession no. ATCC 55600.
4. 4. (a) Onoprienko, V. V.; Koz'min, Y. P.; Kolosov, M. N. Bioorg. Khim. 1978, 4, 1418-1422.
5. (b) Kobayashi, K.; Nishino, C. J. Antibiotics 1988, 41, 502-511.
6. (c) Lee, T. M.; Carter, G. T.; Borders, D. M. J. Chem. Soc. Chem. Commun. 1989, 1771-1773.
7. 5. XAD-16 resin (200 g) was added to the fermentation flask after 24 h due to the observation of a significant decrease of antifungal activity as fermentation process continued. Sch 56036 and related active compounds were possibly decomposed in the aqueous culture media.