Precursors of the purine backbone augment the inhibitory action of hypoxanthine and dibutyryl cAMP on mouse oocyte maturation

Journal of Experimental Zoology

Volumn 282, Issue 3, 1998, Pages 376-384

  Downs, Stephen M ^a  

^a MARQUETTE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0032531755     PISSN: 0022104X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-010X(19981015)282:3<376::AID-JEZ10>3.0.CO;2-D     Document Type: Article

References (17)

1. Boss, G.R. (1984) Decreased phosphoribosylpyrophosphate as the basis for decreased purine synthesis during amino acid starvation of human lymphoblasts. J. Biol. Chem., 259:2936-2941.
2. Downs, S.M. (1993) Purine control of mouse oocyte maturation: Evidence that nonmetabolized hypoxanthine maintains meiotic arrest. Mol. Reprod. Dev., 35:82-94.
3. Downs, S.M. (1995a) The influence of glucose, cumulus cells, and metabolic coupling on ATP levels and meiotic control in the isolated mouse oocyte. Dev. Biol., 167:502-512.
4. Downs, S.M. (1995b) Ovulation 2: Control of the resumption of meiotic maturation in mammalian oocytes. In: Gametes - The Oocyte. J.G. Grudzinskas and J.L. Yovich, eds. Cambridge University Press, Cambridge, pp. 150-192.
5. Downs, S.M, D.L. Coleman, P.F. Ward-Bailey, and J.J. Eppig (1985) Hypoxanthine is the principal inhibitor of murine oocyte maturation in a low molecular weight fraction of porcine follicular fluid. PNAS, 82:454-458.
6. Downs, S.M., D.L. Coleman, and J.J. Eppig (1986) Maintenance of murine oocyte meiotic arrest: uptake and metabolism of hypoxanthine and adenosine by cumulus cell-enclosed and denuded oocytes. Dev. Biol., 117:174-183.
7. Downs, S.M., S.A.J. Daniel, E.A. Bornslaeger, P.C. Hoppe, and J.J. Eppig (1989) Maintenance of meiotic arrest in mouse oocytes by purines: modulation of cAMP levels and cAMP phosphodiesterase activity. Gamete Res., 23:323-334.
8. Downs, S.M., and J.J. Eppig (1984) Cyclic adenosine monophosphate and ovarian follicular fluid act synergistically to inhibit mouse oocyte maturation. Endocrinology, 114:418-427.
9. Downs, S.M., and J.J. Eppig (1987) Induction of mouse oocyte maturation in vivo by perturbants of purine metabolism. Biol. Reprod., 36:431-437.
10. Downs, S.M., P.G. Humpherson, and H.J. Leese (1998) Meiotic induction in cumulus cell-enclosed oocytes: involvement of the pentose phosphate pathway. Biol. Reprod., 58:1084-1094.
11. Downs, S.M., and A.M. Mastropolo (1994) The participation of energy substrates in the control of meiotic maturation in murine oocytes. Dev. Biol., 162:154-168.
12. Downs, S.M., and A.M. Mastropolo (1997) Culture conditions affect meiotic regulation in cumulus cell-enclosed mouse oocytes. Mol. Reprod. Dev., 46:551-566.
13. Eppig, J.J. (1991) Maintenance of meiotic arrest and the induction of oocyte maturation in mouse oocyte-granulosa cell complexes developed in vitro from preantral follicles. Biol. Reprod., 45:824-830.
14. Eppig, J.J., P.F. Ward-Bailey, and D.L. Coleman (1985) Hypoxanthine and adenosine in murine ovarian follicular fluid: Concentrations and activity in maintaining oocyte meiotic arrest. Biol. Reprod., 33:1041-1049.
15. Fagbohun, C.F., and S.M. Downs (1992) Requirement for glucose in ligand-stimulated meiotic maturation of cumulus cell-enclosed mouse oocytes. J. Reprod. Fert., 96:681-697.
16. Pincus, G., and E.V. Enzmann (1935) The comparative behavior of mammalian eggs in vitro and in vivo. J. Exp. Med., 62:665-675.
17. Tsafriri, A. and N. Dekel (1994) Molecular mechanisms in ovulation. In: Molecular Biology of the Female Reproductive System. J.K. Findlay, ed. Academic Press, San Diego, pp. 207-258.