Rationale for the combination of anti-aggregating drugs

Thrombosis Research

Volumn 92, Issue 1 SUPPL. 1, 1998, Pages

  Herman, A G ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Aggregation pathway; Anti aggregating drugs; Drug combination; Glycoprotein IIb IIIa receptor

Indexed keywords

1,10 PHENANTHROLINE; ABCIXIMAB; ACETYLSALICYLIC ACID; ADRENALIN; ANTICOAGULANT AGENT; APYRASE; ARACHIDONIC ACID; ARGATROBAN; CALCIUM; CLOPIDOGREL; CYCLIC AMP PHOSPHODIESTERASE; CYCLIC GMP PHOSPHODIESTERASE; DISINTEGRIN; FIBRINOGEN; FIBRINOGEN RECEPTOR; FIBRINOGEN RECEPTOR ANTAGONIST; HEPARIN; HIRUDIN; KETANSERIN; LAMIFIBAN; PROSTAGLANDIN SYNTHASE INHIBITOR; SEROTONIN; THROMBOXANE A2; THROMBOXANE SYNTHASE INHIBITOR; TICLOPIDINE; TIROFIBAN; XEMILOFIBAN;

CALCIUM CELL LEVEL; CONFERENCE PAPER; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE RELEASE REACTION;

ARACHIDONIC ACID; BLOOD PLATELETS; CYCLIC AMP; CYCLIC GMP; DRUG COMBINATIONS; HUMANS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; THROMBOXANE A2;

EID: 0032531117     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(98)00100-5     Document Type: Conference Paper

References (11)

1. Sawicki G., Salas E., Murat J., Miszta-Lane H., Radomski M.W. Release of gelatinase A during platelet activation mediates aggregation. Nature. 386:1997;616-619.
2. Baumgartner H.G., Born G.V.R. Effect of 5-hydroxytryptamine on platelet aggregation. Nature. 218:1960;137-141.
3. Schror K. The basic pharmacology of ticlopidine and clopidogrel. Platelet. 4:1993;252-261.
4. 2 in ischaemic heart disease. Blood Coagul Fibrinolysis. 1:1990;201-210.
5. Rao G.H., Johnson G.J., White J.G. Influence of epinephrine on the aggregation response of aspirin-treated platelets. Prostaglandins Med. 5:1980;45-58.
6. Coller B.S. Platelets and thrombolytic therapy. N Engl J Med. 322:1990;33-42.
7. Matsumoto Y, Marukawa K, Okumura H., Nakazawa T, Yoshikawa T, Tani T, Kimura Y. Comparative study of anti-platelet drugs in vitro: Distinct effect of cAMP-elevating drugs and GP IIb/IIIa blocker on thrombin-induced platelet activation. Thromb Haemost 1997;664(Suppl).
8. Radomski M., Palmer R.M.J., Moncada S. The anti-aggregating properties of vascular endothelium. Interaction between prostacyclin and nitric oxide Br J Pharmacol. 91:1987;639-646.
9. Bult H., Fret H.R.L., Jordaens F., Herman A.G. Dipyridamole potentiates platelet inhibition by nitric oxide. Thromb Haemost. 66:1991;343-349.
10. Lefkovits J., Plow E., Topol E. Platelet glycoprotein IIb/IIIa receptors in cardiovascular medicine. N Engl J Med. 332:1995;1553-1559.
11. Gresele P., Deckmyn H., Nenci G.G., Vermylen J. Thromboxane synthase inhibitors, thromboxane receptors antagonists and dual blockers in thrombotic disorders. Trends Pharmacol Sci. 12:1991;160-163.